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Exp Clin Endocrinol Diabetes 2022; 130(12): 814-820
DOI: 10.1055/a-1936-3310
Article

Effects of High-Fructose Corn Syrup Intake on Glucocorticoid Metabolism in Rats During Childhood, Adolescence and Adulthood

Yuki Nouchi
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
2   Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Eiji Munetsuna
3   Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Hiroya Yamada
4   Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Mirai Yamazaki
5   Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Kagawa, Japan
,
Yoshitaka Ando
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Genki Mizuno
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
2   Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Ryosuke Fujii
2   Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Itsuki Kageyama
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
2   Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Takuya Wakasugi
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Tomohide Sakakibara
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Atsushi Teshigawara
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Hiroaki Ishikawa
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Yohei Shimono
3   Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Koji Suzuki
2   Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
,
Shuji Hashimoto
4   Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Koji Ohashi
1   Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan
› Institutsangaben Funding Financial support for this study was provided by JSPS KAKENHI Grant Number (20H04134).
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Abstract

The consumption of high-fructose corn syrup (HFCS) has been increasing in recent decades, especially among children. Some reports suggest that children and adolescents are more sensitive to the adverse effects of fructose intake than adults. However, the underlying mechanism of the difference in vulnerability between adolescence and adulthood have not yet been elucidated. In this study, we attempted to elucidate the different effects of HFCS intake at different growth stages in rats: childhood and adolescence (postnatal day (PD) 21–60), young adulthood (PD60–100), and adulthood (PD100–140). Since alterations in hepatic glucocorticoid (GC) metabolism can cause diseases including insulin resistance, we focused on GC metabolizing enzymes such as 11 beta-hydroxysteroid dehydrogenase 1 and 2 (Hsd11b1 and Hsd11b2) and steroid 5 alpha-reductase 1 (Srd5a1). Western blotting showed an increase in Hsd11b1 expression and a decrease in Hsd11b2 expression in childhood and adolescence but not in adulthood. We also observed changes in Hsd11b1 and Hsd11b2 activities only in childhood and adolescence, consistent with the results of mRNA and protein expression analysis. The effect of high-fructose intake with regards to GC metabolism may therefore vary with developmental stage. This study provides insight into the adverse effects of fructose on GC metabolism in children in the context of increasing rates of HFCS consumption.

Key words

11 beta-hydroxysteroid dehydrogenase - steroid 5 alpha-reductase 1 - corticosterone - metabolic disorders - sugar

Supplementary Material



Publikationsverlauf

Eingereicht: 22. April 2022
Eingereicht: 19. August 2022

Angenommen: 25. August 2022

Artikel online veröffentlicht:
11. November 2022

© 2022. Thieme. All rights reserved.

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