Sonografisches Neuromonitoring auf der Stroke Unit und in der neurologischen Intensivmedizin

Zusammenfassung

Hintergrund Der Artikel gibt einen Überblick über die aktuellen diagnostischen Einsatzmöglichkeiten sonographischer Anwendung in der neurologischen Intensivmedizin.

Methoden Selektive Literaturrecherche mit kritischer Beurteilung ab dem Jahr 1984 sowie nationaler und internationaler Leitlinien sowie Expertenmeinung.

Ergebnisse Neben der raschen validen Abklärung akuter Schlaganfälle bieten verschiedene neurosonografische Monitoring-verfahren gerade in der Intensivmedizin spezifische Vorteile wie die beliebig häufige Wiederholbarkeit am Patientenbett selbst und die Darstellung in Echtzeit. Innovative Entwicklungen machen die Neurosonografie auch wissenschaftlich zu einem interessanten Gebiet.

Schlussfolgerung Die neurosonografische Diagnostik nimmt seit Jahren einen wichtigen Stellenwert in der neurologischen Intensivmedizin ein. Weitere Anstrengungen sind notwendig, um die Verbreitung der Methode zu fördern und durch wissenschaftliche Evidenz zu stärken.

Abstract

Background To give an up-to-date overview of neurosonographic diagnostics in intensive care medicine.

Methods Selective literature research with critical appraisal from 1984 on including national and international guidelines, and expert opinion.

Results Fast and valid diagnostics in acute stroke is the main field of application of neurosonography. Specific sonographic monitoring methods bear great advantages for intensive care patients, especially “as-often-as-wanted” repetitive imaging under real-time conditions. A number of new developments make neurosonography an interesting area of research.

Conclusion Neurosonography has a key role in neurologic intensive care medicine since many years. It remains important to continuously spread the methods further and strengthen its validity by scientific evidence.

Schlüsselwörter

transkranielle Sonografie - extrakraniale Sonografie - Schlaganfall - Karotisstenose - Hirndruck - Hirntod

Key words

transcranial sonography - extracranial sonography - stroke - carotid stenosis - increased intracranial pressure - brain death

