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Synthesis 2022; 54(14): 3239-3248
DOI: 10.1055/a-1794-0685
DOI: 10.1055/a-1794-0685
paper
Halocyclobutanol Dehydration En Route to Halocyclobutenes
This work was supported by the Vysoká Škola Chemicko-technologická v Praze (University of Chemistry and Technology, Prague) (A2_FCHT_2021_074) and the Grantová Agentura České Republiky (Grant Agency of the Czech Republic) (18-12150S).
Abstract
A new method for the preparation of halocyclobutenes is described. The developed process involves the dehydration of halocyclobutanols by using tetrafluoroboric acid–diethyl ether complex in dichloromethane at room temperature. The process allows for high yields of halocyclobutenes to be achieved by using alcohols that do not trigger the formation of isomeric allylic halides.
Key words
elimination - alkenes - Grignard reaction - halohydrins - tetrafluoroboric acid–diethyl ether complexSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1794-0685.
- Supporting Information
Publication History
Received: 05 January 2022
Accepted after revision: 10 March 2022
Accepted Manuscript online:
10 March 2022
Article published online:
02 May 2022
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