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DOI: 10.1055/a-1892-9671
Synthetic Tools that Enable Synthesis and Understanding of Bioactive Macrocycles
The Natural Science and Engineering Research Council of Canada is gratefully acknowledged for financial support of this work.
![](https://www.thieme-connect.de/media/synlett/202219/lookinside/thumbnails/st-2022-a0290-a_10-1055_a-1892-9671-1.jpg)
In memory of Eric Marsault
Abstract
This article aims to summarizing the evolution of my lab’s research efforts in making and understanding peptide macrocycles. What started as a curiosity-driven investigation of amphoteric structures in multicomponent reactions, has turned into a sustained exploration of complex macrocyclic peptides. As part of this journey, my students and I have introduced new tools that enable chemical synthesis and property-driven optimization of cyclic peptides. These contributions are expected to be relevant in the areas of drug discovery and biological probe design.
Publication History
Received: 22 June 2022
Accepted after revision: 06 July 2022
Accepted Manuscript online:
06 July 2022
Article published online:
12 August 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
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