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CC BY-NC-ND 4.0 · SynOpen 2022; 06(04): 286-305
DOI: 10.1055/a-1929-9789
DOI: 10.1055/a-1929-9789
Graphical Review
Transition-Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines
Financial support from the National Natural Science Foundation of China (NSFC) (Grant no. 22101206) and the Fundamental Research Funds for the Central Universities (Grant no. 22120220087) is gratefully acknowledged.
Abstract
C–H bond functionalization is one of the most effective strategies for the rapid synthesis of cyclic amines containing substituents on the ring, which are core structures of many bioactive molecules. However, it is much more challenging to perform this strategy on remote C–H bonds compared to the α-C–H bonds of cyclic amines. This graphical review aims to provide a concise overview on transition-metal-catalyzed methods for the remote C–H bond functionalization of cyclic amines. Examples are categorized and demonstrated according to mechanistic pathways that initiate the reactions of cyclic amine substrates. Where relevant, selected substrate scope and detailed reaction mechanisms are given.
Key words
C–H bond functionalization - remote - cyclic amines - transition metals - catalysis - synthesisPublication History
Received: 09 August 2022
Accepted after revision: 23 August 2022
Accepted Manuscript online:
24 August 2022
Article published online:
24 October 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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