Publikationsverlauf

Artikel online veröffentlicht:
09. Juni 2022

• Literatur

• 1 Bonow RH, Young CC, Bass DI, Moore A, Levitt MR. Transcranial Doppler ultrasonography in neurological surgery and neurocritical care. Neurosurg Focus 2019; 47: E2
• 2 Rasulo FA, Bertuetti R. Transcranial Doppler and Optic Nerve Sonography. J Cardiothorac Vasc Anesth 2019; 33: S38-S52
• 3 Baracchini C, Pieroni A, Kneihsl M, Azevedo E, Diomedi M, Pascazio L, Wojczal J, Lucas C, Bartels E, Bornstein NM. et al. Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic: an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics. Eur J Neurol 2020; 27: 1776-1780
• 4 Parmentier-Decrucq E, Poissy J, Favory R, Nseir S, Onimus T, Guerry MJ, Durocher A, Mathieu D. Adverse events during intrahospital transport of critically ill patients: incidence and risk factors. Ann Intensive Care 2013; 3: 10
• 5 Harrer JU, Eyding J, Ritter M, Schminke U, Schulte-Altedorneburg G, Kohrmann M, Nedelmann M, Schlachetzki F. The potential of neurosonography in neurological emergency and intensive care medicine: monitoring of increased intracranial pressure, brain death diagnostics, and cerebral autoregulation – part 2. Ultraschall Med 2012; 33: 320-331 quiz 332-326
• 6 Harrer JU, Eyding J, Ritter M, Schminke U, Schulte-Altedorneburg G, Kohrmann M, Nedelmann M, Schlachetzki F. The potential of neurosonography in neurological emergency and intensive care medicine: basic principles, vascular stroke diagnostics, and monitoring of stroke-specific therapy – Part 1. Ultraschall Med 2012; 33: 218-232 quiz 233-215
• 7 Baumgartner RW, Baumgartner IB. Transcranial Doppler and color duplex ultrasound. Familiar and new uses. Ultraschall Med 1996; 17: 50-54
• 8 Sauerbruch S, Schlachetzki F, Bogdahn U, Valaikiene J, Hölscher T, Harrer JU. Application of Transcranial Color-Coded Duplex Sonography in Stroke Diagnosis. Current Medical Imaging Reviews 2009; 5: 39-54
• 9 Wannamaker R, Buck B, Butcher K. Multimodal CT in Acute Stroke. Curr Neurol Neurosci Rep 2019; 19: 63
• 10 Campbell BC, Parsons MW. Imaging selection for acute stroke intervention. Int J Stroke 2018; 13: 554-567
• 11 Psychogios K, Magoufis G, Kargiotis O, Safouris A, Bakola E, Chondrogianni M, Zis P, Stamboulis E, Tsivgoulis G. Ultrasound Assessment of Extracranial Carotids and Vertebral Arteries in Acute Cerebral Ischemia. Medicina (Kaunas) 2020; 56: 12
• 12 Gomez JR, Hobbs KS, Johnson LL, Vu QD, Bennett J, Tegeler C, Wolfe SQ, Sarwal A. The Clinical Contribution of Neurovascular Ultrasonography in Acute Ischemic Stroke. J Neuroimaging 2020; 30: 867-874
• 13 Eyding J, Reitmeir R, Oertel M, Fischer U, Wiest R, Gralla J, Raabe A, Zubak I, ZG W, Beck J. Ultrasonic quantification of cerebral perfusion in acute anterior circulation occlusive stroke-A comparative challenge of the refill- and the bolus-kinetics approach. PLoS One 2019; 14: e0220171
• 14 Taroza S, Valaikiene J, Schlachetzki F, Knokneris A. Embolic Middle Cerebral Artery Occlusion from Innominate Artery Stenosis: Successful Mechanical Recanalisation. J NEUROL NEUROSCIENCE 2016; 7: 81
• 15 Aboyans V, Lacroix P, Jeannicot A, Guilloux J, Bertin F, Laskar M. A new approach for the screening of carotid lesions: a ‘fast-track’ method with the use of new generation hand-held ultrasound devices. Eur J Vasc Endovasc Surg 2004; 28: 317-322
• 16 Connolly F, Rohl JE, Guthke C, Wengert O, Valdueza JM, Schreiber SJ. Emergency Room Use of “Fast-Track” Ultrasound in Acute Stroke: An Observational Study. Ultrasound Med Biol 2019; 45: 1103-1111
• 17 Kargiotis O, Safouris A, Magoufis G, Georgala M, Roussopoulou A, Stamboulis E, Moulakakis KG, Lazaris A, Geroulakos G, Vasdekis S. et al. The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. J Neuroimaging 2018; 28: 239-251
