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Planta Med 2022; 88(12): 1092-1110
DOI: 10.1055/a-1517-6882
Pharmacokinetics
Reviews

Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials

Inés Moragrega
1   Departament de Psicobiologia, Facultat de Psicologia, Universitat de València, Valencia, Spain
,
José Luis Ríos 
2   Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Valencia, Spain
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Abstract

Depression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. In a previous review, we compiled and examined studies of medicinal plants that had been evaluated in preclinical assays, including existing data on 155 species studied and reported as antidepressants or as sources of active principles for treating this condition. This review will thus limit its focus to the 95 clinical trials found in PubMed among the 670 articles on antidepressant-like medicinal plants. To this end, we have reviewed the publications cited in the Cochrane Database of Systematic Reviews, PubMed, and the Science Citation Index from 2000 to 2020. Our review emphasizes those species that have demonstrated the greatest pharmacological potential when studied for their antidepressant properties in humans through clinical trials. Saffron, turmeric, St. Johnʼs wort, ginkgo, kava, and golden root are the most relevant plants that have provided important evidence for the treatment of depression in clinical trials.

Key words

antidepressant - medicinal plants - clinical trials - natural products - curcumin - saffron


Publikationsverlauf

Eingereicht: 05. März 2021

Angenommen nach Revision: 17. Mai 2021

Artikel online veröffentlicht:
22. Juni 2021

© 2021. Thieme. All rights reserved.

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  • References

  • 1 American Psychiatric Association. Diagnostic and statistical Manual for mental Disorders, 5a ed (DSM-5). Arlington: American Psychiatric Publishing; 2013
    CrossrefGoogle Scholar
  • 2 Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008; 455: 894-902
    CrossrefPubMedGoogle Scholar
  • 3 World Health Organization. Depression and other common mental Disorders. Global Health Estimates. Geneve: WHO; 2017
    Google Scholar
  • 4 Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. Prevalence of depression in the community from 30 countries between 1994 and 2014. Sci Rep 2018; 8: 2861
    CrossrefPubMedGoogle Scholar
  • 5 Saveanu RV, Nemeroff CB. Etiology of depression: genetic and environmental factors. Psychiatr Clin North Am 2012; 35: 51-71
    CrossrefPubMedGoogle Scholar
  • 6 Kaymaz N, van Os J, Loonen AJM, Nolen WA. Evidence that patients with single versus recurrent depressive episodes are differentially sensitive to treatment discontinuation: a meta-analysis of placebo-controlled randomized trials. J Clin Psychiatry 2008; 69: 1423-1436
    CrossrefPubMedGoogle Scholar
  • 7 Carvalho LA, Pariante CM. In vitro modulation of the glucocorticoid receptor by antidepressants. Stress 2008; 11: 411-424
    CrossrefPubMedGoogle Scholar
  • 8 Cepeda MS, Stang P, Makadia R. Depression is associated with high levels of C-reactive protein and low levels of fractional exhaled nitric oxide: results from the 2007–2012 National Health and Nutrition Examination Surveys. J Clin Psychiatry 2016; 77: 1666-1671
    CrossrefPubMedGoogle Scholar
  • 9 Moragrega I, Ríos JL. Medicinal plants in the treatment of depression: evidence from preclinical studies. Planta Med 2021; DOI: 10.1055/a-1338-1011.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 10 Dantzer R, OʼConnor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9: 46-56
    CrossrefPubMedGoogle Scholar
  • 11 Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 2016; 16: 22-34
    CrossrefPubMedGoogle Scholar
