RSS-Feed abonnieren
DOI: 10.1055/a-2006-4248
Efficacy of Work-Related Support Rehabilitation for Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials
Wirksamkeit der berufsbezogenen unterstützenden Rehabilitation bei Krebspatienten: Eine Metaanalyse von randomisierten kontrollierten Studien![](https://www.thieme-connect.de/media/physmed/202402/lookinside/thumbnails/2022-01-0593_10-1055-a-2006-4248-1.jpg)
Abstract
Introduction The efficacy of work-related support rehabilitation for patients with cancer remains controversial. We conduct a systematic review and meta-analysis to explore the influence of work-related support rehabilitation on the quality of life in patients with cancer.
Methods We have searched Pubmed, Embase, Web of science, Ebsco, and Cochrane library databases through August 2021 for randomized controlled trials (RCTs) assessing the effect of work-related support rehabilitation on the quality of life in patients with cancer. This meta-analysis is performed using the random-effect model.
Results Four RCTs are included in the meta-analysis. Overall, compared with usual care for cancer patients, work-related support is associated with significantly improved quality of life physical score (PCS, standard mean difference [SMD]=0.22; 95% confidence interval [CI]=0.06 to 0.37; P=0.005) and reduced quality of life pain (SMD=−0.16; 95% CI=−0.31 to 0; P=0.04), but showed no obvious impact on quality of life mental score (MCS, SMD=0; 95% CI=−0.28 to 0.28; P=0.98), time of return to work (SMD=−0.78; 95% CI=−2.71 to 1.14; P=0.43), or the scores of work ability (SMD=−0.01; 95% CI=−0.16 to 9.09; P=0.13) and work limitation (SMD=0.12; 95% CI=−0.16 to 0.40; P=0.41).
Conclusions Work-related support rehabilitation may be effective to improve the quality of life of cancer patients.
Zusammenfassung
Hintergrund und Ziel Die Wirksamkeit der berufsbezogenen unterstützenden Rehabilitation für Krebspatienten ist nach wie vor umstritten. Wir erstellten einen systematischen Review mit Metaanalyse, um den Einfluss der berufsbezogenen unterstützenden Rehabilitation auf die Lebensqualität von Krebspatienten zu untersuchen.
Methodik Wir führten eine Suche in den Datenbanken Pubmed, Embase, Web of Science, Ebsco und Cochrane Library nach bis August 2021 erschienenen randomisierten kontrollierten Studien (RCTs) durch, die sich mit der Wirkung der berufsbezogenen unterstützenden Rehabilitation auf die Lebensqualität von Krebspatienten befassen. Die Metaanalyse erfolgte unter Nutzung eines Random Effects-Modells.
Ergebnisse Vier RCTs wurden in die Metaanalyse einbezogen. Insgesamt ging die berufsbezogene Unterstützung von Krebspatienten im Vergleich zur Regelversorgung mit deutlich besseren PCS-Scores [physische Lebensqualität] (standardisierte Mittelwertdifferenz [SMD]=0,22; 95-%-KI, 0,06–0,37; P=0,005) und verminderten Lebensqualität-Schmerz-Scores (SMD=−0,16; 95-%-KI, −0.31–0; P=0,04) einher, zeigte aber keinen klar erkennbaren Einfluss auf die MCS-Scores (psychische Lebensqualität] (SMD=0; 95-%-KI, −0,28–0,28; P=0,98), den Zeitpunkt der Rückkehr an den Arbeitsplatz (SMD=−0,78; 95-%-KI, −2,71–1,14; P=0,43) oder die Arbeitsfähigkeits-Scores (SMD=−0,01; 95-%-KI, −0,16–9,09; P=0,13) und die Arbeitseinschränkung (SMD=0,12; 95-%-KI, −0,16–0,40; P=0,41).
Schlussfolgerung Die berufsbezogene unterstützende Rehabilitation ist möglicherweise eine wirksame Maßnahme zur Verbesserung der Lebensqualität von Krebspatienten.
