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DOI: 10.1055/a-1580-9688
One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent
This project was supported by the National Natural Science Foundation of China (Nos. 11765002, 21966003) and the Science and Technology Project of Jiangxi (No. 20192BBH80012).
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Abstract
4H-Pyrano[3,2-c]coumarin derivatives are an important class of pharmaceutical compounds that are expensive to prepare by previously reported methods. An efficient and green method was developed to obtain these derivatives using the deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. An aromatic aldehyde, 4-hydroxycoumarin, and cyanoacetate were used as the substrates. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.
Key words
deep eutectic solvent - dihydropyrano[3,2-c]chromene - zinc chloride - acetamide - 4-hydroxycoumarinSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1580-9688.
- Supporting Information
Publikationsverlauf
Eingereicht: 26. Juni 2021
Angenommen nach Revision: 09. August 2021
Accepted Manuscript online:
09. August 2021
Artikel online veröffentlicht:
13. Oktober 2021
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