Der selektive Nachweis von HLA-spezifischen B-Gedächtniszellen

Zusammenfassung

In der Transplantationsdiagnostik werden die Seren der Patienten auf der Warteliste jedes Quartal auf präexistierende Anti-HLA-Antikörper untersucht. Jedoch kann die Existenz von zirkulierenden peripheren Antikörpern, die von knochenmarkresidierenden Plasmazellen sezerniert wurden, keine zuverlässige Information über das Zellkompartment von B-Gedächtniszellen geben. Die Exposition mit einem inkompatiblen HLA-Antigen kann immer die Aktivierung vorhandener B-Gedächtniszellen auslösen. Die Analyse von B-Gedächtniszellen ermöglicht die Erhebung von belastbaren Daten über den individuellen Immunstatus eines Patienten.

Abstract

In transplantation diagnosis, the standard operating procedure is the quarterly screening of pre-existing anti-HLA antibodies in peripheral sera of patients from the waiting list. Yet, the existence of circulating peripheral antibodies that are secreted by bone marrow-residing plasma cells cannot be translated into reliable information on the memory B cell compartment. The exposure to a mismatched HLA antigen could always be a trigger for the activation of memory B cell immunity. The detection of HLA-specific memory B cells would allow elevating resilient data about the patient individual immune status.

Schlüsselwörter

Transplantationsdiagnostik - Anti-HLA-Antikörper - B-Gedächtniszellen - individueller Immunstatus

Key words

transplantation diagnostic - anti-HLA antibodies - memory B cells - individual immune status

^* Geteilte Letztautorenautorenschaft.

Publication History

Article published online:
22 November 2021

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