Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

Abstract

The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.

Key words

Nanomedicines - Nanotechnology - Bioavailability - Drug Delivery - Toxicity - Nanomaterials

Publication History

Received: 20 September 2021

Accepted: 05 April 2022

Article published online:
30 May 2022

• References

• 1 Alsehli M. Polymeric nanocarriers as stimuli-responsive systems for targeted tumor (cancer) therapy: Recent advances in drug delivery. S Pharma J 2020; 28: 255-265 DOI: 10.1016/j.jsps.2020.01.004.
• 2 Badar A, Pachera S, Ansari AS, Lohiya NK. Nano Based Drug Delivery Systems: Present and Future Prospects. Nano Nanotech J 2019; 2: 19-121
• 3 Manzari MT, Shamay Y, Kiguchi H. et al., Targeted drug delivery strategies for precision medicines. Nat Rev Mater 2021; 6: 351-370 DOI: 10.1038/s41578-020-00269-6.
• 4 Ayub A, Wettig S. An Overview of Nanotechnologies for Drug Delivery to the Brain. Pharmaceutics 2022; 14: 224 DOI: 10.3390/pharmaceutics14020224.
• 5 Nakamura Y, Mochida A, Choyke PL, Kobayashi H. Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer ?. Bioc. Chem 2016; 27: 2225-2238 DOI: 10.1021/acs.bioconjchem.6b00437.
• 6 Fang J. EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer. J Pers Med 2022; 12: 95 DOI: 10.3390/jpm12010095.
• 7 Majhi KC, Yadav M. Synthesis of inorganic nanomaterials using carbohydrates in Green Sustainable Process for Chemical and Environmental Engineering and Science. 2021
• 8 Nabipour H, Hu Y. Sustainable drug delivery systems through green nanotechnology. Nanoeng Biomat Adv. Drug Delivery 2020; 61-89 DOI: 10.1016/b978-0-08-102985-5.00004-8.
• 9 Bhattacharya T, Soares GAB, Chopra H, Rahman MM, Hasan Z, Swain SS, Cavalu S. Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders. Materials 2022; 15: 804 DOI: 10.3390/ma15030804.
• 10 Kate A, Sahu LK. Green Catalysis for Chemical Transformation: The Need for the Sustainable development. Cur Res Green Sust Chem 2021; 5: 100248 DOI: 10.1016/j.crgsc.2021.
• 11 Sharma PK, Sharma HP, Chakole CM, Pandey J, Chauhan MK. Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient. J Ind Chem Soc 2022; 99: 100387 DOI: 10.1016/j.jics.2022.100387.
• 12 Rizvi SAA, Saleh AM. Applications of nanoparticle systems in drug delivery technology. S Pharma J 2018; 26: 64-70 DOI: 10.1016/j.jsps.2017.10.012.
• 13 Chowdhury A, Kunjiappan S, Panneerselvam T, Somasundaram B, Bhattacharjee C. Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases. Int Nano Lett 2017; 7: 91-122 DOI: 10.1007/s40089-017-0208-0..
• 14 Ma X, Williams RO. Polymeric nanomedicines for poorly soluble drugs in oral delivery systems: an update. J Pharma Investig 2018; 48: 61-75 DOI: 10.1007/s40005-017-0372-2.
• 15 Farshbaf M, Valizadeh H, Panahi Y, Fatahi Y. et al. The impact of protein corona on the biological behavior of targeting nanomedicines. Int J Pharma 2022; 614 DOI: 10.1016/j.ijpharm.2022.121458.
• 16 Mitchell MJ, Billingsley MM, Haley RM. et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov 2021; 101-124 DOI: 10.1038/s41573-020-0090-8.
• 17 Salvati A, Poelstra K. Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation. Pharmaceutics 2022; 14: 217 DOI: 10.3390/pharmaceutics14010217.