  • 12 Jha MK, Trivedi MH. Personalized antidepressant selection and pathway to novel treatments: clinical utility of targeting inflammation. Int J Mol Sci 2018; 19: 233
    CrossrefPubMedGoogle Scholar
  • 13 Setiawan E, Attwells S, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Xu C, Sharma S, Kish S, Houle S, Meyer JH. Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study. Lancet Psychiatry 2018; 5: 339-347
    CrossrefPubMedGoogle Scholar
  • 14 Zunszain PA, Hepgul N, Pariante CM. Inflammation and depression. Curr Topics Behav Neurosci 2013; 14: 135-151
    CrossrefPubMedGoogle Scholar
  • 15 Christmas DM, Potokar J, Davies SJ. A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase. Neuropsychiatr Dis Treat 2011; 7: 431-439
    PubMedGoogle Scholar
  • 16 Pariante CM. Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. Eur Neuropsychopharmacol 2017; 27: 554-559
    CrossrefPubMedGoogle Scholar
  • 17 Frodl TS, Koutsouleris N, Bottlender R, Born C, Jäger M, Scupin I, Reiser M, Möller HJ, Meisenzahl EM. Depression-related variation in brain morphology over 3 years: effects of stress?. Arch Gen Psychiatry 2008; 65: 1156-1165
    CrossrefPubMedGoogle Scholar
  • 18 Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL. Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol 2015; 35: 406-410
    CrossrefPubMedGoogle Scholar
  • 19 Sahebkar A, Cicero AFG, Simental-Mendía LE, Aggarwal BB, Gupta SC. Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2016; 107: 234-242
    CrossrefPubMedGoogle Scholar
  • 20 Sarris J. Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytother Res 2018; 32: 1147-1162
    CrossrefPubMedGoogle Scholar
  • 21 Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nat Med 2001; 7: 541-547
    CrossrefPubMedGoogle Scholar
  • 22 Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G, Kubera M, Bob P, Lerer B, Maj M. The inflammatory and neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 2009; 24: 27-53
    CrossrefPubMedGoogle Scholar
  • 23 Raison CL, Miller AH. Is depression an inflammatory disorder?. Curr Psychiatry Rep 2011; 13: 467-475
    CrossrefPubMedGoogle Scholar
  • 24 Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 2012; 36: 764-785
    CrossrefPubMedGoogle Scholar
  • 25 Lopresti AL, Hood SD, Drummond PD. Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol 2012; 26: 1512-1524
    CrossrefPubMedGoogle Scholar
  • 26 Vadnie CA, McClung CA. Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus. Neural Plast 2017; 2017: 1504507
    CrossrefPubMedGoogle Scholar
  • 27 Miller AH, Raison CL. Immune system contributions to the pathophysiology of depression. Focus 2008; 6: 36-45
    CrossrefPubMedGoogle Scholar
  • 28 Coleman JA, Green EM, Gouaux E. X-ray structures and mechanism of the human serotonin transporter. Nature 2016; 532: 334-339
    CrossrefPubMedGoogle Scholar
  • 29 Zhang FH, Wang ZM, Liu YT, Huang JS, Liang S, Wu HH, Xu YT. Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott. J Ethnopharmacol 2019; 241: 111967
    CrossrefPubMedGoogle Scholar
  • 30 Matveychuk D, Thomas RK, Swainson J, Khullar A, MacKay MA, Baker GB, Dursun SM. Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers. Ther Adv Psychopharmacol 2020; 10: 2045125320916657
    CrossrefPubMedGoogle Scholar
  • 31 Dhingra D, Sharma A. A review on antidepressant plants. Nat Prod Rad 2006; 5: 144-152
    PubMedGoogle Scholar
  • 32 Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol 2011; 21: 841-860
    CrossrefPubMedGoogle Scholar
  • 33 Farahani MS, Bahramsoltani R, Farzaei MH, Abdollahi M, Rahimi R. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. Rev Neurosci 2015; 26: 305-321
    CrossrefPubMedGoogle Scholar
  • 34 Lee G, Bae H. Therapeutic effects of phytochemicals and medicinal herbs on depression. Biomed Res Int 2017; 2017: 6596241
