Neuromyelitis-optica-Spektrum-Erkrankungen – alte und neue Entwicklungen

Die Entwicklung der letzten 15 Jahre hat die Diagnostik und Therapie der Neuromyelitis-optica-Spektrum-Erkrankungen (NMOSD) maßgeblich geprägt – von der Entdeckung der Aquaporin-4-Antikörper über die Differenzierung der diagnostischen Kriterien bis zur kürzlichen Zulassung von Eculizumab und Satralizumab als erste verlaufsmodifizierende Therapien. Dieser Artikel soll einen Überblick über die bisherigen Erkenntnisse und zukünftigen Therapiemöglichkeiten vermitteln.

Abstract

The achievements of the last 15 years have essentially shaped the diagnostic methods and therapy of Neuromyelitis optica spectrum disorders (NMOSD): from discovery of aquaporin 4 antibodies and further development of diagnostic criteria the path has led to the approval of eculizumab and satralizumab as first disease modifying treatments in Europe. This article should give an overview on the present insights and future treatment options.

Key words

NMOSD - MS - disease modifying therapie - optic neuritis - AQP4 - MOG

Publication History

Article published online:
19 October 2021

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