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CC BY-NC-ND 4.0 · Endosc Int Open 2021; 09(06): E918-E924
DOI: 10.1055/a-1396-4236
Innovation forum

Development of a gel dedicated to gel immersion endoscopy

Tomonori Yano
1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
,
Atsushi Ohata
2   Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan
,
Yuji Hiraki
2   Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan
,
Makoto Tanaka
2   Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan
,
Satoshi Shinozaki
1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
,
Alan Kawarai Lefor
3   Department of Surgery, Jichi Medical University, Tochigi, Japan
,
Hironori Yamamoto
1   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
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Abstract

Backgrounds and study aims Gel immersion endoscopy is a novel technique to secure the visual field during endoscopy. The aim of this study was to develop a dedicated gel for this technique.

Methods To identify appropriate viscoelasticity and electrical conductivity, various gels were examined. Based on these results, the dedicated gel “OPF-203” was developed. Efficacy and safety of OPF-203 were evaluated in a porcine model.

Results  In vitro experiments showed that a viscosity of 230 to 1900 mPa·s, loss tangent (tanδ) ≤ 0.6, and hardness of 240 to 540 N/cm2 were suitable. Ex vivo experiments showed electrical conductivity ≤ 220 μS/cm is appropriate. In vivo experiments using gastrointestinal bleeding showed that OPF-203 provided clear visualization compared to water. After electrocoagulation of gastric mucosa in OPF-203, severe coagulative necrosis was not observed in the muscularis but limited to the mucosa.

Conclusions OPF-203 is useful for gel immersion endoscopy.



Publication History

Received: 08 January 2021

Accepted: 01 February 2021

Article published online:
27 May 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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