    PubMedGoogle Scholar
  • 35 Bakhshaeil S. Effect of nine medicinal plants as a traditional treatment on depression. J Appl Pharm 2017; 9: 244
    PubMedGoogle Scholar
  • 36 Rahman MR, Ali M, Sharif M, Tajmin A. A review study on the traditional plants has potential antidepressant property. MOJ Cell Sci Rep 2017; 4: 00100
    CrossrefPubMedGoogle Scholar
  • 37 Muszyńska B, Łojewski M, Rojowski J, Opoka W, Sułkowska-Ziaja K. Natural products of relevance in the prevention and supportive treatment of depression. Psychiatr Pol 2015; 49: 435-453
    CrossrefPubMedGoogle Scholar
  • 38 Dong X, Yang C, Cao S, Gan Y, Sun H, Gong Y, Yang H, Yin X, Lu Z. Tea consumption and the risk of depression: a meta-analysis of observational studies. Aust N Z J Psychiatry 2015; 49: 334-345
    CrossrefPubMedGoogle Scholar
  • 39 Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs 2013; 27: 301-319
    CrossrefPubMedGoogle Scholar
  • 40 Puttarak P, Dilokthornsakul P, Saokaew S, Dhippayom T, Kongkaew C, Sruamsiri R, Chuthaputti A, Chaiyakunapruk N. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A systematic review and meta-analysis. Sci Rep 2017; 7: 10646
    CrossrefPubMedGoogle Scholar
  • 41 Chusak C, Thilavech T, Henry CJ, Adisakwattana S. Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial. BMC Complement Altern Med 2018; 18: 6
    CrossrefPubMedGoogle Scholar
  • 42 Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord 2018; 227: 330-337
    CrossrefPubMedGoogle Scholar
  • 43 Ulbricht C, Conquer J, Costa D, Hollands W, Iannuzzi C, Isaac R, Jordan JK, Ledesma N, Ostroff C, Serrano JM, Shaffer MD, Varghese M. An evidence-based systematic review of saffron (Crocus sativus) by the Natural Standard Research Collaboration. J Diet Suppl 2011; 8: 58-114
    CrossrefPubMedGoogle Scholar
  • 44 Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol 2014; 29: 517-527
    CrossrefPubMedGoogle Scholar
  • 45 Tabeshpour J, Sobhani F, Sadjadi SA, Hosseinzadeh H, Mohajeri SA, Rajabi O, Taherzadeh Z, Eslami S. A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression. Phytomedicine 2017; 36: 145-152
    CrossrefPubMedGoogle Scholar
  • 46 Tóth B, Hegyi P, Lantos T, Szakács Z, Kerémi B, Varga G, Tenk J, Pétervári E, Balaskó M, Rumbus Z, Rakonczay Z, Bálint ER, Kiss T, Csupor D. The efficacy of saffron in the treatment of mild to moderate depression: a meta-analysis. Planta Med 2019; 85: 24-31
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 47 Khaksarian M, Behzadifar M, Behzadifar M, Alipour M, Jahanpanah F, Re TS, Firenzuoli F, Zerbetto R, Bragazzi NL. The efficacy of Crocus sativus (Saffron) versus placebo and fluoxetine in treating depression: a systematic review and meta-analysis. Psychol Res Behav Manag 2019; 12: 297-305
    CrossrefPubMedGoogle Scholar
  • 48 Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of saffron versus fluoxetine in treatment of mild to moderate postpartum depression: a double-blind, randomized clinical trial. Pharmacopsychiatry 2017; 50: 64-68
    PubMedGoogle Scholar
  • 49 Kashani L, Esalatmanesh S, Eftekhari F, Salimi S, Foroughifar T, Etesam F, Safiaghdam H, Moazen-Zadeh E, Akhondzadeh S. Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial. Arch Gynecol Obstet 2018; 297: 717-724
    CrossrefPubMedGoogle Scholar
  • 50 Milajerdi A, Jazayeri S, Shirzadi E, Hashemzadeh N, Azizgol A, Djazayery A, Esmaillzadeh A, Akhondzadeh S. The effects of alcoholic extract of saffron (Crocus sativus L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial. Complement Ther Med 2018; 41: 196-202
    CrossrefPubMedGoogle Scholar
  • 51 Marx W, Lane M, Rocks T, Ruusunen A, Loughman A, Lopresti A, Marshall S, Berk M, Jacka F, Dean OM. Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutr Rev 2019; 77: 557-571
    CrossrefPubMedGoogle Scholar
  • 52 Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med 2016; 13: 195-199
    CrossrefPubMedGoogle Scholar
  • 53 Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, Brunetti L, Menghini L. Phytotherapic use of the Crocus sativus L. (saffron) and its potential applications: A brief overview. Phytother Res 2018; 32: 2364-2375
    CrossrefPubMedGoogle Scholar
  • 54 Yang X, Chen X, Fu Y, Luo Q, Du L, Qiu H, Qiu T, Zhang L, Meng H. Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. Neuropsychiatr Dis Treat 2018; 14: 1297-1305
    CrossrefPubMedGoogle Scholar
  • 55 Jelodar G, Javid Z, Sahraian A, Jelodar S. Saffron improved depression and reduced homocysteine level in patients with major depression: A randomized, double-blind study. Avicenna J Phytomed 2018; 8: 43-50
    PubMedGoogle Scholar
  • 56 Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010; 67: 446-457
    CrossrefPubMedGoogle Scholar
  • 57 Lopresti AL. Cognitive behaviour therapy and inflammation: A systematic review of its relationship and the potential implications for the treatment of depression. Aust N Z J Psychiatry 2017; 51: 565-582
    CrossrefPubMedGoogle Scholar
  • 58 Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: a randomized controlled trial. Chin J Integr Med 2015; 21: 332-338
    CrossrefPubMedGoogle Scholar
  • 59 Bergman J, Miodownik C, Bersudsky Y, Sokolik S, Lerner PP, Kreinin A, Polakiewicz J, Lerner V. Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study. Clin Neuropharmacol 2013; 36: 73-77
    CrossrefPubMedGoogle Scholar
  • 60 Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord 2014; 167: 368-375
    CrossrefPubMedGoogle Scholar
  • 61 Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res 2014; 28: 579-585
    CrossrefPubMedGoogle Scholar
  • 62 Lopresti AL, Maes M, Meddens MJ, Maker GL, Arnoldussen E, Drummond PD. Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. Eur Neuropsychopharmacol 2015; 25: 38-50
    CrossrefPubMedGoogle Scholar
  • 63 Ng QX, Koh SSH, Chan HW, Ho CYX. Clinical use of curcumin in depression: a meta-analysis. J Am Med Dir Assoc 2017; 18: 503-508
    CrossrefPubMedGoogle Scholar
  • 64 Kanchanatawan B, Tangwongchai S, Sughondhabhirom A, Suppapitiporn S, Hemrunrojn S, Carvalho AF, Maes M. Add-on treatment with curcumin has antidepressive effects in Thai patients with major depression: results of a randomized double-blind placebo-controlled study. Neurotox Res 2018; 33: 621-633
    CrossrefPubMedGoogle Scholar
  • 65 Panahi Y, Badeli R, Karami GR, Sahebkar A. Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder. Phytother Res 2015; 29: 17-21
    CrossrefPubMedGoogle Scholar
  • 66 Al-Karawi D, Al Mammori DA, Tayyar Y. The role of curcumin administration in patients with major depressive disorder: mini meta-analysis of clinical trials. Phytother Res 2016; 30: 175-183
    CrossrefPubMedGoogle Scholar
  • 67 Lopresti AL, Drummond PD. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. J Affect Disord 2017; 207: 188-196
    CrossrefPubMedGoogle Scholar
  • 68 Lopresti AL. The problem of curcumin and its bioavailability: could its gastrointestinal influence contribute to its overall health-enhancing effects?. Adv Nutr 2018; 9: 41-50
    CrossrefPubMedGoogle Scholar
  • 69 Kaufmann FN, Gazal M, Bastos CR, Kaster MP, Ghisleni G. Curcumin in depressive disorders: An overview of potential mechanisms, preclinical and clinical findings. Eur J Pharmacol 2016; 784: 192-198
    CrossrefPubMedGoogle Scholar
  • 70 Antony B, Merina B, Iyer S, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95 CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Indian J Pharm Sci 2008; 70: 445-4590
    CrossrefPubMedGoogle Scholar
  • 71 Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 2011; 74: 664-669
