Subscribe to RSS
DOI: 10.1055/a-1750-9643
Chirurgische Therapie maligner Lungen- und Brustwandtumoren bei Kindern
Surgical Therapy of Malignant Lung and Chest Wall Tumours in Children
Zusammenfassung
Primäre Lungen- und Brustwandtumoren sowie Lungenmetastasen stellen bei Kindern äußerst seltene Erkrankungen dar. Eingebunden in multimodale Therapiekonzepte können thoraxchirurgische Eingriffe bei pädiatrischen onkologischen Erkrankungen dazu beitragen, die Prognose der erkrankten Kinder signifikant zu verbessern. Ziel des Übersichtsartikels ist es, die Indikationsstellung und die aktuellen thoraxchirurgischen Therapieoptionen bei malignen Brustwand- und Lungentumoren darzustellen sowie den aktuellen Stellenwert der pulmonalen Metastasenchirurgie bei Kindern zu beleuchten. Die Arbeit stellt darüber hinaus das Diagnosespektrum und thoraxchirurgische Operationsspektrum im Bereich der onkologischen pädiatrischen Thoraxchirurgie an einem spezialisierten Zentrum in Deutschland dar.
Abstract
Primary lung and chest wall tumours as well as lung metastases are rare diseases in children. As part of multimodal cancer treatment, thoracic surgery can significantly improve survival in children suffering from paediatric solid tumours. The aim of the review article is to summarise the indications and the current surgical treatment options for malignant chest wall and lung tumours as well as to shed light on the current role of pulmonary metastasectomy in children.
Publication History
Received: 08 November 2021
Accepted after revision: 24 January 2022
Article published online:
28 March 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Robert Koch-Institut. Krebs in Deutschland für 2015/2016. Berlin: Robert Koch-Institut; 2019. https://www.krebsdaten.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/kid_2019/krebs_in_deutschland_2019.pdf?__blob=publicationFile
- 2 Pfister SM, Reyes-Múgica M, Chan JKC. et al. A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era. Cancer Discov 2021;
- 3 Harris CJ, Helenowski I, Murphy AJ. et al. Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children with Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study. Ann Surg 2020;
- 4 Bölling T, Braun-Munzinger G, Burdach S. et al. Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe. Klin Padiatr 2015; 227: 108-115
- 5 Gaspar N, Hawkins DS, Dirksen U. et al. Ewing Sarcoma: Current Management and Future Approaches Through Collaboration. J Clin Oncol 2015; 33: 3036-3046
- 6 Basharkhah A, Lackner H, Karastaneva A. et al. Interdisciplinary Radical “En-Bloc” Resection of Ewing Sarcoma of the Chest Wall and Simultaneous Chest Wall Repair Achieves Excellent Long-Term Survival in Children and Adolescents. Front Pediatr 2021; 9: 661025
- 7 Lopez C, Correa A, Vaporciyan A. et al. Outcomes of chest wall resections in pediatric sarcoma patients. J Pediatr Surg 2017; 52: 109-114
- 8 Saltsman JA, Danzer E, Hammond WJ. et al. Survival and Scoliosis Following Resection of Chest Wall Tumors in Children and Adolescents: A Single-center Retrospective Analysis. Ann Surg 2021; 274: e167-e173
- 9 Cohen MC, Kaschula RO. Primary pulmonary tumors in childhood: a review of 31 years’ experience and the literature. Pediatr Pulmonol 1992; 14: 222-232
- 10 Yu DC, Grabowski MJ, Kozakewich HP. et al. Primary lung tumors in children and adolescents: a 90-year experience. J Pediatr Surg 2010; 45: 1090-1095
- 11 Mahajan P, Casanova M, Ferrari A. et al. Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges. Curr Probl Cancer 2021; 45: 100768
- 12 Sparber-Sauer M, Tagarelli A, Seitz G. et al. Children with progressive and relapsed pleuropulmonary blastoma: A European collaborative analysis. Pediatr Blood Cancer 2021; 68: e29268
- 13 Weldon CB, Shamberger RC. Pediatric pulmonary tumors: primary and metastatic. Semin Pediatr Surg 2008; 17: 17-29
- 14 Fuchs J, Seitz G, Handgretinger R. et al. Surgical treatment of lung metastases in patients with embryonal pediatric solid tumors: an update. Semin Pediatr Surg 2012; 21: 79-87
- 15 Croteau NJ, Heaton TE. Pulmonary Metastasectomy in Pediatric Solid Tumors. Children (Basel) 2019; 6: 6
- 16 Scanagatta P, Girelli L. Metastasectomy in pediatric patients: indications, technical tips and outcomes. J Thorac Dis 2017; 9: S1299-s1304
- 17 Kayton ML, Huvos AG, Casher J. et al. Computed tomographic scan of the chest underestimates the number of metastatic lesions in osteosarcoma. J Pediatr Surg 2006; 41: 200-206
- 18 Tobias JD, Lowe S, O’Dell N. et al. Thoracic epidural anaesthesia in infants and children. Can J Anaesth 1993; 40: 879-882