Abstract
This review presents an account of the palladium-catalyzed functionalizations of alkenes and alkynes developed at the Laboratory of Catalysis and Organic Synthesis (LCSO). Starting from the intramolecular oxy- and aminoalkynylation of alkenes, tethered methods were then developed to functionalize allylic amines and alcohols, as well as propargylic amines. Finally, a new dynamic kinetic asymmetric transformation was developed based on the use of a ‘one-arm’ Trost-type ligand, giving access to enantiopure amino alcohols. Each section is a personal account by the researcher(s) who performed the work.
1 Introduction,
2 Oxy- and Aminoalkynylation of Olefins,
3 In Situ Tethering Strategies for the Synthesis of Vicinal Amino Alcohols and Diamines,
4 Carboamination of Allylic Alcohols,
5 Carbooxygenation of Propargylic Amines,
6 Enantioselective Carboetherification/Hydrogenation via a Catalytically Formed Chiral Auxiliary,
7 Conclusion
Key words
synthetic methods - palladium catalysis - alkynes - Trost ligands - DYKAT