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DOI: 10.1055/a-1220-8737
Wie beeinflussen Parasiten das Verhalten ihres Wirts? Die parasitäre Manipulationshypothese
Behavioural Changes Caused by Parasites: The Parasite Manipulation Hypothesis![](https://www.thieme-connect.de/media/dmw/202025/lookinside/thumbnails/dmw-12208737_10-1055-a-1220-8737-1.jpg)
Parasiten sind zur Erhaltung der Art auf die Übertragung von einem Wirt zum nächsten angewiesen. Wie ausgeklügelt Parasiten ihren Wirt benutzen und ob eine Verhaltensänderung des Wirts auf einer adaptiven Manipulation im Sinne einer Ursachen-Wirkungs-Beziehung beruht, erörtert dieser Beitrag.
Abstract
Bacteria, archaeae, fungi and viruses of the intestinal microbiome play an important role as symbionts in the complex human ecosystem. Parasites, which account for about 40 % of the earth’s biodiversity, depend on hosts to complete their life cycle. This article explains how they use them and which signalling pathways play a role in this, using toxoplasmosis and malaria as examples. The parasitic manipulation hypothesis is based on impressive observations in the wild and under laboratory conditions, especially in invertebrates. For the assumption of an adaptive manipulation, every step from the genotype, the translated messenger, and its source via the used signalling pathways to the altered host behaviour must be proven. The assumption of an adaptive manipulation of humans by T. gondii in the sense of a cause-effect relationship is not proven. Alternative explanations include the inflammatory and immunological processes on the host side, which change the neuronal signal transduction as concomitant symptoms of an infection. Even without confirmation of parasitic manipulation in humans, it could be worthwhile to further investigate the observed associations in order to develop new possibilities for diagnosis and therapy, e. g. for schizophrenia.
Publication History
Article published online:
16 December 2020
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Literatur
- 1 Will I, Biplabendu D, Thienthanh T. et al Genetic underpinnings of host manipulation by Ophiocordyceps as revealed by comparative transcriptomics. G3 (Bethesda) 2020; 10: 2275-2296 . doi:10.1534/g3.120.401290
- 2 Martin-Vega D, Garbout A, Ahmed F. et al 3D virtual histology at the host/parasite interface: visualisation of the master manipulator, Dicrocoelium dendriticum, in the brain of its ant host. Sci Rep 2018; 8: 8587 . doi:10.1038/s41598-018-26977-2
- 3 Thomas F, Schmidt-Rhaesa A, Martin G. et al Do hairworms (Nematomorpha) manipulate the water seeking behaviour of their terrestrial hosts?. J Evol Biol 2002; 15: 356-361
- 4 Libersat F, Gal R. What can parasitoid wasps teach us about decision-making in insects?. J Exp Biol 2013; 216: 47-55 . doi:10.1242/jeb.073999
- 5 Hueffer K, Khatri S, Rideout S. et al Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. Sci Rep 2017; 7: 12818 . doi:10.1038/s41598-017-12726-4
- 6 Tyebji S, Seizova S, Hannan AJ. et al Toxoplasmosis: A pathway to neuropsychiatric disorders. Neurosci Biobehav Rev 2019; 96: 72-92 . doi:10.1016/j.neubiorev.2018.11.012
- 7 Vyas A, Kim SK, Giacomini N. et al Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors. Proc Natl Acad Sci USA 2007; 104: 6442-6447 . doi:10.1073/pnas.0608310104
- 8 Hari SA, Vyas A. Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala. Mol Ecol 2014; 23: 6114-6122 . doi:10.1111/mec.12888
- 9 Poirotte C, Kappeler PM, Ngoubangoye B. et al Morbid attraction to leopard urine in Toxoplasma-infected chimpanzees. Curr Biol 2016; 26: R98-R99 . doi:10.1016/j.cub.2015.12.020
- 10 Martin HL, Alsaady I, Howell G. et al Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells. Neuroscience 2015; 306: 50-62 . doi:10.1016/j.neuroscience.2015.08.005
- 11 Alsaady I, Tedford E, Alsaad M. et al Downregulation of the central noradrenergic system by Toxoplasma gondii infection. Infect Immun 2019; 87: e00789-18 . doi:10.1128/IAI.00789-18
- 12 Flegr J, Lenochova P, Hodny Z. et al Fatal attraction phenomenon in humans: cat odour attractiveness increased for toxoplasma-infected men while decreased for infected women. PLoS Negl Trop Dis 2011; 5: e1389 . doi:10.1371/journal.pntd.001389
- 13 Lindova J, Kubena AA, Sturcova H. et al Pattern of money allocation in experimental games supports the stress hypothesis of gender differences in Toxoplasma gondii-induced behavioural changes. Folia Parasitol (Praha) 2010; 57: 136-142
- 14 Ling VJ, Lester D, Mortensen PB. et al Toxoplasma gondii seropositivity and suicide rates in women. J Nerv Ment Dis 2011; 199: 440-444 . doi:10.1097/NMD.0b013e318221416e
- 15 Sutterland AL, Kuin A, Kuiper B. et al Driving us mad: the association of Toxoplasma gondii with suicide attempts and traffic accidents – a systematic review and meta-analysis. Psychol Med 2019; 49: 1608-1623 . doi:10.1017/S0033291719000813
- 16 Samojłowicz D, Twarowska-Małczyńska J, Borowska-Solonynko A. et al Presence of Toxoplasma gondii infection in brain as a potential cause of risky behavior: a report of 102 autopsy cases. Eur J Clin Microbiol Infect Dis 2019; 38: 305-317 . doi:10.1007/s10096-018-3427-z
- 17 Stock AK, Dajkic D, Köhling HL. et al Humans with latent toxoplasmosis display altered reward modulation of cognitive control. Sci Rep 2017; 7: 10170 . doi:10.1038/s41598-017-10926-6
- 18 Berrett AN, Gale SD, Erickson LD. et al Toxoplasma gondii seropositivity and substance use in US adults. Folia Parasitol (Praha) 2018; 65: 011 . doi:10.14411/fp.2018.011
- 19 Sutterland AL, Fond G, Kuin A. et al Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand 2015; 132: 161-179 . doi:10.1111/acps.12423
- 20 Herbison REH. Lessons in mind control: trends in research on the molecular mechanisms behind parasite-host behavioral manipulation. Front Ecol Evol 2017; 5: 102 . doi:10.3389/fevo.2017.00102
- 21 Hafer N. Conflicts over host manipulation between different parasites and pathogens: investigating the ecological and medical consequences. Bioassays 2016; 38: 1027-1037 . doi:10.1002/bies.201600060
- 22 Busula AO, Bousema T, Mweresa CK. et al Gametocytemia and attractiveness of Plasmodium falciparum-infected Kenyan children to Anopheles gambiae mosquitoes. J Infect Dis 2017; 216: 291-295 . doi:10.1093/infdis/jix214
- 23 Emami SN, Lindberg BG, Hua S. et al A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection. Science 2017; 355: 1076-1080 . doi:10.1126/science.aah4563
- 24 Reiber C, Shattuck EC, Fiore S. et al Change in human social behavior in response to a common vaccine. Ann Epidemiol 2010; 20: 729-733 . doi:10.1016/j.annepidem.2010.06.014
- 25 Severance EG, Dickerson FB, Viscidi RP. et al Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms. Schizophr Bull 2011; 37: 101-107 . doi:10.1093/schbul/sbp052