    CrossrefPubMedGoogle Scholar
  • 72 Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27: 24-31
    CrossrefPubMedGoogle Scholar
  • 73 Dantzer R, OʼConnor JC, Lawson MA, Kelley KW. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 2011; 36: 426-436
    CrossrefPubMedGoogle Scholar
  • 74 Maes M, Berk M, Goehler L, Song C, Anderson G, Gałecki P, Leonard B. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med 2012; 10: 66
    Google Scholar
  • 75 Lotrich FE. Inflammatory cytokine-associated depression. Brain Res 2015; 1617: 113-125
    CrossrefPubMedGoogle Scholar
  • 76 Ghandadi M, Sahebkar A. Curcumin: an effective inhibitor of interleukin-6. Curr Pharm Des 2017; 23: 921-931
    CrossrefPubMedGoogle Scholar
  • 77 Hannestad J, DellaGioia N, Bloch M. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 2011; 36: 2452-2459
    CrossrefPubMedGoogle Scholar
  • 78 Eyre HA, Air T, Pradhan A, Johnston J, Lavretsky H, Stuart MJ, Baune BT. A meta-analysis of chemokines in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2016; 68: 1-8
    CrossrefPubMedGoogle Scholar
  • 79 Hewlings SJ, Kalman DS. Curcumin: a review of itsʼ effects on human health. Foods 2017; 6: E92
    CrossrefPubMedGoogle Scholar
  • 80 Derosa G, Maffioli P, Simental-Mendía LE, Bo S, Sahebkar A. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2016; 111: 394-404
    CrossrefPubMedGoogle Scholar
  • 81 Mantzorou M, Pavlidou E, Vasios G, Tsagalioti E, Giaginis C. Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data. Phytother Res 2018; 32: 957-975
    CrossrefPubMedGoogle Scholar
  • 82 Lopresti AL. Curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies. J Psychopharmacol 2017; 31: 287-302
    CrossrefPubMedGoogle Scholar
  • 83 De Feudis FV. Ginkgo biloba Extract (EGb 761). From Chemistry to the Clinic. Wiesbaden: Ullstein Medical; 1998: 1-6
    Google Scholar
  • 84 Meston CM, Rellini AH, Telch MJ. Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women. Arch Sex Behav 2008; 37: 530-547
    CrossrefPubMedGoogle Scholar
  • 85 Beaubrun G, Gray GE. A review of herbal medicines for psychiatric disorders. Psychiatr Serv 2000; 51: 1130-1134
    CrossrefPubMedGoogle Scholar
  • 86 Ashton AK, Ahrens K, Gupta S, Masand PS. Antidepressant-induced sexual dysfunction and Ginkgo biloba . Am J Psychiatry 2000; 157: 836-837
    CrossrefPubMedGoogle Scholar
  • 87 Waddell DL, Hummel ME, Sumners AD. Three herbs you should get to know. Am J Nurs 2001; 101: 48-53
    CrossrefPubMedGoogle Scholar
  • 88 Kang BJ, Lee SJ, Kim MD, Cho MJ. A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction. Hum Psychopharmacol 2002; 17: 279-284
    CrossrefPubMedGoogle Scholar
  • 89 Wheatley D. Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs. Hum Psychopharmacol 2004; 19: 545-548
    CrossrefPubMedGoogle Scholar
  • 90 Hemmeter U, Annen B, Bischof R, Brüderlin U, Hatzinger M, Rose U, Holsboer-Trachsler E. Polysomnographic effects of adjuvant Ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsychiatry 2001; 34: 50-59
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 91 Linde K, Mulrow CD. St Johnʼs wort for depression. Cochrane Database Syst Rev 2000; (02) CD000448
    PubMedGoogle Scholar
  • 92 Linde K, Mulrow CD, Berner M, Egger M. St Johnʼs wort for depression. Cochrane Database Syst Rev 2005; (02) CD000448
    PubMedGoogle Scholar
  • 93 Linde K, Berner MM, Kriston L. St Johnʼs wort for major depression. Cochrane Database Syst Rev 2008; (04) CD000448
    PubMedGoogle Scholar
  • 94 Rahimi R, Nikfar S, Abdollahi M. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 118-127
    CrossrefPubMedGoogle Scholar
  • 95 Szegedi A, Kohnen R, Dienel A, Kieser M. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St Johnʼs wort): randomised controlled double blind non-inferiority trial versus paroxetine. BMJ 2005; 330: 503
