Onkologische Erkrankungen im Alter

Mehr als die Hälfte der Menschen mit einer neu diagnostizierten onkologischen Erkrankung ist über 70 Jahre alt. In dieser Altersgruppe ist die Tumorbehandlung mit anderen Herausforderungen verbunden als bei Betroffenen im jüngeren Lebensalter. Dieser Beitrag fasst dazu den gegenwärtigen Erkenntnisstand zusammen und beschreibt die Besonderheiten von Diagnostik und Therapie onkologischer Erkrankungen im Alter.

Abstract

A majority of patients with newly diagnosed malignant disease are 70 years old or older. Frailty – i. e. increased vulnerability towards stressors at older age – is a major challenge during the oncological work-up and treatment in the elderly. Therefore, older cancer patients should receive a systematic assessment of frailty by use of standard tools. Assessment results should be carefully considered during oncological treatment decisions, e. g. in interdisciplinary tumor conferences. Moreover, they are prerequisite to initiate geriatric co-management for which there is emerging new evidence. Advances in tumor surgery and irradiation as well as personalized precision medicine with novel targeted drugs have facilitated the treatment of cancer even in old age and frailty. However, patients with such characteristics are at increased risk of complications compared to younger subjects. Physicians and medical staff involved in treatment must therefore co-operate well. This article provides an overview of the current evidence and highlights key aspects of diagnosis and treatment of malignant diseases in the elderly.

Schlüsselwörter

Frailty - geriatrisches Assessment - Chemotherapie - Präzisionsmedizin

Key words

frailty - geriatric assessment - chemotherapy - precision medicine

Publikationsverlauf

Artikel online veröffentlicht:
26. August 2021

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