• 18 Attia MF, Anton N, Wallyn J, Omran Z, Vandamme TF. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J Pharma Pharmaco 2019; 221-224 DOI: 10.1111/jphp.13098.
• 19 Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotech 2015; 33: 941-951 DOI: 10.1038/nbt.3330.
• 20 Karimi M, Ghasemi A, Sahandi Z. et al. Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev 2016; 45: 1457-1501 DOI: 10.1039/c5cs00798d.
• 21 Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin HS. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology 2018; 16: 71 DOI: 10.1186/s12951-018-0392-8..
• 22 Abid N, Khan AM, Shujait S. et al. Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: A review. Adv Colloid Inter Sci 2022; 300 DOI: 10.1016/j.cis.2021.102597.
• 23 McCarron E, Chambers G. A review of suitable analytical technology for physio-chemical characterisation of nanomaterials in the customs laboratory. Talanta Open 2022; 4: 227 DOI: 10.1016/j.talo.2021.100069.
• 24 Behera A. Nanomaterials. Adv Mat 2021; 77-125 DOI: 10.1007/978-3-030-80359-9_3.
• 25 Scott SM, Ali Z. Fabrication Methods for Microfluidic Devices: An Overview. Micromachines 2021; 12: 319 DOI: 10.3390/mi12030319.
• 26 Ealias AM, Saravanakumar MP. A review on the classification, characterisation, synthesis of nanoparticles and their application. IOP Conference Series: Mat Sci Eng 2017; 263 DOI: 10.1088/1757-899X/263/3/032019.
• 27 Anik MI, Hossain MK, Hossain I, Mahfuz AMUB, Rahman MT, Ahmed I. Recent progress of magnetic nanoparticles in biomedical applications: A review. Nano Select 2021; 2: 1146-1186 DOI: 10.1002/nano.202000162.
• 28 Jain AK, Thareja S. In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery. Artificial Cells. Nanomed Biotech 2019; 47: 524-539 DOI: 10.1080/21691401.2018.1561457.
• 29 Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein, J Nanotech 2018; 9: 1050-1074 DOI: 10.3762/bjnano.9.98.
• 30 Raliya R, Chadha TS, Hadad K, Biswas P. Perspective on nanoparticle technology for biomedical use. Curr Pharma Des 2016; 22 DOI: 10.2174/1381612822666160307151409.
• 31 Mukherji S, Bharti S, Shukla G, Mukherji S. Synthesis and characterization of size- and shape-controlled silver nanoparticles. Phys Sci Rev 2018; DOI: 10.1515/psr-2017-0082.
• 32 Shelma R. Polymeric Nanoparticles for Drug Delivery, A Holistic and Integrated Approach to Lifestyle Diseases. CRC Press; 2022: 319-332
• 33 Castro K, De C, Costa JM, Campos MGN. Drug-loaded polymeric nanoparticles: a review. Int J Poly Mat Poly Biomat 2022; 71: 1-13
• 34 Rai S, Singh N, Bhattachary S. Concepts on smart nano-based drug delivery system. Recent pat nanotech 2021; 19: 321-330
• 35 Bodratti A, Alexandridis P. Formulation of Poloxamers for Drug Delivery. J Funct Biomat 2018; 9: 11-17 DOI: 10.3390/jfb9010011.
• 36 Chen L, Hong W, Ren W. et al. Recent progress in targeted delivery vectors based on biomimetic nanoparticles. Sig Transduct Target Ther 2021; 6: 225-229 DOI: 10.1038/s41392-021-00631-2.
• 37 Ibrahim MA, Abdellatif AA. Applications of nanopharmaceuticals in delivery and targeting. Nanopharmaceuticals: Prin Appl. Springer; Cham: 2021. 1. 73-114
