Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters

Abstract

An efficient visible-light-mediated tandem reaction of acryl­oylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters has been developed. The reaction proceeds via radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.

Key words

acryloylbenzamides - isoquinolinediones - addition/cyclization reaction - visible light - photocatalysis

Publikationsverlauf

Eingereicht: 10. Dezember 2021

Angenommen nach Revision: 10. Januar 2022

Accepted Manuscript online:
10. Januar 2022

Artikel online veröffentlicht:
14. März 2022

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