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Exp Clin Endocrinol Diabetes 2022; 130(08): 532-538
DOI: 10.1055/a-1666-0431
Article

Shear Wave Elastography Reveals a High Prevalence of NAFLD-related Fibrosis even in Type 1 Diabetes

Gesine Meyer‡
1   Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany
,
Nina Dauth‡
1   Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany
,
Matthias Grimm
1   Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany
,
Eva Herrmann
2   Institute of Biostatistics and Mathematic Modelling, Goethe-University, Frankfurt, Germany
,
Joerg Bojunga
1   Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany
,
Mireen Friedrich-Rust
1   Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany
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Abstract

Background The association between type 2 diabetes mellitus (T2DM) and advanced stages of non-alcoholic fatty liver disease is well known. Some studies indicate a relevant prevalence also in type 1 diabetes mellitus (T1DM), but so far there is only limited data.

Objective To determine the prevalence of non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis in individuals with T1DM and compare to those with type 2 diabetes.

Methods Diabetic patients from a single diabetes care centre were screened for liver fibrosis by sonographic shear wave elastography (SWE). In addition, all patients received laboratory evaluation including non-alcoholic fatty liver fibrosis score and Fibrosis-4 Index.

Results Three hundred and forty patients were included in the study, of these, 310 received SWE. Overall 254 patients (93 with type 1 and 161 with type 2 diabetes) had reliable measurements and were included in the final analysis. In patients with type 1 diabetes, the prevalence of NAFLD-related liver fibrosis was 16–21%, depending on the method of detection. Significant liver fibrosis was observed in 30–46% of patients with type 2 diabetes.

Conclusions Our data revealed an unexpectedly high prevalence of NAFLD-related liver fibrosis in patients with type 1 diabetes. To our knowledge, this is one of the first studies using SWE to diagnose advanced NAFLD in type 1 diabetes in a non-preselected cohort. Considering the findings of our study, regular screening for hepatic complications must be recommended for all diabetic patients, even for those with type 1 diabetes.

Key words

Diabetes mellitus, type 1 - diabetes mellitus, type 2 - elasticity imaging techniques - non-alcoholic fatty liver disease


Publication History

Received: 22 July 2021
Received: 14 September 2021

Accepted: 06 October 2021

Article published online:
16 November 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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