Serum Levels of Interleukin-36 Alpha and Interleukin-36 Receptor Antagonist In Behcet’s Syndrome

Abstract

Background Behcet’s syndrome (BS) is a systemic vasculitic disorder. This study aimed to investigate the levels of serum IL-36α and IL-36Ra in patients with BS.

Material and Methods A total of 80 subjects (60 BS patients and 20 healthy controls [HC]) were included.

Results The median IL-36α level was 0.11 ng/ml in the BS group and 0.09 ng/ml in the HC group (p=0.058). The mean IL-36Ra level was 13.62 pg/ml in the BS group and 13.26 pg/ml in the HC group (p=0.348). Serum IL-36Ra levels of the active group were significantly higher (p=0.037). Patients with oral ulcers and central nervous system involvement had higher serum IL36Ra levels. In the BS group, a positive correlation was found between serum IL-36Ra and CRP. In a multivariate analysis, the IL-36Ra level (OR=1.067; 95% CI=1.001–1.137; p=0.045) was independently associated with disease activity.

Conclusion According to these findings, it is not clear whether such a slight difference is clinically significant, but they suggest that the IL-36 cytokine family may play a role in the course of the disease.

Zusammenfassung

Hintergrund Das Behcet-Syndrom (BS) ist eine Form der systemischen Vaskulitiden. Ziel dieser Studie war es, die Serumspiegel von IL-36α und IL36Ra bei Patienten mit BS zu untersuchen.

Material und Methoden Insgesamt 80 Probanden (60 BS-Patienten und 20 gesunde Kontrollpersonen [KP]) wurden in die Studie eingeschlossen.

Ergebnisse Der mittlere IL-36α-Spiegel betrug im BS 0,11 ng/ml und im KP 0.09 ng/ml (p=0,058). Der mittlere IL-36Ra-Spiegel betrug 13,62 pg/ml im BS und 13,26 pg/ml im KP (p=0,348). Der IL-36Ra Serumspiegel der aktiven Gruppe waren signifikant höher (p=0,037). Patienten mit oralen Geschwüren und Beteiligung des zentralen Nervensystems hatten höhere IL-36Ra-Serumspiegel. In der BS Gruppe wurde eine positive Korrelation zwischen IL-36Ra und CRP im Serum gefunden. In der multivariaten Analyse war der IL-36Ra-Spiegel (OR=1067; 95% CI=1001–1137; p=0045) unabhängig mit der Krankheitsaktivität assoziiert.

Schlussfolgerung Nach diesen Erkenntnissen ist nicht klar, ob ein derart geringfügiger Unterschied eine klinische Bedeutung hat. Die Daten legen jedoch nahe, dass die IL-36-Zytokinfamilie möglicherweise eine Rolle im Krankheitsverlauf spielt.

Key words

Interleukin-36 - Immunologie - Pathogenesis - Vasculitis - Behcet’s syndrome

Schlüsselwörter

Interleukin-36 - Studienlage - Pathogenese - Vaskulitis - Behcet-Syndrom

Publikationsverlauf

Artikel online veröffentlicht:
12. November 2021

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