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Exp Clin Endocrinol Diabetes 2022; 130(10): 671-677
DOI: 10.1055/a-1861-2388
Review

Advanced Glycation End Products, Bone Health, and Diabetes Mellitus

Jingjing Jiang
1   School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
,
Changyu Zhao
1   School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
,
Tingting Han
2   State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China
,
Hongyan Shan
1   School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
,
Guiyou Cui
1   School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
,
Songnan Li
3   Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, P. R. China
,
Zhongwen Xie
2   State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China
,
Jun Wang
1   School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
2   State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (NO. 82000791), the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization (NO. SKLTOF20200110), and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (Yangzhou University) (NO. KYCX21_3292).
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Abstract

Advanced glycation end products (AGEs), the compounds resulting from the non-enzymatic glycosylation between reducing sugars and proteins, are derived from food or produced de novo. Over time, more and more endogenous and exogenous AGEs accumulate in various organs such as the liver, kidneys, muscle, and bone, threatening human health. Among these organs, bone is most widely reported. AGEs accumulating in bone reduce bone strength by participating in bone structure formation and breaking bone homeostasis by binding their receptors to alter the proliferation, differentiation, and apoptosis of cells involved in bone remodeling. In this review, we summarize the research about the effects of AGEs on bone health and highlight their associations with bone health in diabetes patients to provide some clues toward the discovery of new treatment and prevention strategies for bone-related diseases caused by AGEs.

Key words

Advanced glycation end products - Bone remodeling - Bone fragility - Diabetes


Publication History

Received: 09 February 2022
Received: 11 May 2022

Accepted: 16 May 2022

Article published online:
18 October 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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