• 38 Zhang Z, Jianping YUQ, Wu W. An update on oral drug delivery via intestinal lymphatic transport. Acta Pharmaceutica Sinica 2021; 11: 2449-2468
• 39 Senthilkumar N, Sharma PK, Sood N, Bhalla N. Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body. Coord Chem Rev 2021; 445 DOI: 10.1016/j.ccr.2021.214082.
• 40 McGuckin MB, Wang J, Ghanma R. et al. Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes. J Cont Release 2022; 521-525 DOI: 10.1016/j.jconrel.2022.03.012.
• 41 Farah D, Umer F, Nainan D. Applications of Nanoparticles in Treatment of Respiratory Disorders. Life and Sci 2022; 3: 8-11
• 42 Itani R, Faraj A. siRNA Conjugated Nanoparticles – A Next Generation Strategy to Treat Lung Cancer. Int J Mol Sci 2019; 20: 6088 DOI: 10.3390/ijms20236088.
• 43 Yadav K, Pradhan M, Singh D, Singh MR. Targeting autoimmune disorders through metal nanoformulation in overcoming the fences of conventional treatment approaches. Int Trans Autoimmunity 2022; 361-393
• 44 Hong S, Dong WC, Hong NK, Chun GP. et al. Protein-based nanoparticles as drug delivery systems. Pharmaceutics 2020; 12: 604-607
• 45 Khan ME. State-of-the-art developments in carbon-based metal nanocomposites as a catalyst: photocatalysis. Nano Adv 3 2021; 7: 1887-1900
• 46 Fan Y, Hou Y, Wang M, Zheng J, Hou X. Bioinspired carbon nanotubes-based materials, Materials Advances. 2022; 8: 773-779
• 47 Simon J, Flahaut E, Golzio M. Overview of Carbon Nanotubes for Biomedical Applications. Materials 2019; 12: 624-628 DOI: 10.3390/ma12040624.
• 48 Rathinavel S, Priyadharshini K, Panda D. A review on carbon nanotube: An overview of synthesis, properties, functionalization, characterization, and the application. Mat Sci Eng: B 2021; 268: 664-667 DOI: 10.1016/j.mseb.2021.115095.
• 49 Chakole CM, Sahoo PK, Pandey J, Chauhan MK. A green chemistry approach towards synthesizing hydrogel for sustained ocular delivery of brinzolamide: In vitro and ex vivo evaluation. J Ind Chem Soc 2022; 99: 323-336 DOI: 10.1016/j.jics.2021.100323.
• 50 Mahender M, Pandey J, Reddy A. Stereoselective Synthesis for Potential Isomers of Ticagrelor Key Starting Material. J Hetero Chem 2019; 56: 2866-2872 DOI: 10.1002/jhet.3677.
• 51 Yaqoob AA, Ahmad H, Parveen T, Ahmad A, Oves M, Ismail I, Qari HA, Umar K, Mohamad MMN. Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review. Front Chem 2020; 8: 341-344 DOI: 10.3389/fchem.2020.00341.
• 52 Jeyaraj M, Gurunathan S, Qasim M, Kang MH, Kim JH. A Comprehensive Review on the Synthesis, Characterization, and Biomedical Application of Platinum Nanoparticles. Nanomaterials 2019; 9: 1719-1723 DOI: 10.3390/nano9121719.
• 53 Irfan I, Ezaz G, Ammara N, Aysha N. Detail review on chemical, physical and green synthesis, classification, characterizations and applications of nanoparticles. Green Chem Lett Rev 2020; 13: 853-856 DOI: 10.1080/17518253.2020.1802517.
• 54 Nikolova MP, Chavali MS. Metal Oxide Nanoparticles as Biomedical Materials. Biomimetics 2020; 5: 27-31 DOI: 10.3390/biomimetics5020027.
• 55 Fernandes F, Dias-Teixeira M, Delerue-Matos C, Grosso C. Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts. Nanomaterials 2021; 11: 563-566 DOI: 10.3390/nano11030563.