• 18 Eyding J, Geier B, Staub D. Current strategies and possible perspectives of ultrasonic risk stratification of ischemic stroke in internal carotid artery disease. Ultraschall Med 2011; 32: 267-273
• 19 Yan H, Wu X, He Y, Staub D, Wen X, Luo Y. Carotid Intraplaque Neovascularization on Contrast-Enhanced Ultrasound Correlates with Cardiovascular Events and Poor Prognosis: A Systematic Review and Meta-analysis. Ultrasound Med Biol 2021; 47: 167-176
• 20 Rodallec MH, Marteau V, Gerber S, Desmottes L, Zins M. Craniocervical arterial dissection: spectrum of imaging findings and differential diagnosis. Radiographics 2008; 28: 1711-1728
• 21 Dittrich R, Ritter MA, Kaps M, Siebler M, Lees K, Larrue V, Nabavi DG, Ringelstein EB, Markus HS, Droste DW. The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial. Stroke 2006; 37: 1065-1069
• 22 Tsivgoulis G, Alexandrov AV. Ultrasound in Neurology. Continuum (Minneap Minn) 2016; 22 5, Neuroimaging 1655-1677
• 23 Seliger C, Turmanidze N, Schmid E, Wietholter H, Boy S, Bogdahn U, Kaiser B, Schlachetzki F. Three cases of stroke in patients with atypical presentation of type a aortic dissection–potential of neurosonography in the early diagnosis of atypical stroke. Ultraschall Med 2011; 32: 619-621
• 24 Arning C, Widder B, von Reutern GM, Stiegler H, Gortler M. [Revision of DEGUM ultrasound criteria for grading internal carotid artery stenoses and transfer to NASCET measurement]. Ultraschall Med 2010; 31: 251-257
• 25 Eyding J, Geier B, Staub D. Current Strategies and Possible Perspectives of Ultrasonic Risk Stratification of Ischemic Stroke in Internal Carotid Artery Disease. Ultraschall Med 2011; 32: 267-273
• 26 Jahromi AS, Cina CS, Liu Y, Clase CM. Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis. J Vasc Surg 2005; 41: 962-972
• 27 Dorigo W, Pulli R, Nesi M, Alessi Innocenti A, Pratesi G, Inzitari D, Pratesi C. Urgent carotid endarterectomy in patients with recent/crescendo transient ischaemic attacks or acute stroke. Eur J Vasc Endovasc Surg 2011; 41: 351-357
• 28 Shahidi S, Owen-Falkenberg A, Hjerpsted U, Rai A, Ellemann K. Urgent best medical therapy may obviate the need for urgent surgery in patients with symptomatic carotid stenosis. Stroke 2013; 44: 2220-2225
• 29 Azhar B, Wafi A, Budge J, Loftus I. Timing of carotid endarterectomy and clinical outcomes. Ann Transl Med 2020; 8: 1267
• 30 Lawaetz M, Sandholt B, Eilersen EN, Petersen C, Torslev K, Shilenok D, Houlind KC, Sillesen H, Shahidi S, Rathenborg LK. et al. Low Risk of Neurological Recurrence while Awaiting Carotid Endarterectomy: Results From a Danish Multicentre Study. Eur J Vasc Endovasc Surg 2021; 62: 160-166
• 31 Naylor AR, Ricco JB, de Borst GJ, Debus S, de Haro J, Halliday A, Hamilton G, Kakisis J, Kakkos S, Lepidi S. et al. Editor’s Choice - Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg 2018; 55: 3-81
• 32 https://www.awmf.org/uploads/tx_szleitlinien/004-028l_extracranielle-Carotisstenose-Diagnostik-Therapie-Nachsorge_2020-02_03.pdf
• 33 Paraskevas KI, Mikhailidis DP, Antignani PL, Baradaran H, Bokkers RPH, Cambria RP, Dardik A, Davies AH, Eckstein HH, Faggioli G. et al. Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement. J Stroke Cerebrovasc Dis 2021; 31: 106182
• 34 Nedelmann M, Stolz E, Gerriets T, Baumgartner RW, Malferrari G, Seidel G, Kaps M. Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke. Stroke 2009; 40: 3238-3244
• 35 Gerriets T, Goertler M, Stolz E, Postert T, Sliwka U, Schlachetzki F, Seidel G, Weber S, Kaps M. Feasibility and validity of transcranial duplex sonography in patients with acute stroke. J Neurol Neurosurg Psychiatry 2002; 73: 17-20
• 36 Postert T, Braun B, Meves S, Koster O, Przuntek H, Weber S, Buttner T. Contrast-enhanced transcranial color-coded sonography in acute hemispheric brain infarction. Stroke 1999; 30: 1819-1826
