Carbapenemase-bildende Enterobakterien (CBE)

Carbapenemasen sind bakterielle Enzyme, die Carbapeneme und andere Beta-Laktam-Antibiotika inaktivieren. Viele gramnegative Spezies, darunter vor allem Enterobakterien, können Carbapenemasen bilden, was die therapeutischen Möglichkeiten im Infektionsfall stark einschränkt.

Publication History

Article published online:
11 July 2022

• Literatur

• 1 European Centre for Disease Prevention and Control (ECDC) Surveillance Atlas Antimicrobial Resistance. Im Internet (Stand: 04.05.2022):. https://www.ecdc.europa.eu/en/antimicrobial-resistance/surveillance-and-disease-data/data-ecdc
• 2 Pfennigwerth N, Schauer J. Bericht des Nationalen Referenzzentrums für gramnegative Krankenhauserreger – Zeitraum 1. Januar 2020 bis 31. Dezember 2020. Epid Bull 2021; 36: 4-11
• 3 Lübbert C, Lippmann N, Busch T. et al. Long-term carriage of Klebsiella pneumoniae carbapenemase-2-producing K pneumoniae after a large single-center outbreak in Germany. Am J Infect Control 2014; 42: 376-380 DOI: 10.1016/j.ajic.2013.12.001. (PMID: 24679563)
• 4 Haller S, Kramer R, Becker K. et al. Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019. Euro Surveill 2019; 24: 1900734 DOI: 10.2807/1560-7917.ES.2019.24.50.1900734. (PMID: 31847948)
• 5 Kremer K, Kramer R, Neumann B. et al. Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020. Euro Surveill 2020; 25: 2000923 DOI: 10.2807/1560-7917.ES.2020.25.25.2000923. (PMID: 32613940)
• 6 Müller H, Sib E, Gajdiss M. et al. Dissemination of multi-resistant Gram-negative bacteria into German wastewater and surface waters. FEMS Microbiol Ecol 2018; 94 (05) DOI: 10.1093/femsec/fiy057. (PMID: 29659796)
• 7 Westerholt M, Hasman H, Hansen DS. et al. Screening patients at admission to Copenhagen hospitals for carriage of resistant bacteria after contact with healthcare systems abroad, 2016–2019. Int J Antimicrob Agents 2021; 58: 106452 DOI: 10.1016/j.ijantimicag.2021.106452. (PMID: 34648944)
• 8 Kajova M, Khawaja T, Kantele A. European hospitals as source of multidrug-resistant bacteria: Analysis of travellers screened in Finland after hospitalization abroad. J Travel Med 2022; taac022 DOI: 10.1093/jtm/taac022.
• 9 Robert Koch-Institut. Epid Bull 2014; 47: 453–59. Im Internet (Stand: 04.05.2022):. https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2014/Ausgaben/47_14.pdf
• 10 Weber RE, Pietsch M, Frühauf A. et al. IS26-Mediated Transfer of bla NDM-1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital. Front Microbiol 2019; 10: 2817 DOI: 10.3389/fmicb.2019.02817. (PMID: 31921015)
• 11 Schweizer C, Bischoff P, Bender J. et al. Plasmid-Mediated Transmission of KPC-2 Carbapenemase in Enterobacteriaceae in Critically Ill Patients. Front Microbiol 2019; 10: 276 DOI: 10.3389/fmicb.2019.00276. (PMID: 30837980)
• 12 Naas T, Oueslati S, Bonnin RA. et al. Beta-Lactamase DataBase (BLDB) – Structure and Function. J Enzyme Inhib Med Chem 2017; 32: 917-919 DOI: 10.1080/14756366.2017.1344235. (PMID: 28719998)
• 13 Robert Koch-Institut. Epid Bull 2019; 9: 81–83. Im Internet (Stand: 04.05.2022):. https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2019/Ausgaben/09_19.pdf?__blob=publicationFile
• 14 Nationales Antibiotika-Sensitivitätstest-Komitee (NAK). Empfehlungen zur Detektion von Carbapenemasen bei Enterobakterien. Im Internet (Stand: 04.05.2022):. https://www.nak-deutschland.org/nak-dokumente/detektion-von-resistenzmechanismen/dokumente.html
• 15 RKI, KRINKO. Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut (RKI) zu Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsblatt 2012; 55: 1311-1354 https://www.rki.de/DE/Content/Infekt/Krankenhaushygiene/Kommission/Downloads/Gramneg_Erreger.html
• 16 Perry JD. A Decade of Development of Chromogenic Culture Media for Clinical Microbiology in an Era of Molecular Diagnostics. Clin Microbiol Rev 2017; 30: 449-479 DOI: 10.1128/CMR.00097-16. (PMID: 28122803)
• 17 Grabein B, Ebenhoch M, Kühnen E. et al. Kalkulierte parenterale Initialtherapie bakterieller Infektionen: Infektionen durch multiresistente gramnegative Stäbchen – ESBL-Bildner, Carbapenemase-bildende Enterobacteriaceae, Carbapenem-resistente Acinetobacter baumannii. GMS Infect Dis 2020; 8: Doc04 DOI: 10.3205/id000048. (PMID: 20200326)
• 18 Tamma PD, Aitken SL, Bonomo RA. et al. Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended- Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa). Clin Infect Dis 2022; ciac268 DOI: 10.1093/cid/ciac268.
• 19 Paul M, Carrara E, Retamar P. et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine. Clin Microbiol Infect 2022; 28: 521-547 DOI: 10.1016/j.cmi.2021.11.025. (PMID: 34923128)