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Horm Metab Res 2022; 54(09): 604-612
DOI: 10.1055/a-1903-1943
Original Article: Endocrine Care

Geriatric Nutritional Risk Index as a Prognostic Factor of Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Ming Yang
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
,
Zhaohui Liu
2   Nursing Department, Cangzhou Central Hospital, Cangzhou, China
,
Guojing Li
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
,
Bing Li
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
,
Chao Li
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
,
Lianbo Xiao
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
,
Jiwu Zhou
1   Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Cangzhou, China
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Abstract

Geriatric nutritional risk index (GNRI), a newly developed indicator of nutritional status retrieved by serum albumin concentration and ideal body weight, has been suggested as a prognostic factor for various malignancies. The aim of the study was to summarize the prognostic role of GNRI for patients with non-small cell lung cancer (NSCLC) in a meta-analysis. Cohort studies evaluating the relationship between GNRI at baseline and survival OF NSCLC were retrieved by search of PubMed, Embase, and Web of Science databases from inception to January 12, 2022. A conservative random-effect model incorporating the possible influence of between-study heterogeneity was used to pool the results. Eleven cohorts including 2865 patients with NSCLC were included. Compared to those with higher GNRI, NSCLC patients with lower GNRI were associated with poorer overall survival [OS, hazard ratio (HR): 2.39, 95% CI: 1.97–2.91, p<0.001; I2=29%), progression-free survival (HR: 1.94, 95% CI: 1.52–2.47, p<0.001; I2=29%), and cancer-specific survival (HR: 2.59, 95% CI: 1.55–4.35, p<0.001; I2=0%). Subgroup analyses showed that the significant association between lower GNRI and worse OS in patients with NSCLC was not affected by study characteristics including study location, design, cancer stage, treatment, or follow-up durations (p for subgroup effects all<0.001). In conclusion, a lower GNRI in patients with NSCLC may be a predictor of poor survival. Nutritional status indicated by GNRI may be important for the prognostic prediction of patients with NSCLC.

Key words

geriatric nutritional risk index - non-small cell lung cancer - survival - predict - meta-analysis


Publication History

Received: 15 May 2022

Accepted after revision: 11 July 2022

Article published online:
07 September 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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