Construction of Quaternary Allylic Amino Acid Derivatives through Palladium-Catalyzed Allylic Alkylation Reaction of Azlactones with Vinyl Aziridine

Abstract

A highly efficient Pd-catalyzed allylic alkylation reaction of azlactones with vinyl aziridine has been achieved for the first time to access­ functionalized quaternary allylic amino acid derivatives (17 examples, up to 89% yield and 80% ee). Moreover, the broad scope and easy transformations of the products reinforce the value of this approach, which can enrich the chemistry of quaternary allylic amino acid derivatives.

Key words

allylic alkylation - quaternary allylic amino acid derivatives - Pd-catalyzed - vinyl aziridine - azlactones

Publikationsverlauf

Eingereicht: 15. April 2022

Angenommen nach Revision: 20. Juni 2022

Accepted Manuscript online:
20. Juni 2022

Artikel online veröffentlicht:
27. Juli 2022

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