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Horm Metab Res 2021; 53(08): 541-561
DOI: 10.1055/a-1543-6362
Endocrine Care

Associations of the Polymorphisms in ADIPOQ with Circulating Levels of Adiponectin and Lipids: A Meta-Analysis

Mi Su‡
1   Central Laboratory and the Medical Key Laboratory of Clinical Genetics of Sichuan Province, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, P. R. China
,
Aimei Jia‡
2   Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China
,
Yilan He
3   School of Preclinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, P. R. China
,
Yongyan Song
1   Central Laboratory and the Medical Key Laboratory of Clinical Genetics of Sichuan Province, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, P. R. China
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Abstract

The relationships between the rs266729, rs1501299, and rs2241766 polymorphisms in adiponectin gene (ADIPOQ) and circulating levels of adiponectin and lipids remain to be clarified. Databases including PubMed and Embase were searched for eligible studies. The random-effects model was used, and standardized mean difference (SMD) with 95% confidence interval (CI) was calculated to estimate the differences in circulating levels of adiponectin and lipids between the subjects with different genotypes. A total of 12 810, 17 319, and 21 361 subjects were identified in the analyses for the rs266729, rs1501299, and rs2241766 polymorphisms, respectively. G allele carriers of the rs266729 polymorphism had lower levels of adiponectin (SMD=–0.28, 95% CI=–0.43 to–0.12) and high-density lipoprotein cholesterol (HDL-C) (SMD=–0.10, 95% CI=–0.17 to–0.02) than CC homozygotes; T allele carriers of the rs1501299 polymorphism had higher levels of adiponectin (SMD=0.21, 95% CI=0.05 to 0.36) and HDL-C (SMD=0.09, 95% CI=0.04 to 0.15) and lower levels of triglycerides (SMD=–0.06, 95% CI=–0.12 to–0.01) than GG homozygotes; G allele carriers of the rs2241766 polymorphism had lower levels of adiponectin (SMD=–0.18, 95% CI=–0.31 to–0.05) and HDL-C (SMD=–0.12, 95% CI=–0.20 to–0.04) than TT homozygotes. This meta-analysis suggests that the rs266729, rs1501299, and rs2241766 polymorphisms of ADIPOQ are significantly associated with circulating levels of adiponectin and lipids, which may partly explain the associations between these polymorphisms and coronary artery disease.

Key words

coronary artery disease - adiponectin - lipid - polymorphism

Supplementary Material



Publication History

Received: 10 March 2021

Accepted after revision: 09 June 2021

Article published online:
12 August 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Maeda K, Okubo K, Shimomura I. et al cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286-289
    CrossrefPubMedGoogle Scholar
  • 2 Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Diabetes Obes Metab 2007; 9: 282-289
    CrossrefPubMedGoogle Scholar
  • 3 Schindler M, Pendzialek M, Grybel KJ. et al Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts. Hum Reprod (Oxford, England) 2017; 32: 1382-1392
    CrossrefPubMedGoogle Scholar
  • 4 Sayeed M, Gautam S, Verma DP. et al A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. J Biol Chem 2018; 293: 13509-13523
    CrossrefPubMedGoogle Scholar
  • 5 Jo MG, Kim MW, Jo MH. et al Adiponectin homolog osmotin, a potential anti-obesity compound, suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes. Int J Obes (Lond) 2019; 43: 2422-2433
    CrossrefPubMedGoogle Scholar
  • 6 Takahashi Y, Watanabe R, Sato Y. et al Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis. Metabolism 2018; 83: 128-138
    CrossrefPubMedGoogle Scholar
