This study investigated the effects of marine phytoplankton supplementation on 1) perceived recovery and ground reaction forces in humans following a non-functional overreaching resistance-training program and 2) myogenic molecular markers associated with muscle cell recovery in a rat model. In the human trial, a 5-week resistance-training program with intentional overreaching on weeks 2 and 5 was implemented. Results indicate that marine phytoplankton prompted positive changes in perceived recovery at post-testing and, while both marine phytoplankton and placebo conditions demonstrated decreased peak and mean rate of force development following the overreaching weeks, placebo remained decreased at post-testing while marine phytoplankton returned to baseline levels. In the rat model, rats were divided into four conditions: (i) control, (ii) exercise, (iii) exercise + marine phytoplankton 2.55 mg·d-1, or (iv) exercise+marine phytoplankton 5.1 mg·d-1. Rats in exercising conditions performed treadmill exercise 5 d·wk-1 for 6 weeks. Marine phytoplankton in exercising rats increased positive and decrease negative myogenic factors regulating satellite cell proliferation. Taken together, marine phytoplankton improved perceptual and functional indices of exercise recovery in an overreaching human model and, mechanistically, this could be driven through cell cycle regulation and a potential to improve protein turnover.
4
Coutts A,
Reaburn P,
Piva TJ.
et al. Changes in selected biochemical, muscular strength, power, and endurance measures during deliberate overreaching and tapering in rugby league players. Int J Sports Med 2007; 28: 116-124
5
Kraemer WJ,
French DN,
Paxton NJ.
et al. Changes in exercise performance and hormonal concentrations over a big ten soccer season in starters and nonstarters. J Strength Cond Res 2004; 18: 121-128
6
Naessens G,
Chandler TJ,
Kibler WB.
et al. Clinical usefulness of nocturnal urinary noradrenaline excretion patterns in the follow-up of training processes in high-level soccer players. J Strength Cond Res 2000; 14: 125-131
8
Moore CA,
Fry AC.
Nonfunctional overreaching during off-season training for skill position players in collegiate American football. J Strength Cond Res 2007; 21: 793-800.
9
Coutts AJ,
Wallace LK,
Slattery KM.
Monitoring changes in performance, physiology, biochemistry, and psychology during overreaching and recovery in triathletes. Int J Sports Med 2007; 28: 125-134
10
Slattery K,
Bentley D,
Coutts AJ.
The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: Implications of antioxidant supplementation on physiological adaptation during intensified physical training. Sports Med 2015; 45: 453-471
11
Kadi F,
Charifi N,
Denis C.
et al. The behaviour of satellite cells in response to exercise: What have we learned from human studies?. Pflugers Arch 2005; 451: 319-327
15
Paulsen G,
Mikkelsen UR,
Raastad T.
et al. Leucocytes, cytokines and satellite cells: What role do they play in muscle damage and regeneration following eccentric exercise?. Exerc Immunol Rev 2012; 18: 42-97
16
Zammit PS.
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. Semin Cell Dev Biol 2017; 72: 19-32
17
Sharp MH,
Lowery RP,
Mobley CB.
et al. The effects of fortetropin supplementation on body composition, strength, and power in humans and mechanism of action in a rodent model. J Am Coll Nutr 2016; 35: 679-691
19
Maffiuletti NA,
Aagaard P,
Blazevich AJ.
et al. Rate of force development: Physiological and methodological considerations. Eur J Appl Physiol 2016; 116: 1091-1116
20
Hornsby WG,
Gentles JA,
MacDonald CJ.
et al. Maximum strength, rate of force development, jump height, and peak power alterations in weightlifters across five months of training. Sports (Basel) 2017; 5: 78
21
Sikorski EM,
Wilson JM,
Lowery RP.
et al. Changes in perceived recovery status scale following high-volume muscle damaging resistance exercise. J Strength Cond Res 2013; 27: 2079-2085
22
Laurent CM,
Green JM,
Bishop PA.
et al. A practical approach to monitoring recovery: Development of a perceived recovery status scale. J Strength Cond Res 2011; 25: 620-628
23
Graeff-Hönninger S,
Khajehei F.
The demand for superfoods: Consumers’ desire, production viability and bio-intelligent transition. In:
Piatti C,
Graeff-Hönninger S,
Khajehei F.
