a
Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, Shenzhen 518055, P. R. of China
b
Shenzhen Bay Laboratory, Shenzhen 518132, P. R. of China
› InstitutsangabenThis research was funded by NSFC (21971104 and 22271136), Education Department of Guangdong Province, Key research projects in colleges and universities in Guangdong Province (2021ZDZX2035), Shenzhen Bay Laboratory (SZBL2019062801006), Guangdong Provincial Key Laboratory of Catalysis (2020B121201002), Shenzhen Nobel Prize Scientists Laboratory Project (C17783101), Guangdong Innovative Program (2019BT02Y335), Innovative Team of Universities in Guangdong Province (2020KCXTD016) and Shenzhen Science and Technology Innovation Committee (ZDSYS20190902093215877, JCYJ20190809140611364).
In this account, we wish to share some stories behind our 13-step synthesis of the caged complex diterpenoid atropurpuran. Although our approach might appear to have proceeded smoothly, the unraveling of the core-construction puzzle and late-stage decorations was full of drama.
The step count here is based on the literature definition [A reaction step is defined as one in which a substrate is converted into a product in a single reaction flask (irrespective of the number of transformations) without intermediate workup or purification], see:
15a
Kawamura S,
Chu H,
Felding J,
Baran PS.
Nature 2016; 532: 90