• 37 Van der Giessen H, Wilson LC, Coffey S, Whalley GA. Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography. Australas J Ultrasound Med 2020; 23: 210-219
• 38 Kohrmann M, Schellinger PD, Tsivgoulis G, Steiner T. Patent Foramen Ovale: Story Closed?. J Stroke 2019; 21: 23-30
• 39 https://dgn.org/leitlinien/ll-030-142-kryptogener-schlaganfall-und-offenes-foramen-ovale-2018
• 40 Wilfling S, Kilic M, Tsoneva B, Freyer M, Olmes D, Wendl C, Linker RA, Schlachetzki F. Recurrent vertebrobasilar strokes and transient‑ischemic attacks with challenging workup. Brain Circulation. 2022 in press
• 41 Safouris A, Kargiotis O, Psychogios K, Kalyvas P, Ikonomidis I, Drakopoulou M, Toutouzas K, Tsivgoulis G. A Narrative and Critical Review of Randomized-Controlled Clinical Trials on Patent Foramen Ovale Closure for Reducing the Risk of Stroke Recurrence. Front Neurol 2020; 11: 434
• 42 Wunderlich MT, Goertler M, Postert T, Schmitt E, Seidel G, Gahn G, Samii C, Stolz E. Recanalization after intravenous thrombolysis: does a recanalization time window exist?. Neurology 2007; 68: 1364-1368
• 43 Kneihsl M, Niederkorn K, Deutschmann H, Enzinger C, Poltrum B, Horner S, Thaler D, Kraner J, Fandler S, Colonna I. et al. Abnormal Blood Flow on Transcranial Duplex Sonography Predicts Poor Outcome After Stroke Thrombectomy. Stroke 2018; 49: 2780-2782
• 44 Baracchini C, Farina F, Palmieri A, Kulyk C, Pieroni A, Viaro F, Cester G, Causin F, Manara R. Early hemodynamic predictors of good outcome and reperfusion injury after endovascular treatment. Neurology 2019; 92: e2774-e2783
• 45 Perren F, Kargiotis O, Pignat JM, Pereira VM. Hemodynamic Changes May Indicate Vessel Wall Injury After Stent Retrieval Thrombectomy for Acute Stroke. J Neuroimaging 2018; 28: 412-415
• 46 van Mook WN, Rennenberg RJ, Schurink GW, van Oostenbrugge RJ, Mess WH, Hofman PA, de Leeuw PW. Cerebral hyperperfusion syndrome. Lancet Neurol 2005; 4: 877-888
• 47 Haidegger M, Kneihsl M, Niederkorn K, Deutschmann H, Mangge H, Vetta C, Augustin M, Wunsch G, Fandler-Hofler S, Horner S. et al. Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis. Sci Rep 2021; 11: 15599
• 48 Meyer M, Juenemann M, Braun T, Schirotzek I, Tanislav C, Engelhard K, Schramm P. Impaired Cerebrovascular Autoregulation in Large Vessel Occlusive Stroke after Successful Mechanical Thrombectomy: A Prospective Cohort Study. J Stroke Cerebrovasc Dis 2020; 29: 104596
• 49 Kneihsl M, Niederkorn K, Deutschmann H, Enzinger C, Poltrum B, Fischer R, Thaler D, Hermetter C, Wunsch G, Fazekas F. et al. Increased middle cerebral artery mean blood flow velocity index after stroke thrombectomy indicates increased risk for intracranial hemorrhage. J Neurointerv Surg 2018; 10: 882-887
• 50 Aoki J, Raber LN, Katzan IL, Hussain MS, Hui FK, Uchino K. Post-intervention TCD examination may be useful to predict outcome in acute ischemic stroke patients with successful intra-arterial intervention. J Neurol Sci 2013; 334: 26-29
• 51 Chen H, Su Y, He Y, Zhang Y, Sun Y, Fan L, Liu G, Chen Z. Controlling Blood Pressure Under Transcranial Doppler Guidance after Endovascular Treatment in Patients with Acute Ischemic Stroke. Cerebrovasc Dis 2020; 49: 160-169
• 52 Alexandrov AV, Molina CA, Grotta JC, Garami Z, Ford SR, Alvarez-Sabin J, Montaner J, Saqqur M, Demchuk AM, Moye LA. et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004; 351: 2170-2178
• 53 Eggers J, Konig IR, Koch B, Handler G, Seidel G. Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: results from a randomized study. Stroke 2008; 39: 1470-1475
• 54 Alexandrov AV, Kohrmann M, Soinne L, Tsivgoulis G, Barreto AD, Demchuk AM, Sharma VK, Mikulik R, Muir KW, Brandt G. et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurol 2019; 18: 338-347