  • 7 Jian M, Kwan JS, Bunting M. et al Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway. J Neuroinflam 2019; 16: 110
    CrossrefPubMedGoogle Scholar
  • 8 Md Sayed AS, Zhao Z, Guo L. et al Serum lectin-like oxidized-low density lipoprotein receptor-1 and adiponectin levels are associated with coronary artery disease accompanied with metabolic syndrome. Iran Red Cresc Med J 2014; 16: e12106
    PubMedGoogle Scholar
  • 9 Wang Y, Zheng A, Yan Y. et al Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in Chinese population. Atherosclerosis 2014; 235: 392-397
    CrossrefPubMedGoogle Scholar
  • 10 Gan L, Yang L, Yan G. Predict value of adiponectin for coronary atherosclerosis plaques according to computed tomography angiography in an asymptomatic population. Clin Imag 2018; 51: 174-179
    CrossrefPubMedGoogle Scholar
  • 11 Kunita E, Yamamoto H, Kitagawa T. et al Association between plasma high-molecular-weight adiponectin and coronary plaque characteristics assessed by computed tomography angiography in conditions of visceral adipose accumulation. Circ J 2012; 76: 1687-1696
    CrossrefPubMedGoogle Scholar
  • 12 Yang Y, Zhang F, Ding R. et al Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects. Thromb Res 2012; 130: 58-64
    CrossrefPubMedGoogle Scholar
  • 13 Zhou L, Xi B, Wei Y. et al Association between adiponectin gene polymorphisms and coronary artery disease across different populations. Thromb Res 2012; 130: 52-57
    CrossrefPubMedGoogle Scholar
  • 14 Kanu JS, Qiu S, Cheng Y. et al Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: A meta-analysis. Lipids Health Dis 2018; 17: 126
    CrossrefPubMedGoogle Scholar
  • 15 Hou H, Ge S, Zhao L. et al An updated systematic review and meta-analysis of association between adiponectin gene polymorphisms and coronary artery disease. Omics 2017; 21: 340-351
    CrossrefPubMedGoogle Scholar
  • 16 Zhao N, Li N, Zhang S. et al Associations between two common single nucleotide polymorphisms (rs2241766 and rs1501299) of ADIPOQ gene and coronary artery disease in type 2 diabetic patients: A systematic review and meta-analysis. Oncotarget 2017; 8: 51994-52005
    CrossrefPubMedGoogle Scholar
  • 17 Zhang H, Mo X, Hao Y. et al Association between polymorphisms in the adiponectin gene and cardiovascular disease: A meta-analysis. BMC Med Genet 2012; 13: 40
    CrossrefPubMedGoogle Scholar
  • 18 Zhou D, Jin Y, Yao F. et al Association between the adiponectin +45T>G genotype and risk of cardiovascular disease: A meta-analysis. Heart Lung Circul 2014; 23: 159-165
    CrossrefPubMedGoogle Scholar
  • 19 De Luis DA, Primo D, Izaola O. et al Role of the variant in adiponectin gene rs266729 on weight loss and cardiovascular risk factors after a hypocaloric diet with the Mediterranean pattern. Nutrition 2019; 60: 1-5
    CrossrefPubMedGoogle Scholar
  • 20 De Luis DA, Calvo SG, Pacheco D. et al Adiponectin gene variant RS rs266729: Relation to lipid profile changes and circulating adiponectin after bariatric surgery. Surg Obes Relat Dis 2018; 14: 1402-1408
    CrossrefPubMedGoogle Scholar
  • 21 Du SX, Lu LL, Liu Y. et al Association of adiponectin gene polymorphisms with the risk of coronary artery disease in patients with nonalcoholic fatty liver disease in a chinese han population. Hepat Mon 2016; 16: e37388
    PubMedGoogle Scholar
  • 22 Yang GZ, Su XH, Wu XF. et al Association of single nucleotide polymorphisms in the proximal promoter region of the adiponectin gene with TCM syndromes in patients with type 2 diabetes. Int J Trad Chin Med 2016; 38: 204-208
    PubMedGoogle Scholar
