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Drug Res (Stuttg) 2022; 72(04): 189-196
DOI: 10.1055/a-1735-2887
Original Article

Decipher the inhibitory potential of phytocompounds from Leptadenia reticulata on dopamine D2 receptor to enhance prolactin secretion

Roshan Kumar Sharma
1   KLE Academy of Higher Education and Research, Dr. Prabhakar Kore Basic Science Research Center, Belagavi, India
,
Sunil S Jalalpure
2   KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi, India
,
Mahendra Kumar Chouhan
1   KLE Academy of Higher Education and Research, Dr. Prabhakar Kore Basic Science Research Center, Belagavi, India
3   Department of Pharmacology, Maharishi Arvind Institute of Pharmacy (MAIP), Jaipur, India
,
Sanjay Deshpande
4   Department of Biotechnology, KLE Technological University, Hubballi, India
,
Rabinarayan Acharya
5   Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
,
Satisha Hegde 
1   KLE Academy of Higher Education and Research, Dr. Prabhakar Kore Basic Science Research Center, Belagavi, India
6   Department of Microbiology, Belagavi Institute of Medical Sciences, Belagavi, India
› Author Affiliations Funding The study was funded by Department of Biotechnology, Govt. of India (Grant Number: BT/PR26908/TRM/120/177/2017)
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Abstract

Dopamine is secreted by the hypothalamus, which inhibits the proliferation and effectiveness of lactotroph cells that release prolactin via dopamine D2 receptor (D2R). D2R activation inhibits lactotroph cell prolactin synthesis and regulates prolactin gene expression. Although, commercial medications are available for hypogalactia and agalactia, various plant sources significantly alleviate these problems. Leptadenia reticulata (Jivanti) is one of the important medicinal plants often consumed by nursing mothers to improve breast milk production. However, mechanism and chemical constituents involved in the inhibition of D2R by Jivanti is unclear. Therefore, in this study the phytocompounds reported from Jivanti were used for in-silico analysis to predict D2R inhibitory potential. The binding affinity value of campesterol and β-sitosterol (− 10.1 and −10.0 kcal/mol) with D2R has high revealed by molecular docking and stable interaction reveled by molecular dynamics simulation. Thus, these lead compounds could exert more D2R inhibitory activity resulting into prolactin release, which may lead to an increase in breast milk production. Although all selected compounds had fine permeation, non-toxic, and non-carcinogenic characteristics predicted by ADMET, campesterol had good solubility, absorption characteristics compared to other. Therefore, Jivanti, which is traditionally known medicinal plant, could be explored as a medication candidate to boost breast milk production.

Key words

Jivanti - Dopamine D2 Receptor - Molecular docking - Prolactin


Publication History

Received: 10 October 2021

Accepted: 27 December 2021

Article published online:
17 February 2022

© 2022. Thieme. All rights reserved.

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