Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus

Abstract

Irisin is a promising therapeutic target in patients with type 2 diabetes mellitus (T2DM), as studies have demonstrated that irisin can induce “browning“ of adipocytes and mitigate pro-inflammatory conditions. Sex-specific changes in irisin levels have been reported in a study involving healthy men and women following physical training. The present study aims to analyze the effects of an 8-week training intervention on circulating irisin levels in patients with T2DM and to find out whether the training responses differ between T2DM men and women. Twenty-nine overweight/obese T2DM patients (19 men, 10 women; age: 46–74 years; body mass index >25 kg/m²) participated in a combined moderate-intensity endurance/strength training program (3 times a week). The irisin levels of men and women did not differ significantly. The post-training irisin levels did not differ significantly from the pre-training values, and there was no interaction effect of sex. This study shows no training-induced (sex-specific) changes in circulating irisin levels in T2DM patients. Large-scale studies using other forms of training are needed to fully clarify whether basal irisin levels can be changed in T2DM men and/or women to counteract T2DM.

Key words

training - endurance - strength - inflammation - irisin - type 2 diabetes

Publication History

Received: 24 April 2020
Received: 22 September 2020

Accepted: 06 October 2020

Article published online:
11 November 2020

• References

• 1 Khan IU. Irisin: As a Therapeutic target for metabolic disorders. J Endocrinol Metab 2018; 8: 87-93
• 2 Zhang Y, Li R, Meng Y. et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 2014; 63: 514-525
• 3 Askari H, Rajani SF, Poorebrahim M. et al. A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: An introductory review. Pharmacol Res 2018; 129: 44-55
• 4 Liu J-J, Wong MDS, Toy WC. et al. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complicat 2013; 27: 365-369
• 5 Shoukry A, Shalaby SM, El-Arabi Bdeer S. et al. Circulating serum irisin levels in obesity and type 2 diabetes mellitus. IUBMB Life 2016; 68: 544-556
• 6 Huh JY, Siopi A, Mougios V. et al. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015; 100: E453-E457
• 7 Dünnwald T, Melmer A, Gatterer H. et al. Supervised short-term high-intensity training on plasma irisin concentrations in type 2 diabetic patients. Int J Sports Med 2019; 40: 158-164
• 8 Enteshary M, Esfarjani F, Reisi J. Comparison of the effects of two different intensities of combined training on irisin, betatrophin, and insulin levels in women with type 2 diabetes. Asian J Sports Med 2019; 10: e68943
• 9 Scalzo RL, Peltonen GL, Giordano GR. et al. Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PLoS One 2014; 9: e90696
• 10 Brinkmann C, Weh-Gray O, Brixius K. et al. Effects of exercising before breakfast on the health of T2DM patients-A randomized controlled trial. Scand J Med Sci Sports 2019; 29: 1930-1936
• 11 ADA: 3. Prevention or delay of type 2 diabetes: standards of medical care in diabetes-2020. Diabetes Care 2020; 43: S32-S36
• 12 Reynolds JM, Gordon TJ, Robergs RA. Prediction of one repetition maximum strength from multiple repetition maximum testing and anthropometry. J Strength Cond Res 2006; 20: 584-592
• 13 Archundia-Herrera C, Macias-Cervantes M, Ruiz-Muñoz B. et al. Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetol Metab Syndr 2017; 9: 101
• 14 Silvestrini A, Bruno C, Vergani E. et al. Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study. PLoS One 2019; 14: e0210320
• 15 Glass GV, Peckham PD, Sanders JR. Consequences of failure to meet assumptions underlying the fixed effects analyses of variance and covariance. Review of Educational Research 1972; 42: 237-288
• 16 Weston KS, Wisløff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: A systematic review and meta-analysis. Br J Sports Med 2014; 48: 1227-1234
• 17 Safarimosavi S, Mohebbi H, Rohani H. High-intensity interval vs. continuous endurance training: Preventive effects on hormonal changes and physiological adaptations in prediabetes patients. J Strength Cond Res 2018;
• 18 Pardo M, Crujeiras AB, Amil M. et al. Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol 2014; 2014: 857270
• 19 Stengel A, Hofmann T, Goebel-Stengel M. et al. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides 2013; 39: 125-130
• 20 Roca-Rivada A, Castelao C, Senin LL. et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 2013; 8: e60563
• 21 Kim H-J, Lee H-J, So B. et al. Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: A pilot study. Physiol Res 2016; 65: 271-279
• 22 Haddad HE, Sedrak H, Naguib M. et al. Irisin level in type 2 diabetic patients and its relation to glycemic control and diabetic complications. Int J Diabetes Dev Ctries 2019; 39: 641-646
• 23 Rana KS, Pararasa C, Afzal I. et al. Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels. Cardiovasc Diabetol 2017; 16: 147
• 24 Qiu S, Cai X, Yin H. et al. Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis. Metabolism 2016; 65: 825-834
• 25 Zügel M, Qiu S, Laszlo R. et al. The role of sex, adiposity, and gonadectomy in the regulation of irisin secretion. Endocrine 2016; 54: 101-110
• 26 Huh JY, Panagiotou G, Mougios V. et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61: 1725-1738
• 27 Sanchis-Gomar F, Alis R, Pareja-Galeano H. et al. Inconsistency in circulating irisin levels: what is really happening?. Horm Metab Res 2014; 46: 591-596
• 28 Ebert T, Kralisch S, Wurst U. et al. Association of metabolic parameters and rs76344 in FNDC5 with serum irisin concentrations. Int J Obes 2016; 40: 260-265
• 29 Perakakis N, Triantafyllou GA, Fernandez-Real JM. et al. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol 2017; 13: 324-337