  • 23 Prior SL, Jones DA, Gill GV. et al Association of the adiponectin rs266729 C>G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort. Diabetes Res Clin Pract 2011; 91: e71-e74
    CrossrefPubMedGoogle Scholar
  • 24 Tsuzaki K, Kotani K, Nagai N. et al Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity. J Endocrinol Invest 2009; 32: 395-400
    CrossrefPubMedGoogle Scholar
  • 25 Huang SJ, Lu JJ, Zhu X. et al Adiponectin level and its polymorphism of -11377C/G and +276G/T genotyes in patients of Zhuang and Han nationlities with metabolic syndrome from Guangxi. Guangxi Med J 2016; 38: 787-791
    PubMedGoogle Scholar
  • 26 Lanas F, Seron P, Saavedra N. et al Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects. Mol Diagn Ther 2015; 19: 197-204
    CrossrefPubMedGoogle Scholar
  • 27 Oliveira CS, Saddi-Rosa P, Crispim F. et al Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects. J Diabetes Complicat 2012; 26: 94-98
    CrossrefPubMedGoogle Scholar
  • 28 Tsuzaki K, Kotani K, Sano Y. et al The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study. Metabolism 2012; 61: 17-21
    CrossrefPubMedGoogle Scholar
  • 29 Chen F, Zhu H, Wu H. et al Correlation of the adiponectin level and gene polymorphism with the essential hypertension. J Ningxia Med Uni 2011; 33: 1019-1022
    PubMedGoogle Scholar
  • 30 Yang H, Ye E, Si G. et al Adiponectin gene polymorphism rs2241766 T/G is associated with response to pioglitazone treatment in type 2 diabetic patients from southern China. PLoS One 2014; 9: e112480
    CrossrefPubMedGoogle Scholar
  • 31 Ye H, Zhuang J. The correlation between adiponectin gene T45G polymorphism and type 2 diabetes in Chinese Han population. Pharm Care Res 2009; 9: 158-160
    PubMedGoogle Scholar
  • 32 De Oliveira R, Moraes TI, Cerda A. et al ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. Diabetol Metab Syndr 2015; 7: 34
    CrossrefPubMedGoogle Scholar
  • 33 Zhang C, Liang X. The relationship between human adiponectin gene polymorphism of Guangxi Zhuang ethnic group and gestational diabetes memtus. J Chin Phys 2014; 16: 1221-1223
    PubMedGoogle Scholar
  • 34 Fleiss JL. The statistical basis of meta-analysis. Statal Meth Med Res 1993; 2: 121
    CrossrefPubMedGoogle Scholar
  • 35 Kacso IM, Farcas MF. Pop IV et al 276G>T polymorphism of the ADIPOQ gene influences plasma adiponectin in type 2 diabetes patients but is not predictive for presence of type 2 diabetes in a Caucasian cohort from Romania. Maedica 2012; 7: 271
    PubMedGoogle Scholar
  • 36 Kacso IM, Trifa AP, Popp RA. et al Association of 276G>T adiponectin gene polymorphism to plasma adiponectin and albuminuria in type 2 diabetic patients. Int Urol Nephrol 2012; 44: 1771-1777
    CrossrefPubMedGoogle Scholar
  • 37 De Luis DA, Izaola O, de la Fuente B. et al rs1501299 polymorphism in the adiponectin gene and their association with total adiponectin levels, insulin resistance and metabolic syndrome in obese subjects. Ann Nutr Metab 2016; 69: 226-231
    CrossrefPubMedGoogle Scholar
  • 38 De Luis DA, Pacheco D, Primo D. et al The Association of SNP276G>T at adiponectin gene with insulin resistance and circulating adiponectin in morbid obese patients after a biliopancreatic diversion surgery. Obes Surg 2017; 27: 3247-3252
    CrossrefPubMedGoogle Scholar
  • 39 Kaur H, Badaruddoza B, Bains V. et al Genetic association of ADIPOQ gene variants (-3971A>G and +276G>T) with obesity and metabolic syndrome in North Indian Punjabi population. PLoS One 2018; 13: e0204502
    CrossrefPubMedGoogle Scholar
  • 40 Gui MH, Li X, Jiang SF. et al Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population. Diabetes Res Clin Pract 2012; 97: 499-504
    CrossrefPubMedGoogle Scholar
  • 41 Leonska-Duniec A, Grzywacz A, Jastrzebski Z. et al ADIPOQ polymorphisms are associated with changes in obesity-related traits in response to aerobic training programme in women. Biol Sport 2018; 35: 165-173
    CrossrefPubMedGoogle Scholar
  • 42 Hsiao T-J, Lin E. A Validation Study of Adiponectin rs266729 gene variant with type 2 diabetes, obesity, and metabolic phenotypes in a taiwanese population. Biochem Genet 2016; 54: 830-841
    CrossrefPubMedGoogle Scholar
  • 43 Kaftan AN, Hussain MK. Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study. Gene 2015; 570: 95-99
    CrossrefPubMedGoogle Scholar
  • 44 Mente A, Meyre D, Lanktree MB. et al Causal relationship between adiponectin and metabolic traits: A Mendelian randomization study in a multiethnic population. PLoS One 2013; 8: e66808
    CrossrefPubMedGoogle Scholar
  • 45 Yang XN. Association of adiponectin gene polymorphism and brachial-ankle pulse in type 2 diabetes patients. Chin J Clin Ration Drug Use 2017; 10: 9-10
    PubMedGoogle Scholar
  • 46 Li JQ, Jiang MN, Zhang RX. et al Association between adiponectin -11377C>G gene polymorphism and effects of atorvastatin therapy. Chin J Clin Pharmacol 2014; 30: 185-187
    PubMedGoogle Scholar
  • 47 Yu J, Ye Y, Wang L. et al An investigation of overweight and obesity in northern Guangxi and association of adiponectin gene polymorphism. Acta Uni Med Anhui 2014; 49: 926-930
    PubMedGoogle Scholar
  • 48 Ye Y, Yu J, Wang L. et al Nonalcoholic fatty liver disease and SNPs -11377C/G in promoter region of adiponectin gene: A correlation study in Han elderly population in Guilin. Chin Gen Pract 2013; 16: 4135-4139
    PubMedGoogle Scholar
  • 49 Wang LJ, Yu J, Ye Y. et al Association of adiponeetin promoter single nucleotide polymorphisms with metabolic syndrome in Hans of the northern Guangxi. Chin J Arterioscler 2013; 21: 822-826
    PubMedGoogle Scholar
  • 50 Pei L, Qiao BM, Jia M. et al Development of an ARM S-TaqM method to detect adiponectin -11377C/G mutation and correlations of -11377C/G SNP with serum adiponectin level and type 2 diabetes. Chin J Lab Diag 2011; 15: 1659-1662
    PubMedGoogle Scholar
  • 51 Min Y, Chen J, Zhu L. et al Relationship between -11377C/G polymorphism on adiponectin gene promoter region and type 2 diabetes mellitus and diabetic nephropathy. Shandong Med J 2011; 51: 65-66
    PubMedGoogle Scholar
  • 52 Cai Q, Shi Y, Li Y. et al Association of gene polymorphism in promoter region of adiponectin gene and carotid artery intima-media thickness in patients with type 2 diabetes mellitus of Fujian. Chin J Endocrinol Metab 2009; 25: 136-138
    PubMedGoogle Scholar
  • 53 Ye F, He L, Li J. et al Association of SNPs in the proximal promoter region of the APM1 gene with obesity and type 2 diabetes. J Xi'an Jiaotong Uni (Medical Sciences) 2008; 29: 74-83
    PubMedGoogle Scholar
  • 54 Jia M, Feng X, Zhang Z. et al Correlation of polymorphism of adiponectin promoter with diabetes type 2 and its complications. Chin J Lab Med 2008; 31: 163-169
    PubMedGoogle Scholar
  • 55 He L, Liu P, Ye F. et al Association of SNPs in proximal promoter region of APM1 gene with serum adiponectin level and type 2 diabetes in Shanxi. Chin J Fourth Military Med Uni 2006; 27: 1493-1495
    PubMedGoogle Scholar
  • 56 Karimi H, Nezhadali M, Hedayati M. Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population. Endocr Regul 2018; 52: 176-184
    CrossrefPubMedGoogle Scholar
  • 57 Mustufa Khan M, Kumar Sonkar G, Alam R. et al Association of ADIPOQ Gene Variant rs266729 with Circulatory Adiponectin Levels in Patients with Type 2 Diabetes in North Indian Population: A Case-Control Study. Biomed Pharmacol J 2017; 10: 407-417
