Rh(III)-Catalyzed Tandem [4+2] Annulation To Construct Functional Dihydroisoquinolinones

Abstract

A highly efficient Rh(III)-catalyzed tandem [4+2] annulation to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by insertion into an N–O bond as an internal oxidation process has been achieved. A wide range of 1,3-dienes as the coupling partners makes this simple methodology even more useful.

Key words

1,3-dienes - rhodium(III) catalysis - tandem [4+2] annulation - dihydroisoquinolinones - internal oxidant

Publication History

Received: 14 January 2022

Accepted after revision: 03 March 2022

Accepted Manuscript online:
03 March 2022

Article published online:
21 April 2022

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