• 56 Din FU, Aman W, Ullah I, Qureshi OS. et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomed 2017; 12: 7291-7309 DOI: 10.2147/IJN.S146315.
• 57 Singh N, Pandey J. Advances in Henry Reaction: A Versatile Method in Organic Synthesis. Mini Rev Org Chem 2019; 16: 1-12 DOI: 10.2174/1570193X16666190214150144.
• 58 Datta R, Jaitawat SS. Nanotechnology – The new frontier of medicine. Med J Armed Forces India 2016; 62: 263-268 DOI: 10.1016/S0377-1237(06)80016-X.
• 59 Pamidimarri SD, Velramar B, Madavi T, Pandey S, Ratre YK, Sharma PK, Chauhan S. Quantum Dots: Characteristics and Prospects from Diagnosis to Treatment. Eng Nanomat for Innov Thera Biomed 2022; 5: 175-204
• 60 Wagner AM, Knipe JM, Orive G, Peppas NA. Quantum dots in biomedical applications. Acta Biomat 2019; 94: 44-63 DOI: 10.1016/j.actbio.2019.05.022.
• 61 Tandale P, Choudhary N, Singh J, Sharma A. et al. Fluorescent quantum dots: An insight on synthesis and potential biological application as drug carrier in cancer. Biochem Biophys Rep 2021; 26: 230-233 DOI: 10.1016/j.bbrep.2021.100962.
• 62 Khanna K. Targeted Delivery of Nanomedicines. ISRN Pharma 2012; 1-9 DOI: 10.5402/2012/571394.
• 63 Pablo VV, Mosier NS, Irudayaraj J. Nanoscale Drug Delivery Systems: From Medicine to Agriculture. Front Bioeng Biotech 2020; 8: 79-81 DOI: 10.3389/fbioe.2020.00079.
• 64 Ahuja A, Narde GK, Wadi N, Meenakshi DU. Drug Targeting Approaches and Use of Drug Delivery Systems in Management of Cancer. Cur Pharma Des 2021; 27: 4593-4609
• 65 Bhatia S. Natural polymer drug delivery systems: Nanoparticles. plants, and algae 2016; DOI: 10.1007/978-3-319-41129-3.
• 66 Forest V, Pourchez J. Nano-delivery to the lung-by inhalation or other routes and why nano when micro is largely sufficient?. Adv Drug Del Rev 2022; 8: 114-173.
• 67 Yoo J, Park C, Yi G, Lee D, Koo H. Active targeting strategies using biological ligands for nanoparticle drug delivery systems. Cancers 2021; 11: 345-349 DOI: 10.3390/cancers11050640.
• 68 Kheirkhah P, Denyer S, Bhimani AD. et al. Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors. Sci Rep 2018; 8: 11417-11421 DOI: 10.1038/s41598-018-29736-5.
• 69 Sarwar H, Khalid M, Basher M, Mia M, Rahman M, Jalal Udhin M. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review. J Adv Res 2019; 15: 1-18 DOI: 10.1016/j.jare.2018.06.005.
• 70 Kunjiappan S, Pavadai P, Vellaichamy S. et al. Surface receptor-mediated targeted drug delivery systems for enhanced cancer treatment: A state-of-the-art review. Drug Devel Res 2021; 82: 309-340
• 71 Glassman PM, Hood ED, Ferguson LT. et al. Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers. Adv Drug Del Rev 2021; 178: 113992-113999
• 72 Sahu T, Ratre YK, Chauhan S, Bhaskar LV, Nair MP, Verma HK. Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science. J Drug Del Sci Tech 2021; 63: 102487
• 73 Pandian SRK, Theivendren P, Ravishankar V. et al. Emerging Nanomaterials for Cancer Targeting and Drug Delivery, Eng Nanomat Innov Therap Biomed. 2022; 7: 343-372
• 74 Khan MI, Hossain MI, Hossain MK. et al. Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review. ACS Appl Bio Mat 2022; 18: 132-151.
• 75 Szlasa W, Zendran I. et al. Lipid composition of cancer cells membrane. J. Bioeng. Biomemb 2020; 52: 321-342