    CrossrefPubMedGoogle Scholar
  • 58 Oguri M, Kato K, Yokoi K. et al Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome. Atherosclerosis 2009; 206: 486-493
    CrossrefPubMedGoogle Scholar
  • 59 Ferguson JF, Phillips CM, Tierney AC. et al Gene-nutrient interactions in the metabolic syndrome: Single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 2010; 91: 794-801
    CrossrefPubMedGoogle Scholar
  • 60 Kang Z, Zhao H, Su H. et al Genetic association analysis of variation in adiponectin gene with essentialhy pertension in Bai population in Dali. Guangdong Med J 2013; 34: 2957-2959
    PubMedGoogle Scholar
  • 61 Bains V, Kaur H. Badaruddoza. Association study of the single-nucleotide polymorphisms -3971G/A and +276G/T in the adiponectin gene with type 2 diabetes in a North Indian Punjabi population. Ann Hum Genet 2020; 84: 235-248
    CrossrefPubMedGoogle Scholar
  • 62 Lacobellis G, Petrone A, Leonetti F. et al Left ventricular mass and+ 276 G/G single nucleotide polymorphism of the adiponectin gene in uncomplicated obesity. Obesity 2006; 14: 368-372
    CrossrefPubMedGoogle Scholar
  • 63 Wang K, Nie X, Liu D. et al The association of adiponectin gene polymorphism with insulin resistance and type 2 diabetes mellitus. J Tianjin Med Uni 2009; 15: 190-193
    PubMedGoogle Scholar
  • 64 De Luis DA, Izaola O, Primo D. et al The Association between Serum Adiponectin Levels and Gene Polymorphism with Coronary Artery Disease in Patients with Essential Hypertension. Tianjin Med J 2014; 42: 903-908
    PubMedGoogle Scholar
  • 65 Li Y, Qin Q, Ren B et al. The Association between serum adiponectin levels and gene polymorphism with coronary artery disease in patients with essential hypertension. Tianjin Med J 2014; 42: 903–908
    PubMed
  • 66 Yang M, Qiu C, Chen W. et al Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality. Biomed Environment Sci 2008; 21: 454-459
    CrossrefPubMedGoogle Scholar
  • 67 Cheng YT, Jiang M, Xin YN. et al Association between adiponectin polymorphism and nonalcoholic fatty liver disease in Han Chinese population in Qingdao. J Pract Med 2015; 31: 1421-1424
    PubMedGoogle Scholar
  • 68 Kang Z, Zhao H, Su H. et al Genetic association analysis of variation in the adiponectin gene promoter with essential hypertension in Dali Bai populations. Chin J Clin (Electronic Edition) 2013; 7: 6430-6433
    PubMedGoogle Scholar
  • 69 Sun H, Gong ZC, Yin JY. et al The association of adiponectin allele 45T/G and -11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients. Br J Clin Pharmacol 2008; 65: 917-926
    CrossrefPubMedGoogle Scholar
  • 70 Pérez-Martínez P, López-Miranda J, Cruz-Teno C. et al Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr 2008; 138: 1609-1614
    CrossrefPubMedGoogle Scholar
  • 71 Jang Y, Chae JS, Koh SJ. et al The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women. Clin Chim Acta 2008; 391: 85-90
    CrossrefPubMedGoogle Scholar
  • 72 Shin MJ, Jang Y, Koh SJ. et al The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. Int J Obesity 2006; 30: 1702-1708
    CrossrefPubMedGoogle Scholar
  • 73 Stenvinkel P, Marchlewska A, Pecoits-Filho R. et al Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. Kidney Int 2004; 65: 274-281
    CrossrefPubMedGoogle Scholar
  • 74 Macias-Gomez NM, Hernandez-Terrones MC, Ramirez-Guerrero AA. et al ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population. PLoS One 2019; 14: e0214080
    CrossrefPubMedGoogle Scholar
  • 75 Czeczuga-Semeniuk E, Galar M, Jarząbek K. et al The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women. Adv Med Sci 2018; 63: 242-248
