Synthesis 2022; 54(06): 1661-1669
DOI: 10.1055/a-1671-6602
paper

A Concise Copper-Catalyzed Oxytrifluoromethylation of Allyl Alcohols

Longhui Chen
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
,
Zequn Yang
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
,
Qi Sun
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
,
Minjie Guo
b   Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China
,
Xintong Feng
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
,
Xiangyang Tang
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
,
Guangwei Wang
a   Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. of China
› Author Affiliations
We are grateful for the financial support from the Natural Science Foundation of Tianjin (19JCYBJC20200) and Tianjin University for support of this research.


In deep memory of Dr. Ei-ichi Negishi.

Abstract

An efficient oxytrifluoromethylation of 1-aryl-substituted allyl alcohols has been developed using Togni’s reagent II as a trifluoromethylation reagent and copper(I) chloride as a catalyst. This reaction proceeded through a one-pot process of trifluoromethylation followed by nucleophilic attack of the vicinal hydroxyl group. This strategy features good diastereoselectivity and broad substrate scope, which provides a facile access to various 2-aryl-3-(2,2,2-trifluoroethyl)oxiranes.

Supporting Information



Publication History

Received: 18 September 2021

Accepted after revision: 18 October 2021

Accepted Manuscript online:
18 October 2021

Article published online:
30 November 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany