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CC BY-NC-ND 4.0 · Synthesis 2021; 53(21): 3963-3976
DOI: 10.1055/a-1541-1761
DOI: 10.1055/a-1541-1761
short review
Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications
The authors gratefully acknowledge the financial support from Science Foundation Ireland under the SFI Industry Fellowship programme for the project entitled ‘Development of Continuous Biocatalysed Processes – Continuous Biocatalysed Chemicals (CATCH)’ (19/IFA/7420, to MB).
Abstract
Continuous flow chemistry is becoming an established technology platform that finds frequent application in industrial chemical manufacture with support and endorsements by the FDA for pharmaceuticals. Amongst the various advantages that are commonly cited for flow chemistry over batch processing, sustainability continues to require further advances and joint efforts by chemists and chemical engineers in both academia and industry. This short review highlights developments between 2015 and early 2021 that positively impact on the green credentials associated with flow chemistry, specifically when applied to the preparation of pharmaceuticals. An industrial perspective on current challenges is provided to whet discussion and stimulate further investment towards achieving greener modern synthetic technologies.
1 Introduction
2 Subject Areas and Relevant Case Studies
3 Industrial Outlook on Future Sustainability Driven through Continuous Manufacturing Approaches
4 Conclusions and Outlook
Key words
flow chemistry - green chemistry - sustainable synthesis - process optimization - in-line purification - reaction telescopingPublikationsverlauf
Eingereicht: 03. Juni 2021
Angenommen nach Revision: 30. Juni 2021
Accepted Manuscript online:
30. Juni 2021
Artikel online veröffentlicht:
16. August 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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