    CrossrefPubMedGoogle Scholar
  • 76 Zayani N, Omezzine A, Boumaiza I. et al Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study. J Clin Lab Anal 2017; 31
    PubMed
  • 77 Kato H, Ohata A, Samukawa S. et al Effect of adiponectin-encoding gene ADIPOQ single nucleotide polymorphisms +45 and +276 on serum lipid levels after antiretroviral therapy in Japanese patients with HIV-1-infection. J Int Med Res 2016; 44: 297-306
    CrossrefPubMedGoogle Scholar
  • 78 Lee KY, Kang HS, Shin YA. Exercise improves adiponectin concentrations irrespective of the adiponectin gene polymorphisms SNP45 and the SNP276 in obese Korean women. Gene 2013; 516: 271-276
    CrossrefPubMedGoogle Scholar
  • 79 Choe EY, Wang HJ, Kwon O. et al Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. Metabolism 2013; 62: 677-685
    CrossrefPubMedGoogle Scholar
  • 80 Lee JY, Cho JK, Hong HR. et al Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults. Eur J Appl Physiol 2012; 112: 623-629
    CrossrefPubMedGoogle Scholar
  • 81 Leu HB, Chung CM, Lin SJ. et al Adiponectin gene polymorphism is selectively associated with the concomitant presence of metabolic syndrome and essential hypertension. PLoS One 2011; 6: e19999
    CrossrefPubMedGoogle Scholar
  • 82 Xu J, Zhuo Q, Tian Y. et al Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China. J Hygiene Res 2013; 42: 353-359
    PubMedGoogle Scholar
  • 83 Gong LQ, Li L, Zhao XG. et al Association of single nucleotide polymorphisms of the adiponectin gene and plasma levels of adiponectin with risk of nonalcoholic fatty liver disease. J Xinjiang Med Uni 2013; 36: 860-864
    PubMedGoogle Scholar
  • 84 Chen F, Wu H, Wang J. et al Relationships between adiponectin level and its gene polymorphism with coronary heart disease. J Clin Cardiol 2011; 27: 284-287
    PubMedGoogle Scholar
  • 85 Wang Z, Xia B, Jiang L, Chen Q. et al Association between adiponectin gene polymorphism and Non-alcoholic fatty liver. J Clin Intern Med 2008; 25: 736-740
    PubMedGoogle Scholar
  • 86 Arnaiz-Villena A, Fernandez-Honrado M, Rey D. et al Amerindians show association to obesity with adiponectin gene SNP45 and SNP276: population genetics of a food intake control and "thrifty" gene. Mol Biol Rep 2013; 40: 1819-1826
    CrossrefPubMedGoogle Scholar
  • 87 Su M, Zhang X, Su S. Association of adiponectin genotype polymorphisms at positions 45 and 276 with obstructive sleep apnea hypopnea syndrome. J Nanjing Med Uni 2009; 23: 279-283
    CrossrefPubMedGoogle Scholar
  • 88 Bai YP, Xiong W, Lin W. et al Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases. Hypertens Res 2010; 33: 1066-1070
    CrossrefPubMedGoogle Scholar
  • 89 Sone Y, Yamaguchi K, Fujiwara A. et al Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males. J Nutr Sci Vitaminol 2010; 56: 123-131
    CrossrefPubMedGoogle Scholar
  • 90 Ronconi V, Turchi F, Rilli S. et al Metabolic syndrome in primary aldosteronism and essential hypertension: relationship to adiponectin gene variants. Nutr Metab Cardiovasc Dis 2010; 20: 93-100
    CrossrefPubMedGoogle Scholar
  • 91 Chung HK, Chae JS, Hyun YJ. et al Influence of adiponectin gene polymorphisms on adiponectin level and insulin resistance index in response to dietary intervention in overweight-obese patients with impaired fasting glucose or newly diagnosed type 2 diabetes. Diabetes Care 2009; 32: 552-558
    CrossrefPubMedGoogle Scholar
  • 92 Melistas L, Mantzoros CS, Kontogianni M. et al Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women. Eur J Endocrinol 2009; 161: 845-852
    CrossrefPubMedGoogle Scholar
