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Synthesis 2023; 55(09): 1451-1459
DOI: 10.1055/a-1988-5764
DOI: 10.1055/a-1988-5764
paper
Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N-Heteroarenes with Sodium Hydride as the Reductant
This work was supported by the National Natural Science Foundation of China (22271206 and 22071053), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), East China University of Science and Technology, the ‘111’ Project and PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).
Abstract
An efficient and convenient palladium-catalyzed reductive system by employing sodium hydride as the hydrogen donor and acetic anhydride as an activator has been developed for transfer hydrogenation and acetylation of a wide range of N-heteroarenes including quinoline, phthalazine, quinoxaline, phenazine, phenanthridine, and indole. Moreover, acridine substrates could be directly reduced without the use of acetic anhydride. This protocol provides a simple method for the preparation of various saturated N-heterocycles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1988-5764.
- Supporting Information
Publication History
Received: 06 September 2022
Accepted after revision: 28 November 2022
Accepted Manuscript online:
28 November 2022
Article published online:
03 January 2023
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