• 55 Nedelmann M, Ritschel N, Doenges S, Langheinrich AC, Acker T, Reuter P, Yeniguen M, Pukropski J, Kaps M, Mueller C. et al. Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion. J Cereb Blood Flow Metab 2010; 30: 1712-1720
• 56 Meairs S, Culp W. Microbubbles for thrombolysis of acute ischemic stroke. Cerebrovasc Dis 2009; 27: 55-65
• 57 Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, Arenillas JF, Huertas R, Purroy F, Delgado P. et al. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 2006; 37: 425-429
• 58 Nedelmann M, Gerriets T, Kaps M. [Therapeutic ultrasound of acute cerebral artery occlusion]. Nervenarzt 2008; 79: 1399-1400 1402-1396
• 59 Molina CA, Barreto AD, Tsivgoulis G, Sierzenski P, Malkoff MD, Rubiera M, Gonzales N, Mikulik R, Pate G, Ostrem J. et al. Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial. Ann Neurol 2009; 66: 28-38
• 60 de Rooij NK, Linn FH, van der Plas JA, Algra A, Rinkel GJ. Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends. J Neurol Neurosurg Psychiatry 2007; 78: 1365-1372
• 61 White PM, Wardlaw JM, Teasdale E, Sloss S, Cannon J, Easton V. Power transcranial Doppler ultrasound in the detection of intracranial aneurysms. Stroke 2001; 32: 1291-1297
• 62 Griewing B, Motsch L, Piek J, Schminke U, Brassel F, Kessler C. Transcranial power mode Doppler duplex sonography of intracranial aneurysms. J Neuroimaging 1998; 8: 155-158
• 63 Turner CL, Higgins JN, Gholkar A, Mendelow AD, Molyneux AJ, Kerr RS, Chawda S, Kirkpatrick PJ. Intracranial aneurysms treated with endovascular coils: detection of recurrences using unenhanced and contrast-enhanced transcranial color-coded duplex sonography. Stroke 2005; 36: 2654-2659
• 64 Wendl CM, Eiglsperger J, Schuierer G, Jung EM. Evaluating post-interventional occlusion grades of cerebral aneurysms with transcranial contrast-enhanced ultrasound (CEUS) using a matrix probe. Ultraschall Med 2015; 36: 168-173
• 65 Weyer GW, Nolan CP, Macdonald RL. Evidence-based cerebral vasospasm management. Neurosurg Focus 2006; 21: E8
• 66 Aaslid R, Huber P, Nornes H. Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg 1984; 60: 37-41
• 67 Grosset DG, Straiton J, McDonald I, Cockburn M, Bullock R. Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage. J Neurosurg 1993; 78: 183-187
• 68 Krejza J, Mariak Z, Walecki J. Usefulness of transcranial color-coded sonography in the diagnosis of cerebral vasospasm. Stroke 1999; 30: 2240-2241
• 69 Aaslid R. Transcranial Doppler assessment of cerebral vasospasm. Eur J Ultrasound 2002; 16: 3-10
• 70 Ionita CC, Graffagnino C, Alexander MJ, Zaidat OO. The value of CT angiography and transcranial doppler sonography in triaging suspected cerebral vasospasm in SAH prior to endovascular therapy. Neurocrit Care 2008; 9: 8-12
• 71 Romano JG, Rabinstein AA, Arheart KL, Nathan S, Campo-Bustillo I, Koch S, Forteza AM. Microemboli in aneurysmal subarachnoid hemorrhage. J Neuroimaging 2008; 18: 396-401
• 72 Markus HS, Tegeler CH. Experimental aspects of high-intensity transient signals in the detection of emboli. J Clin Ultrasound 1995; 23: 81-87
• 73 Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M, Markus HS, Russell D, Siebler M. Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection. Stroke 1998; 29: 725-729
• 74 Dittrich R, Ringelstein EB. Occurrence and clinical impact of microembolic signals during or after cardiosurgical procedures. Stroke 2008; 39: 503-511
• 75 Ritter MA, Dittrich R, Thoenissen N, Ringelstein EB, Nabavi DG. Prevalence and prognostic impact of microembolic signals in arterial sources of embolism. A systematic review of the literature. J Neurol 2008; 255: 953-961
• 76 Markus HS, Droste DW, Kaps M, Larrue V, Lees KR, Siebler M, Ringelstein EB. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation 2005; 111: 2233-2240