    CrossrefPubMedGoogle Scholar
  • 96 Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Murck H, Rosenbaum JF. A double-blind, randomized trial of St Johnʼs wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol 2005; 25: 441-447
    CrossrefPubMedGoogle Scholar
  • 97 Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St Johnʼs wort) in depression: A meta-analysis. J Affect Disord 2017; 210: 211-221
    CrossrefPubMedGoogle Scholar
  • 98 Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S, Mammì M, Palleria C, De Sarro G. Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phytother Res 2014; 28: 643-655
    CrossrefPubMedGoogle Scholar
  • 99 Kuo CH, Chou YC, Liao KC, Shieh CJ, Deng TS. Optimization of light intensity, temperature, and nutrients to enhance the bioactive content of hyperforin and rutin in St. Johnʼs wort. Molecules 2020; 25: 4256
    CrossrefPubMedGoogle Scholar
  • 100 Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action. J Cell Physiol 2019; 234: 8496-8508
    CrossrefPubMedGoogle Scholar
  • 101 Sarris J, Kavanagh DJ, Byrne G, Bone KM, Adams J, Deed G. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum . Psychopharmacology (Berl) 2009; 205: 399-407
    CrossrefPubMedGoogle Scholar
  • 102 Witte S, Loew D, Gaus W. Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with nonpsychotic anxiety disorders. Phytother Res 2005; 19: 183-188
    CrossrefPubMedGoogle Scholar
  • 103 Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry 2007; 61: 343-348
    CrossrefPubMedGoogle Scholar
  • 104 Dwyer AV, Whitten DL, Hawrelak JA. Herbal medicines, other than St. Johnʼs Wort, in the treatment of depression: a systematic review. Altern Med Rev 2011; 16: 40-49
    PubMedGoogle Scholar
  • 105 Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine 2015; 22: 394-399
    CrossrefPubMedGoogle Scholar
  • 106 Mao JJ, Li QS, Soeller I, Xie SX, Amsterdam JD. Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo-controlled trial. J Clin Trials 2014; 4: 170
    CrossrefPubMedGoogle Scholar
  • 107 Amsterdam JD, Panossian AG. Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine 2016; 23: 770-783
    CrossrefPubMedGoogle Scholar
  • 108 Akhondzadeh S, Kashani L, Fotouhi A, Jarvandi S, Mobaseri M, Moin M, Khani M, Jamshidi AH, Baghalian K, Taghizadeh M. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 123-127
    CrossrefPubMedGoogle Scholar
  • 109 Nikfarjam M, Rakhshan R, Ghaderi H. Comparison of effect of Lavandula officinalis and venlafaxine in treating depression: a double blind clinical trial. J Clin Diagn Res 2017; 11: KC01-KC04
    CrossrefPubMedGoogle Scholar
  • 110 Haybar H, Javid AZ, Haghighizadeh MH, Valizadeh E, Mohaghegh SM, Mohammadzadeh A. The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN 2018; 26: 47-52
    CrossrefPubMedGoogle Scholar
  • 111 Jeong HG, Ko YH, Oh SY, Han C, Kim T, Joe SH. Effect of Korean red ginseng as an adjuvant treatment for women with residual symptoms of major depression. Asia Pac Psychiatry 2015; 7: 330-336
    CrossrefPubMedGoogle Scholar
  • 112 Diaper A, Hindmarch I. A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults. Phytother Res 2004; 18: 831-836
    CrossrefPubMedGoogle Scholar
  • 113 Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001; 156: 481-484
    CrossrefPubMedGoogle Scholar
  • 114 Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2015; 232: 2427
    CrossrefPubMedGoogle Scholar
  • 115 Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo controlled randomized trial. Phytother Res 2008; 22: 1629-1634
    CrossrefPubMedGoogle Scholar
  • 116 Niu K, Hozawa A, Kuriyama S, Ebihara S, Guo H, Nakaya N, Ohmori-Matsuda K, Takahashi H, Masamune Y, Asada M, Sasaki S, Arai H, Awata S, Nagatomi R, Tsuji I. Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr 2009; 90: 1615-1622
