Subscribe to RSS
DOI: 10.1055/a-1744-0044
Gesund schwanger mit ausgewählten (Mikro-)Nährstoffen
Zusammenfassung
Eine bedarfsgerechte Ernährung ist für den Schwangerschaftsverlauf, die Geburt und die Entwicklung des Kindes von hoher Bedeutung. Bereits vor der Konzeption sollte auf einen adäquaten Versorgungsstatus mit essenziellen Nährstoffen geachtet werden. Der Bedarf an Vitaminen und anderen (Mikro-)Nährstoffen in der Schwangerschaft übersteigt bei weitem den zusätzlichen Energiebedarf. Als bes. kritische Nährstoffe gelten Folsäure, ω-3-Fettsäuren, Vitamin D, Jod, Selen und Eisen. Während sich die Supplementierung von Eisen oder Jod in der Schwangerschaft und Stillzeit langsam durchsetzt, wird die Bedeutung von einigen Mikronährstoffen wie Folsäure, Vitamin D, Magnesium oder ω-3-Fettsäuren für die Entwicklung des Kindes zu wenig beachtet. Nach Bestimmung des Status wird eine Supplementierung in der Schwangerschaft empfohlen.
Schlüsselwörter
Schwangerschaft - (Mikro-)Nährstoffe - Vitamine - Mineralstoffe - Mehrbedarf - Folsäure - Folat - ω-3-Fettsäuren - Vitamin D - Magnesium - SelenPublication History
Article published online:
28 March 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Botto LD, Mullinare J, Erickson JD. Occurrence of congenital heart defects in relation to maternal mulitivitamin use. Am J Epidemiol 2000; 151: 878-884
- 2 Botto LD, Lynberg MC, Erickson JD. et al. Congenital heart defects, maternal febrile illness, and multivitamin use: a population-based study. Epidemiology 2001; 12: 485-490
- 3 Goh YI, Bollano E, Einarson TR. et al. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can 2006; 28: 680-689
- 4 Qu Y, Lin S, Zhuang J. et al. First-Trimester Maternal Folic Acid Supplementation Reduced Risks of Severe and Most Congenital Heart Diseases in Offspring: A Large Case-Control Study. J Am Heart Assoc 2020; 9: e015652
- 5 Pouchieu C, Levy R, Faure C. et al. Socioeconomic, lifestyle and dietary factors associated with dietary supplement use during pregnancy. PLoS One 2013; 8: e70733
- 6 von der Porten AE, Gregory JF, Toth JP. et al. In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid. J Nutr 1992; 122: 1293-1299
- 7 Hursthouse NA, Gray AR, Miller JC. et al. Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day. Nutrients 2011; 3: 49-62
- 8 Sun F, Qian W, Zhang C. et al. Correlation of Maternal Serum Homocysteine in the First Trimester with Development of Gestational Hypertension and Preeclampsia. Med Sci Monit 2017; 23: 5396-5401
- 9 Obeid R, Pietrzik K, Oakley GP. et al. Preventable spina bifda and anencephaly in Europe. Birth Defects Res A Clin Mol Teratol 2015; 103: 763-771
- 10 World Health Organization (2015). Guidelines: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects. World Health Organization, Geneva/Switzerland, 2015 https://apps.who.int/iris/handle/10665/161988(Stand: 11.01.2022)
- 11 Obeid R, Schön C, Wilhelm M. et al. The effectiveness of daily supplementation with 400 or 800 µg/day folate in reaching protective red blood folate concentrations in non-pregnant women: a randomized trial. Eur J Nutr 2018; 57: 1771-1780
- 12 Laanpere M. et al. Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. Nutr Rev 2010; 68: 99-113
- 13 Yu Y, Jia C, Shi Q. et al. Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects. Medicine (Baltimore) 2019; 98: e13998
- 14 Gellert S, Schuchardt JP, Hahn A. Higher omega-3 index and DHA status in pregnant women compared to lactating women – Results from a German nation-wide cross-sectional study. P L E F A 2016; 109: 22-28
- 15 von Schacky C. Omega-3 Fatty Acids in Pregnancy – The Case for a Target Omega-3 Index. Nutrients 2020; 12: 898 DOI: 10.3390/nu12040898.
- 16 Hibbeln JR, Davis JD, Steer C. et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 2007; 369: 578-585
- 17 Ramsden CE. Breathing Easier with Fish Oil – A New Approach to Preventing Asthma?. N Engl J Med 2016; 375: 2596-2598 DOI: 10.1056/NEJMe1611723.
- 18 Miles EA, Calder PC. Can Early Omega-3 Fatty Acid Exposure Reduce Risk of Childhood Allergic Disease?. Nutrients 2017; 9: 784
- 19 Middleton P, Gomersall JC, Gould JF. et al. Omega-3 fatty acid addition during pregnancy. Cochrane Database Sys Rev 2018; 11 DOI: 10.1002/14651858.
- 20 Falsig AML, Gleerup CS, Knudsen UB. The influence of omega-3 fatty acids on semen quality markers: a systematic PRISMA review. Andrology 2019; 7: 794-803
- 21 Coletta JM, Bell SJ, Roman AS. Omega-3 Fatty Acids and Pregnancy. Rev Obstet Gynecol 2010; 3: 163-171
- 22 Childs CE, Romijn T, Enke U. et al. Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. PLEFA 2010; 83: 179-184
- 23 Gutierrez S, Svahn SL, Johansson ME. Effects of Omega-3 Fatty Acids on Immune Cells. Int J Mol Sci 2019; 20: 5028
- 24 Gröber U. Omega 3: Gesünder leben mit den essentiellen Fettsäuren. München: Südwest; 2021
- 25 Gröber U, Holick MF. Vitamin D – die Heilkraft des Sonnenvitamins. 4., aktual. u. erw. Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2020
- 26 Spätling L, Classen HG, Kisters K. et al. Magnesiumsupplementation in der Schwangerschaft. Frauenarzt 2015; 56: 892-897
- 27 Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients 2015; 7: 8199-8226
- 28 Gröber U. Magnesium and Drugs. Int J Mol Sci 2019; 20: 2094
- 29 Jones GD, Droz B, Greve P. et al. Selenium deficiency risk predicted to increase under future climate change. Proc Natl Acad Sci USA 2017; 114: 2848-2853
- 30 Vanderlelie J, Perkins AVA. Selenium and preeclampsia: A global perspective. Pregnancy Hypertens 2011; 1: 213-224
- 31 Skröder HM, Hamadani JD, Tofail F. et al. Selenium status in pregnancy influences children’s cognitive function at 1.5 years of age. Clin Nutr 2015; 34: 923-930
- 32 Negro R, Greco G, Mangieri T. et al. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab 2007; 92: 1263-1268
- 33 Mantovani G, Isidori AM, Moretti C. et al. Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial. Endocrine 2019; 66: 542-550
- 34 Schomburg L. Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19 – A Preventable Trigger for Autoimmune Disease. Int J Mol Sci 2021; 22: 8532