  • 93 Mousavinasab F, Tahtinen T, Jokelainen J. et al Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. Mol Genet Metab 2006; 87: 147-151
    CrossrefPubMedGoogle Scholar
  • 94 Kang ES, Park SY, Kim HJ. et al The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes. Diabetes Care 2005; 28: 1139-1144
    CrossrefPubMedGoogle Scholar
  • 95 Lee Y, Lee N, Cho YM. et al Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabetic Med 2005; 22: 569-575
    CrossrefPubMedGoogle Scholar
  • 96 Jang Y, Lee JH, Chae JS. et al Association of the 276G→T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. Am J Clin Nutr 2005; 82: 760–-7767
    CrossrefPubMedGoogle Scholar
  • 97 Boumaiza I, Omezzine A, Rejeb J. et al Association between eight adiponectin polymorphisms, obesity, and metabolic syndrome parameters in Tunisian volunteers. Metab Syndr Relat Disord 2011; 9: 419-426
    CrossrefPubMedGoogle Scholar
  • 98 Garba M, Khabour OF, Alzoubi KH. et al The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients. Dermatol Res Pract 2020; 3176521
    PubMedGoogle Scholar
  • 99 Ergoren MC, Soyler G, Sah H. et al Investigation of potential genomic biomarkers for obesity and personalized medicine. Int J Biol Macromol 2019; 122: 493-498
    CrossrefPubMedGoogle Scholar
  • 100 Hussain MK, Deli FA, Algenabi AHA. et al Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population. Gene 2018; 662: 118-122
    CrossrefPubMedGoogle Scholar
  • 101 Su QJ, Chen QY. Gene Polymorphism of Adiponectin in Han Nationality with Type 2 Diabetes Mellitus from Guangxi. China Pharm 2014; 17: 540-543
    PubMedGoogle Scholar
  • 102 Kang Z, Su H, Zhang Y. et al Genetic association analysis of the adiponectin polymorphisms in type 2 diabetes of Bai nationality at Dali area. Lab Med Clin 2013; 10: 3122-3124
    PubMedGoogle Scholar
  • 103 Chen X, Li X, Lin X. et al Association of single nucleotide polymorphism at position 45 in adiponectin gene with plasma adiponectin level and insulin resistance in obesity. Int J Radiation Med Nuclear Med 2012; 36: 269-273
    PubMedGoogle Scholar
  • 104 Kang X, Tang X, He C. Correlation of 45T/G polymorphism adiponectin gene with type 2 diabetes in Kazaks of Xinjiang. J China Med Uni 2012; 41: 454-457
    PubMedGoogle Scholar
  • 105 Zhou N, Zhuo J, Wang J. et al Correlation of adiponectin gene SNP+ 45T/G polymorphism and premature coronary heart disease of Han ethnic males. Natl Med J China 2011; 91: 3413-3416
    PubMedGoogle Scholar
  • 106 Xu Y, Zhao Y, Yang H. et al The Relationship between Adiponectin Gene +45(T/G) Polymorphismand 8-Isoprostaglandin F2a in T2DM. Tianjin Med J 2011; 39: 586-588
    PubMedGoogle Scholar
  • 107 Yang H, Zhao Y, Xu Y. et al The Relationship Between Adiponectin Gene +45 (T/G) polymorphism and type 2 diabetes mellitus in Kunming Han Population. J Pract Med 2011; 27: 44-46
    PubMedGoogle Scholar
  • 108 Xu L, Ling W. Correlation between adiponectin gene SNP+45 T/G polymorphism and coronary heart disease. Chin J Pathophysiol 2010; 26: 1064-1068
    PubMedGoogle Scholar
  • 109 Kang Z, Sun C, Zhao H. et al Correlation between polymorphism of adiponectin gene and type 2 diabetes mellitus in Bai and Han population at Dali area. Chin J Diabetes 2008; 16: 718-720
    PubMedGoogle Scholar
  • 110 Liu L, Sun L, Xu J. The relationship between adiponectin gene polymorphism and gestational diabetes mellitu. Guangdong Med J 2006; 27: 1822-1824
    PubMedGoogle Scholar
  • 111 Du P, Xu M, Hong J. et al The relationship between adiponectin gene polymorphism and insulin resistance. Chin J Diabetes Mellitus 2004; 12: 393-396
    PubMedGoogle Scholar
  • 112 Foucan L, Maimaitiming S, Larifla L. et al Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients. J Diabetes Invest 2014; 5: 192-198
