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CC BY-NC-ND 4.0 · Planta Medica International Open 2021; 8(03): e114-e121
DOI: 10.1055/a-1543-1261
Original Papers

Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity

Qian Yang
1   State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4   Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Yinqing Li
2   Shineway Pharmaceutical Group Ltd., Shijiazhuang, PR China
3   Hebei key Laboratory of Famous Classical Formulas and TCM Quality Process Control, Shijiazhuang, PR China
,
Xizi Liu
1   State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4   Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Shiyi Han
1   State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4   Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Siyang Fan
1   State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4   Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
› Author Affiliations Funding This work was supported by grants from the National Natural Science Foundation of China (No. 81603279), the National Science and Technology Project of China (No. 2018ZX09731–016), and the S&T Program of Hebei (20272502D).
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Abstract

The rhizome of Alisma orientale (sam.) Juz. is used in clinics for eliminating dampness, reducing edema, and promoting diuresis. This study aimed to elucidate the compounds and investigate their nuclear factor-kappa inhibitory activities in human embryonic kidney 293 cells. A new triterpene, alismaketone B (1); a new natural nortriterpene, noralisolic acid A (2); and 13 known protostane-type triterpenes were isolated from the rhizome of A. orientale. The new structures and their absolute configurations were established using HRESIMS, NMR, and electronic circular dichroism experiments. All isolated compounds were evaluated for their inhibitory activity on NF-κB. The compounds 8, 9, 10, and 14 showed moderate NF-κB inhibitory activities with their IC50 values being 64.7, 32.3, 47.3, and 37.3 μM, respectively.

Key words

Alisma orientale - Alismataceae - triterpenoids - nuclear factor-kappa B

Supplementary Material



Publication History

Received: 10 March 2021
Received: 23 June 2021

Accepted: 25 June 2021

Article published online:
25 August 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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