    CrossrefPubMedGoogle Scholar
  • 117 Rothenberg DO, Zhang L. Mechanisms underlying the anti-depressive effects of regular tea consumption. Nutrients 2019; 11: E1361
    CrossrefPubMedGoogle Scholar
  • 118 Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 166-169
    CrossrefPubMedGoogle Scholar
  • 119 Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The improvement of sleep by oral intake of GABA and Apocynum venetum leaf extract. J Nutr Sci Vitaminol (Tokyo) 2015; 61: 182-187
    CrossrefPubMedGoogle Scholar
  • 120 Firoozabadi A, Zarshenas MM, Salehi A, Jahanbin S, Mohagheghzadeh A. Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression: a triple-blind randomized controlled trial study. J Evid Based Complement Altern Med 2015; 20: 94-97
    CrossrefPubMedGoogle Scholar
  • 121 Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, Farrell M, Degenhardt L. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry 2019; 6: 995-1010 Erratum in: Lancet Psychiatry 2020; 7: e3 Erratum in: Lancet Psychiatry 2020; 7: e3
    CrossrefPubMedGoogle Scholar
  • 122 Ferber SG, Namdar D, Hen-Shoval D, Eger G, Koltai H, Shoval G, Shbiro L, Weller A. The “entourage effect”: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders. Curr Neuropharmacol 2020; 18: 87-96
    CrossrefPubMedGoogle Scholar
  • 123 Bangratz M, Ait Abdellah S, Berlin A, Blondeau C, Guilbot A, Dubourdeaux M, Lemoine P. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. Neuropsychiatr Dis Treat 2018; 14: 1821-1829
    CrossrefPubMedGoogle Scholar
  • 124 Müller D, Pfeil T, von den Driesch V. Treating depression comorbid with anxiety – results of an open, practice-oriented study with St Johnʼs wort WS 5572 and valerian extract in high doses. Phytomedicine 2003; 10 (Suppl. 04) 25-30
    CrossrefPubMedGoogle Scholar
  • 125 Sarris J, Kavanagh DJ, Deed G, Bone KM. St. Johnʼs wort and Kava in treating major depressive disorder with comorbid anxiety: a randomised double-blind placebo-controlled pilot trial. Hum Psychopharmacol 2009; 24: 41-48
    CrossrefPubMedGoogle Scholar
  • 126 Zhang JJ, Gao TT, Wang Y, Wang JL, Guan W, Wang YJ, Wang CN, Liu JF, Jiang B. Andrographolide exerts significant antidepressant-like effects involving the hippocampal BDNF system in mice. Int J Neuropsychopharmacol 2019; 22: 585-600
    CrossrefPubMedGoogle Scholar
  • 127 Bartels C, Belz M, Vogelgsang J, Hessmann P, Bohlken J, Wiltfang J, Kosteve K. To be continued? long-term treatment effects of antidepressant drug classes and individual antidepressants on the risk of developing dementia: a German case-control study. J Clin Psychiatry 2020; 81: 19m13205
    CrossrefPubMedGoogle Scholar
  • 128 National Center for Complementary and Integrative Health (NCCIH). St. Johnʼs wort and depression: in depth. Accessed February 3, 2021 at: https://www.nccih.nih.gov/health/st-johns-wort-and-depression-in-depth
    PubMedGoogle Scholar
  • 129 Guy A, Brown M, Lewis S, Horowitz M. The ‘patient voice’: patients who experience antidepressant withdrawal symptoms are often dismissed or misdiagnosed with relapse or a new medical condition. Ther Adv Psychopharmacol 2020; 10: 1-15
    CrossrefPubMedGoogle Scholar
  • 130 Davies J, Read J. A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?. Addict Behav 2019; 97: 111-121
    CrossrefPubMedGoogle Scholar
  • 131 Jordan SA, Cunningham DG, Marles RJ. Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment. Toxicol Appl Pharmacol 2010; 243: 198-216
    CrossrefPubMedGoogle Scholar
  • 132 Pennington K, Focking M, McManus CA, Pariante CM, Dunn MJ, Cotter DR. A proteomic investigation of similarities between conventional and herbal antidepressant treatments. J Psychopharmacol 2009; 23: 520-530
    CrossrefPubMedGoogle Scholar