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Synthesis 2022; 54(10): 2391-2394
DOI: 10.1055/a-1766-2416
DOI: 10.1055/a-1766-2416
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Giving Preparative Thin-Layer Chromatography Some Tender Loving Care
The authors declare no competing financial interest. This study was supported by the Natural Sciences and Engineering Research Council of Canada #2018-06338 (J.F.T.) and the Government of Ontario #ER18-14-114 (J.F.T.; salary for J.J.H.).
Abstract
Preparative thin-layer chromatography (prepTLC) is a commonly used method of purification suitable for small-scale reactions. However, descriptions of the preferred methodology to load, run, and recover samples from prepTLC are non-standard and varied, making it part of the ‘hidden curriculum’ of laboratory techniques. In this article we report on the simple, cost-effective methods we use to load and collect samples from a plate, which enhance the convenience, speed, and precision of this technique.
Key words
laboratory technique - chromatography - separation science - thin-layer chromatography - toolsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1766-2416.
- Video
Publication History
Received: 29 November 2021
Accepted after revision: 08 February 2022
Accepted Manuscript online:
08 February 2022
Article published online:
16 March 2022
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