• 77 Spence JD, Coates V, Li H, Tamayo A, Munoz C, Hackam DG, DiCicco M, DesRoches J, Bogiatzi C, Klein J. et al. Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis. Arch Neurol 2010; 67: 180-186
• 78 Markus HS, King A, Shipley M, Topakian R, Cullinane M, Reihill S, Bornstein NM, Schaafsma A. Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study. Lancet Neurol 2010; 9: 663-671
• 79 Huang G, Johnson LL, Peacock JE, Tegeler C, Davis K, Sarwal A. Transcranial Doppler Emboli Monitoring for Infective Endocarditis. J Neuroimaging 2020; 30: 486-492
• 80 Roldan CA, Sibbitt WL, Qualls CR, Jung RE, Greene ER, Gasparovic CM, Hayek RA, Charlton GA, Crookston K. Libman-Sacks endocarditis and embolic cerebrovascular disease. JACC Cardiovasc Imaging 2013; 6: 973-983
• 81 Wong KS, Chen C, Fu J, Chang HM, Suwanwela NC, Huang YN, Han Z, Tan KS, Ratanakorn D, Chollate P. et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. Lancet Neurol 2010; 9: 489-497
• 82 Gerriets T, Stolz E, Konig S, Babacan S, Fiss I, Jauss M, Kaps M. Sonographic monitoring of midline shift in space-occupying stroke: an early outcome predictor. Stroke 2001; 32: 442-447
• 83 Seidel G, Kaps M, Gerriets T, Hutzelmann A. Evaluation of the ventricular system in adults by transcranial duplex sonography. J Neuroimaging 1995; 5: 105-108
• 84 Becker G, Bogdahn U, Strassburg HM, Lindner A, Hassel W, Meixensberger J, Hofmann E. Identification of ventricular enlargement and estimation of intracranial pressure by transcranial color-coded real-time sonography. J Neuroimaging 1994; 4: 17-22
• 85 Waydhas C. Intrahospital transport of critically ill patients. Crit Care 1999; 3: R83-R89
• 86 Bauerle J, Nedelmann M. Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension. J Neurol. 2011
• 87 Seidel G, Kaps M, Dorndorf W. Transcranial color-coded duplex sonography of intracerebral hematomas in adults. Stroke 1993; 24: 1519-1527
• 88 Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ. et al. Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 2011; 196: 221-237
• 89 Bauerle J, Lochner P, Kaps M, Nedelmann M. Intra- and interobsever reliability of sonographic assessment of the optic nerve sheath diameter in healthy adults. J Neuroimaging 2012; 22: 42-45
• 90 Geeraerts T, Newcombe VF, Coles JP, Abate MG, Perkes IE, Hutchinson PJ, Outtrim JG, Chatfield DA, Menon DK. Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure. Crit Care 2008; 12: R114
• 91 Schroeder C, Katsanos AH, Richter D, Tsivgoulis G, Gold R, Krogias C. Quantification of Optic Nerve and Sheath Diameter by Transorbital Sonography: A Systematic Review and Metanalysis. J Neuroimaging 2020; 30: 165-174
• 92 Ertl M, Knuppel C, Veitweber M, Wagner A, Pfister K, Wendl C, Baldaranov D, Beck J, Linker RA, Schlachetzki F. Normal Age- and Sex-Related Values of the Optic Nerve Sheath Diameter and Its Dependency on Position and Positive End-Expiratory Pressure. Ultrasound Med Biol 2020; 46: 3279-3285
• 93 Bauerle J, Nedelmann M. Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension. J Neurol 2011; 258: 2014-2019
• 94 Geeraerts T, Launey Y, Martin L, Pottecher J, Vigue B, Duranteau J, Benhamou D. Ultrasonography of the optic nerve sheath may be useful for detecting raised intracranial pressure after severe brain injury. Intensive Care Med 2007; 33: 1704-1711
• 95 Moretti R, Pizzi B. Optic nerve ultrasound for detection of intracranial hypertension in intracranial hemorrhage patients: confirmation of previous findings in a different patient population. J Neurosurg Anesthesiol 2009; 21: 16-20
• 96 Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B. Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis. Intensive Care Med 2011; 37: 1059-1068
• 97 Kiphuth IC, Huttner HB, Struffert T, Schwab S, Kohrmann M. Sonographic monitoring of ventricle enlargement in posthemorrhagic hydrocephalus. Neurology 2011; 76: 858-862
