A Practical Procedure for Regioselective Bromination of Anilines

Abstract

A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na₂S₂O₈ in the presence of a catalytic amount of CuSO₄·5H₂O enabled regioselective bromination.

Key words

anilines - bromination - catalysis - copper - halides - halogenation - oxidation

Publication History

Received: 01 March 2021

Accepted after revision: 16 March 2021

Accepted Manuscript online:
16 March 2021

Article published online:
07 April 2021

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