Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides

Abstract

The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.

Key words

carboxylic amides - hydrogenation - imidoyl chlorides - frustrated Lewis pairs - tertiary amines - secondary amines

Publikationsverlauf

Eingereicht: 03. September 2021

Angenommen nach Revision: 28. Oktober 2021

Accepted Manuscript online:
28. Oktober 2021

Artikel online veröffentlicht:
04. Januar 2022

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