• 98 Moskowitz SI, Davros WJ, Kelly ME, Fiorella D, Rasmussen PA, Masaryk TJ. Cumulative radiation dose during hospitalization for aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol 2010; 31: 1377-1382
• 99 Markus HS, Harrison MJ. Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke 1992; 23: 668-673
• 100 Piepgras A, Schmiedek P, Leinsinger G, Haberl RL, Kirsch CM, Einhaupl KM. A simple test to assess cerebrovascular reserve capacity using transcranial Doppler sonography and acetazolamide. Stroke 1990; 21: 1306-1311
• 101 Claassen JA, Meel-van den Abeelen AS, Simpson DM, Panerai RB. international Cerebral Autoregulation Research N: Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network. J Cereb Blood Flow Metab 2016; 36: 665-680
• 102 Crippa IA, Subira C, Vincent JL, Fernandez RF, Hernandez SC, Cavicchi FZ, Creteur J, Taccone FS. Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis. Crit Care 2018; 22: 327
• 103 Lavinio A, Schmidt EA, Haubrich C, Smielewski P, Pickard JD, Czosnyka M. Noninvasive evaluation of dynamic cerebrovascular autoregulation using Finapres plethysmograph and transcranial Doppler. Stroke 2007; 38: 402-404
• 104 Minhas JS, Panerai RB, Ghaly G, Divall P, Robinson TG. Cerebral autoregulation in hemorrhagic stroke: A systematic review and meta-analysis of transcranial Doppler ultrasonography studies. J Clin Ultrasound 2019; 47: 14-21
• 105 Tian G, Ji Z, Lin Z, Pan S, Yin J. Cerebral autoregulation is heterogeneous in different stroke mechanism of ischemic stroke caused by intracranial atherosclerotic stenosis. Brain Behav 2021; 11: e01907
• 106 Cardim D, Robba C, Bohdanowicz M, Donnelly J, Cabella B, Liu X, Cabeleira M, Smielewski P, Schmidt B, Czosnyka M. Non-invasive Monitoring of Intracranial Pressure Using Transcranial Doppler Ultrasonography: Is It Possible?. Neurocrit Care 2016; 25: 473-491
• 107 Robba C, Pozzebon S, Moro B, Vincent JL, Creteur J, Taccone FS. Multimodal non-invasive assessment of intracranial hypertension: an observational study. Crit Care 2020; 24: 379
• 108 Walter U, Schreiber SJ, Kaps M. Doppler and Duplex Sonography for the Diagnosis of the Irreversible Cessation of Brain Function (“Brain Death”): Current Guidelines in Germany and Neighboring Countries. Ultraschall Med 2016; 37: 558-578
• 109 Brandt SA, Angstwurm H. Working Group “The relevance of irreversible loss of brain function as a reliable sign of death” of the Scientific Advisory Board within the German Medical A The Relevance of Irreversible Loss of Brain Function as a Reliable Sign of Death. Dtsch Arztebl Int 2018; 115: 675-681
• 110 Monteiro LM, Bollen CW, van Huffelen AC, Ackerstaff RG, Jansen NJ, van Vught AJ. Transcranial Doppler ultrasonography to confirm brain death: a meta-analysis. Intensive Care Med 2006; 32: 1937-1944
• 111 Chang JJ, Tsivgoulis G, Katsanos AH, Malkoff MD, Alexandrov AV. Diagnostic Accuracy of Transcranial Doppler for Brain Death Confirmation: Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol 2016; 37: 408-414
• 112 Farina F, Vosko MR, Baracchini C, Ermani M, Sommer P, Greisenegger S, Laubichler P, Struhal W, Kellermair L, Ransmayr G. et al. Ultrasound Examination of the Pupil - A New Tool for the Neuro-Ophthalmological Assessment. Ultraschall Med 2021; 42: 84-91
• 113 S3-Leitlinie zur Diagnostik, Therapie und Nachsorge der extracraniellen Carotisstenose (03.Februar 2020) Im Internet: https:// www.awmf.org/uploads/tx_szleitlinien/004-028l_extracranielle- Carotisstenose-Diagnostik-Therapie-Nachsorge_2020-02_03.pdf
• 114 Aaslid, R. Transcranial Doppler assessment of cerebral vasospasm. Eur J Ultrasound 16: 3–10
• 115 Sloan, MA, Burch CM, Wozniak MA, Rothman MI, Rigamonti D, Permutt T, Numagchi Y. Transcranial Doppler detection of cerebral vasospasm following subarachnoid hemorrhage. Stroke 1994; 25: 2187–2197