• 76 Yaman S, Chintapula U, Rodriguez E, Ramachandramoorthy H, Nguyen KT. Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy. Cancer Drug Resist 2020; 3: 879-911 DOI: 10.20517/cdr.2020.55.
• 77 Raj S, Khurana S, Choudhari R, Kesari KK, Kamal MA, Garg N, Kumar D. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Seminars in cancer biology 2021; 69: 166-177
• 78 Russo J. Defining Breast Cancer. The Future of Prevention and Treatment of Breast Cancer 2021; 1-31
• 79 Farshad M, Mehdi B, Anvar S, Roghayyeh Vakili-G, Mahmoud Reza J, Mohammad S. A review on liposome-based therapeutic approaches against malignant melanoma. Int J Pharma 2021; 599: 120413-120417 DOI: 10.1016/j.ijpharm.2021.120413.
• 80 Krzyszczyk P. The growing role of precision and personalized medicine for cancer treatment. Technology 2018; 6: 79-100 DOI: 10.1142/S2339547818300020.
• 81 Ghosh S, Jayaram P, Kabekkodu SP, Satyamoorthy K. Targeted drug delivery in cervical cancer: Current perspectives. Europ J Pharma 2022; 174751-174755
• 82 Yadav A, Singh S, Sohi H. et al. Advances in Delivery of Chemotherapeutic Agents for Cancer Treatment. AAPA Pharma Sci Tech 2022; 23: 25-41
• 83 Eunus A, Shazid S, Torequl M, Ishaq K, Subrata S, Atiqur R, Jamal Uddin S, Manik Chandra S, Shahnawaz R, Niranjan D, Saheem A, Jamil S, Swati T, Siddhartha M, Mubarak M. Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives. Seminars in Cancer Biology 2021; 69: 52-68 DOI: 10.1016/j.semcancer.2020.01.011.
• 84 Arora G, Shrivastava R, Kumar P, Krishnamurthy D, Matharu AS. Recent advances made in the synthesis of small drug molecules for clinical applications: An insight. Curr Res Green Sust Chemi 2021; 4: 120032-120038 DOI: 10.1016/j.crgsc.2021.100097.
• 85 Joseph X, Akhil V, Arathi A, Mohanan PV. Nanobiomaterials in support of drug delivery related issues. Mat Sci Eng: B 2022; 279: 115680-115688
• 86 Zhang X, Zhou J, Gu Z, Zhang H, Gong Q, Luo K. Advances in nanomedicines for diagnosis of central nervous system disorders. Biomaterials 2021; 269: 120492-120500
• 87 Navya PN, Kaphle A, Srinivas SP. et al. Current trends and challenges in cancer management and therapy using designer nanomaterials. Nano Convo 2019; 6: 23-17
• 88 Patel J, Patel A, Patel M, Vyas G. Introduction to Nanoparticulate Drug Delivery Systems. Pharma Pharmacodyn Nano Drug Del Syst 2022; 3-23
• 89 Nelemans L, Leonid G. Drug Delivery with Polymeric Nanocarriers, Cellular Uptake Mechanisms. Materials 2020; 13: 366-370 DOI: 10.3390/ma13020366.
• 90 Gauro R, Nandave M, Jain VK. et al. Advances in dendrimer- mediated targeted drug delivery to the brain. J Nanopart Res 2021; 23: 76-79
• 91 Lembo D, Donalisio M, Civra A, Argenziano M, Cavalli R. Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections. Expert Opinion on Drug Delivery 2018; 15: 93-114
• 92 Wei X, Gang Z, Ran D, Nishta K. et al. T-Cell-Mimicking Nanoparticles Can Neutralize HIV Infectivity. Adv Mat 2018; 30: 1802233 DOI: 10.1002/adma.201802233.
• 93 Wang J, Ni Q, Wang Y, Zhang Y, He H, Gao D, Liang XJ. Nanoscale drug delivery systems for controllable drug behaviours by multi-stage barrier penetration. J Cont Release 2021; 331: 282-295