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Synthesis 2022; 54(03): 779-787
DOI: 10.1055/a-1588-0974
DOI: 10.1055/a-1588-0974
paper
Ruthenium-Catalyzed Alkylation of Cyclopropanols with Sulfoxonium Ylides via C–C Bond Cleavage: Formation of Diverse 1,5-Diketones
This work was supported by the National Natural Science Foundation of China (81573286 and 81373259).
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Abstract
A novel ruthenium-catalyzed alkylation of cyclopropanols with sulfoxonium ylides has been developed that affords diverse 1,5-diketones with good efficiency and broad substrate scope. To illustrate the synthetic applications of the obtained 1,5-diketones, aldol and cyclization reactions have been investigated. Preliminary mechanistic studies suggest that this process involves a sequential C–C activation and carbene migratory insertion.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1588-0974
- Supporting Information
Publication History
Received: 08 July 2021
Accepted after revision: 16 August 2021
Accepted Manuscript online:
16 August 2021
Article published online:
18 October 2021
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