Recent Advances in the Synthesis and Medicinal Chemistry of SF₅ and SF₄Cl Compounds

Abstract

This short review covers the most important advances published in the literature during the last five years, concerning the synthesis, chemical modifications, and applications of SF₅ and SF₄Cl compounds in medicinal/bioorganic chemistry and materials science.

1 Introduction

2 Methods for Incorporation/Manipulation of SF₄Cl/SF₅ Groups

2.1 Nonaromatic SF₅ Compounds via Direct Pentafluorosulfanylation of Alkenes and Alkynes

2.2 SF₄Cl- and SF₅-Aryl/Heteroaryl Derivatives

3 Synthesis of SF₅/SF₄Cl/SF₄-Substituted Small Molecules

3.1 Heterocycles

3.2 Amines and Amino Acids

3.3 α-SF₅ ketones

3.4 Miscellaneous Alkyl-, Alkenyl-, and Aryl-SF₅ Compounds

4 Medicinal/Biological Applications

4.1 Anticancer Compounds

4.2 Antibacterial and Antiparasitic Compounds

4.3 Central Nervous System

4.4 Miscellaneous Biological Activity

5 Materials Science Applications

6 Conclusion

Key words

pentafluorosulfanyl - chlorotetrafluorosulfanyl - synthesis - applications - materials Science - medicinal Chemistry - biological activity

Publication History

Received: 01 April 2022

Accepted after revision: 06 May 2022

Accepted Manuscript online:
06 May 2022

Article published online:
21 June 2022

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