Key words
cancer - quality of life - work-related support rehabilitation - randomized controlled trials - meta-analysisPublikationsverlauf
Eingereicht: 05. Januar 2022
Angenommen: 03. Januar 2023
Artikel online veröffentlicht:
09. Februar 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Seifart U, Schmielau J. Return to Work of Cancer Survivors. Oncology research and treatment 40 2017; 760-763
- 2 Islam T, Dahlui M, Majid HA.. et al. Factors associated with return to work of breast cancer survivors: a systematic review. BMC public health 14 Suppl 3(Suppl 3) 2014; S8
- 3 de Boer AG, Taskila TK, Tamminga SJ.. et al. Interventions to enhance return-to-work for cancer patients. The Cochrane database of systematic reviews 2015 9 2015; Cd007569
- 4 Berger AM, Mooney K, Alvarez-Perez A.. et al. Cancer-Related Fatigue, Version 2.2015. Journal of the National Comprehensive Cancer Network : JNCCN 13 2015; 1012-1039
- 5 Weis J.. Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert review of pharmacoeconomics & outcomes research 11 2011; 441-446
- 6 Duijts SF, van Egmond MP, Spelten E.. et al. Physical and psychosocial problems in cancer survivors beyond return to work: a systematic review. Psycho-oncology 23 2014; 481-492
- 7 Wells M, Williams B, Firnigl D.. et al. Supporting 'work-related goals' rather than 'return to work' after cancer? A systematic review and meta-synthesis of 25 qualitative studies. Psycho-oncology 22 2013; 1208-1219
- 8 Rasmussen DM, Elverdam B.. The meaning of work and working life after cancer: an interview study. Psycho-oncology 17 2008; 1232-1238
- 9 Duijts SFA, van Egmond MP, Gits M.. et al. Cancer survivors' perspectives and experiences regarding behavioral determinants of return to work and continuation of work. Disability and rehabilitation 39 2017; 2164-2172
- 10 Kale HP, Carroll NV.. Self-reported financial burden of cancer care and its effect on physical and mental health-related quality of life among US cancer survivors. Cancer 122 2016; 283-289
- 11 de Boer AG, Bruinvels DJ, Tytgat KM.. et al. Employment status and work-related problems of gastrointestinal cancer patients at diagnosis: a cross-sectional study. BMJ open 1 2011; e000190
- 12 Zaman AG, Tytgat KM, Klinkenbijl JH.. et al. Design of a multicentre randomized controlled trial to evaluate the effectiveness of a tailored clinical support intervention to enhance return to work for gastrointestinal cancer patients. BMC cancer 16 2016; 303
- 13 Leensen MCJ, Groeneveld IF, Rejda T.. et al. Feasibility of a multidisciplinary intervention to help cancer patients return to work. European journal of cancer care 27 2018; e12690
- 14 Stapelfeldt CM, Labriola M, Jensen AB.. et al. Municipal return to work management in cancer survivors undergoing cancer treatment: a protocol on a controlled intervention study. BMC public health 15 2015; 720
- 15 Zaman A, Tytgat K, Klinkenbijl JHG.. et al. Effectiveness of a Tailored Work-Related Support Intervention for Patients Diagnosed with Gastrointestinal Cancer: A Multicenter Randomized Controlled Trial. Journal of occupational rehabilitation 31 2021; 323-338
- 16 Tamminga SJ, Verbeek J, Bos M.. et al. Two-Year Follow-Up of a Multi-centre Randomized Controlled Trial to Study Effectiveness of a Hospital-Based Work Support Intervention for Cancer Patients. Journal of occupational rehabilitation 29 2019; 701-710
- 17 Grunfeld EA, Schumacher L, Armaou M.. et al. Feasibility randomised controlled trial of a guided workbook intervention to support work-related goals among cancer survivors in the UK. BMJ open 9 2019; e022746
- 18 Moher D, Liberati A, Tetzlaff J.. et al. Group Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Journal of clinical epidemiology 62 2009; 1006-1012
- 19 He B, Zhao J-Q, Zhang M-Z.. et al. Zoledronic acid and fracture risk: a meta-analysis of 12 randomized controlled trials. Eur Rev Med Pharmacol Sci 25 2021; 1564-1573
- 20 Jadad AR, Moore RA, Carroll D.. et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clinical Trials 17 1996; 1-12
- 21 Kjaergard LL, Villumsen J, Gluud C.. Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses. Annals of Internal Medicine 135 2001; 982-989
- 22 Higgins JP, Thompson SG.. Quantifying heterogeneity in a meta-analysis. Statistics in medicine 21 2002; 1539-1558
- 23 Fauser D, Wienert J, Zomorodbakhsch B.. et al. Work-Related Medical Rehabilitation in Cancer: A Cluster-Randomized Multicenter Study. Deutsches Arzteblatt international 116(35-36) 2019; 592-599
- 24 Kolator M, Kolator P, Zatoński T.. Assessment of quality of life in patients with laryngeal cancer: A review of articles. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 27 2018; 711-715
- 25 Hamer J, McDonald R, Zhang L.. et al. Quality of life (QOL) and symptom burden (SB) in patients with breast cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 25 2017; 409-419
- 26 Chou YJ, Kuo HJ, Shun SC.. Cancer Prehabilitation Programs and Their Effects on Quality of Life. Oncology nursing forum 45 2018; 726-736
- 27 Abdulah DM, Abdulla BMO.. Effectiveness of group art therapy on quality of life in paediatric patients with cancer: A randomized controlled trial. Complementary therapies in medicine 41 2018; 180-185
- 28 Aass N, Fosså SD, Dahl AA.. et al. Prevalence of anxiety and depression in cancer patients seen at the Norwegian Radium Hospital, European journal of cancer. Oxford, England : 1990 33 1997; 1597-1604
- 29 Cascella M, Di Napoli R, Carbone D.. et al. Chemotherapy-related cognitive impairment: mechanisms, clinical features and research perspectives. Recenti progressi in medicina 109 2018; 523-530
- 30 Schmidt ME, Scherer S, Wiskemann J.. et al. Return to work after breast cancer: The role of treatment-related side effects and potential impact on quality of life. European journal of cancer care 28 2019; e13051
- 31 Davis JA, Robinson RL, Le TK.. et al. Incidence and impact of pain conditions and comorbid illnesses. Journal of pain research 4 2011; 331-345
- 32 Lewandowska A, Rudzki G, Lewandowski T.. et al. Quality of Life of Cancer Patients Treated with Chemotherapy. International journal of environmental research and public health. 17. 2020