Synthesis 2022; 54(11): 2585-2594
DOI: 10.1055/a-1748-6564
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Addition/Substitution Approach of TsNHCH2SiMe2CH2Cl with Isocyanates or Isothiocyanates To Construct 1,3,5-Diazasilinan-2-ones or 1,3,5-Thiazasilinan-2-imines

Yi Li
,
Tianbao Hu
,
Lu Gao
,
Zhenlei Song
We are grateful for the financial support from the National Natural Science Foundation of China (21921002, 22171191), the Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China (2020LF2003), and the Science and Technology Department of Sichuan Province (2020YFS0186).


Abstract

TsNHCH2SiMe2CH2Cl has been exploited as a 1,4-dipole synthon for the synthesis of 1,3,5-diazasilinan-2-ones by a sequential N-addition/N-substitution process with isocyanates, or for the synthesis of 1,3,5-thiazasilinan-2-imines with isothiocyanates by a sequential N-addition/S-substitution process.

Supporting Information



Publication History

Received: 31 December 2021

Accepted after revision: 24 January 2022

Accepted Manuscript online:
24 January 2022

Article published online:
03 March 2022

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