Food Tech Transitions: Reconnecting Agri-Food, Technology and Society. Springer International Publishing; 2019: 81-94
24
Sharp M,
Sahin K,
Stefan M.
et al. Phytoplankton supplementation lowers muscle damage and sustains performance across repeated exercise bouts in humans and improves antioxidant capacity in a mechanistic animal. Nutrients 2020; 12: 1990
26
Mazzetti SA,
Kraemer WJ,
Volek JS.
et al. The influence of direct supervision of resistance training on strength performance. Med Sci Sports Exerc 2000; 32: 1175-1184
27
Liu Y-F,
Chen H,
Yu L.
et al. Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol Learn Mem 2008; 90: 81-89
31
Harrison AJ,
Gaffney SD.
Effects of muscle damage on stretch-shortening cycle function and muscle stiffness control. J Strength Cond Res 2004; 18: 771-776
32
Wilson JM,
Flanagan EP.
The role of elastic energy in activities with high force and power requirements: A brief review. J Strength Cond Res 2008; 22: 1705-1715
33
Thorlund JB,
Michalsik LB,
Madsen K.
et al. Acute fatigue-induced changes in muscle mechanical properties and neuromuscular activity in elite handball players following a handball match. Scand J Med Sci Sports 2008; 18: 462-472
35
Johnston RD,
Gibson NV,
Twist C.
et al. Physiological responses to an intensified period of rugby league competition. J Strength Cond Res 2013; 27: 643-654
37
Calder KM,
Stashuk DW,
McLean L.
Physiological characteristics of motor units in the brachioradialis muscle across fatiguing low-level isometric contractions. J Electromyogr Kinesiol 2008; 18: 2-15
38
McManus L,
Hu X,
Rymer WZ.
et al. Changes in motor unit behavior following isometric fatigue of the first dorsal interosseous muscle. J Neurophysiol 2015; 113: 3186-3196
42
Zając A,
Chalimoniuk M,
Maszczyk A.
et al. Central and peripheral fatigue during resistance exercise – a critical review. J Hum Kinet 2015; 49: 159-169
43
Löscher WN,
Nordlund MM.
Central fatigue and motor cortical excitability during repeated shortening and lengthening actions. Muscle Nerve 2002; 25: 864-872
45
Alway SE,
Bennett BT,
Wilson JC.
et al. Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats. Exp Gerontol 2014; 50: 82-94
46
Jakeman JR,
Lambrick DM,
Wooley B.
et al. Effect of an acute dose of omega-3 fish oil following exercise-induced muscle damage. Eur J Appl Physiol 2017; 117: 575-582
47
Bhullar AS,
Putman CT,
Mazurak VC.
Potential role of omega-3 fatty acids on the myogenic program of satellite cells. Nutr Metab Insights 2016; 9: 1-10
48
Allen DL,
Hittel DS,
McPherron AC.
Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Med Sci Sports Exerc 2011; 43: 1828-1835
50
Joro R,
Uusitalo A,
DeRuisseau KC.
et al. Changes in cytokines, leptin, and IGF-1 levels in overtrained athletes during a prolonged recovery phase: A case-control study. J Sports Sci 2017; 35: 2342-2349
52
Andersson H,
Bøhn SK,
Raastad T.
et al. Differences in the inflammatory plasma cytokine response following two elite female soccer games separated by a 72-h recovery. Scand J Med Sci Sports 2010; 20: 740-747
55
Fahlman MM,
Engels H-J.
Mucosal IgA and URTI in American college football players: A year longitudinal study. Med Sci Sports Exerc 2005; 37: 374-380
56
Mackinnon LT,
Hooper S.
Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Int J Sports Med 1994; 15: S179-S183
58
Hayes LD,
Grace FM,
Baker JS.
et al. Exercise-induced responses in salivary testosterone, cortisol, and their ratios in men: a meta-analysis. Sports Med 2015; 45: 713-726
59
Anderson T,
Haake S,
Lane AR.
et al. CHANGES in resting salivary testosterone, cortisol and interleukin-6 as biomarkers of overtraining. Balt J Sport Health Sci 2016; 101: 2-7
60
Fry AC,
Kraemer WJ,
Stone MH.
et al. Endocrine and performance responses to high volume training and amino acid supplementation in elite junior weightlifters. Int J Sport Nutr 1993; 3: 306-322
61
Fry AC,
Kraemer WJ,
Stone MH.
et al. Endocrine responses to overreaching before and after 1 year of weightlifting. Can J Appl Physiol 1994; 19: 400-410
62
Häkkinen K,
Keskinen KL,
Alén M.
et al. Serum hormone concentrations during prolonged training in elite endurance-trained and strength-trained athletes. Eur J Appl Physiol 1989; 59: 233-238
63
Sands WA.
Chapter 18: Thinking sensibly about recovery. In: Strength and Conditioning for Sports Performance. Routledge; New York, NY: 2016. 451-483