    CrossrefPubMedGoogle Scholar
  • 113 Yan CJ, Li SM, Xiao Q. et al Influence of serum adiponectin level and SNP +45 polymorphism of adiponectin gene on myocardial fibrosis. J Zhejiang Univ Sci B 2013; 14: 721-728
    CrossrefPubMedGoogle Scholar
  • 114 Curti ML, Pires MM, Barros CR. et al Associations of the TNF-alpha-308 G/A, IL6-174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk. Diabetol Metab Syndr 2012; 4: 49-57
    CrossrefPubMedGoogle Scholar
  • 115 Mohammadzadeh G, Zarghami N. Associations between single-nucleotide polymorphisms of the adiponectin gene, serum adiponectin levels and increased risk of type 2 diabetes mellitus in Iranian obese individuals. Scand J Clin Lab Invest 2009; 69: 764-771
    CrossrefPubMedGoogle Scholar
  • 116 Haap M, Machicao F, Stefan N. et al Genetic determinants of insulin action in polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2005; 113: 275-281
    Article in Thieme ConnectPubMedGoogle Scholar
  • 117 González-Sánchez JL, Zabena CA, Martínez-Larrad MT. et al An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obesity Res 2005; 13: 807-812
    CrossrefPubMedGoogle Scholar
  • 118 Zhang W, Zhang H, Zhou X. et al The relationship between RETN, LEPR and ADIPOQ gene polymorphisms and the risk of type 2 diabetes and the lipid metabolism in Chinese Han population. J Wenzhou Med Uni 2018; 49: 807-813
    PubMedGoogle Scholar
  • 119 Zhao T, Zhao J. Genetic effects of adiponectin on blood lipids and blood pressure. Clin Endocrinol 2011; 74: 214-222
    CrossrefPubMedGoogle Scholar
  • 120 Cieslak J, Bartz M, Stachowiak M. et al Effect of three common SNPs in 5'-flanking region of LEP and ADIPOQ genes on their expression in Polish obese children and adolescents. Mol Biol Rep 2012; 39: 3951-3955
    CrossrefPubMedGoogle Scholar
  • 121 Fredriksson J, Carlsson E, Orho-Melander M. et al A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects. Int J Obes (Lond) 2006; 30: 226-232
    CrossrefPubMedGoogle Scholar
  • 122 Qiao L, Maclean PS, Schaack J. et al C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 2005; 54: 1744-1754
    CrossrefPubMedGoogle Scholar
  • 123 Lee JD, Hsiao KM, Chang PJ. et al A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels. Biochim Biophys Acta Mol Basis Disease 2017; 1863: 1690-1698
    CrossrefPubMedGoogle Scholar
  • 124 Yanai H, Yoshida H. Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives. Int J Mol Sci 2019; 20: 1190
    CrossrefPubMedGoogle Scholar
  • 125 Christou GA, Tellis KC, Elisaf MC. et al High density lipoprotein is positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment. Hormones (Athens, Greece) 2012; 11: 178-188
    CrossrefPubMedGoogle Scholar
  • 126 Kazumi T, Kawaguchi A, Hirano T. et al Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 2004; 53: 589-593
    CrossrefPubMedGoogle Scholar
  • 127 Kangas-Kontio T, Huotari A, Ruotsalainen H. et al Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease. Atherosclerosis 2010; 210: 479-485
    CrossrefPubMedGoogle Scholar
  • 128 Matsuura F, Oku H, Koseki M. et al Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver. Biochem Biophys Res Commun 2007; 358: 1091-1095
    CrossrefPubMedGoogle Scholar
  • 129 Kitajima K, Miura S, Yamauchi T. et al Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells. Biochem Biophys Res Commun 2011; 411: 305-311
    CrossrefPubMedGoogle Scholar
  • 130 Tomono Y, Hiraishi C, Yoshida H. Age and sex differences in serum adiponectin and its association with lipoprotein fractions. Ann Clin Biochem 2018; 55: 165-171
    CrossrefPubMedGoogle Scholar