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DOI: 10.1055/a-1207-0557
Hat die Ernährung einen Einfluss auf die Endometriose?
Artikel in mehreren Sprachen: English | deutschZusammenfassung
Die Endometriose ist eine hormonabhängige, chronisch entzündliche Erkrankung der Frau im gebärfähigen Alter. Die Ätiologie und Pathogenese der Endometriose sind bis heute nicht abschließend geklärt. Für andere Krankheiten, z. B. sog. „lifestyle diseases“ ist ein Zusammenhang zwischen Ernährung und Pathogenese bereits erforscht und belegt. Hinsichtlich dieser Erkenntnisse taucht immer wieder die Frage auf, ob und wie eine gezielte Ernährung und Lebensweise auch die Krankheitsentstehung und den Verlauf einer Endometriose beeinflussen können. Ziel dieser Übersichtsarbeit ist es, die aktuelle Datenlage zu ordnen und herauszuarbeiten, welchen Einfluss die Ernährung auf die Entstehung der Endometriose bzw. auf eine bereits manifestierte Erkrankung haben könnte. Für eine gezielte, wissenschaftlich fundierte Empfehlung oder einen detaillierten Ernährungsplan reichen die vorliegenden Studienergebnisse bislang nicht aus. Zusammenfassend lässt sich festhalten: Ein positiver Effekt auf die Symptome einer Endometriose (insbesondere der Dysmenorrhö) wird Fischölkapseln in Kombination mit Vitamin B12 zugesprochen. Negativ wirken sich Alkohol sowie die gesteigerte Aufnahme von rotem Fleisch und Transfetten aus. Die Ergebnisse der aufgeführten Studien im Hinblick auf Gemüse und Obst, Milchprodukte, ungesättigte Fettsäuren, Ballaststoffe, Sojaprodukte sowie Kaffee sind nicht eindeutig. Es gelten daher die allgemeinen Empfehlungen zu einer ausgewogenen und abwechslungsreichen Ernährung entsprechend den Regeln der Deutschen Gesellschaft für Ernährung e. V. sowie der Verzicht auf Alkohol. Um konkretere Empfehlungen herleiten zu können, bedarf es weiterer Studien, die den Einfluss der Ernährung auf die Endometriose erforschen.
Publikationsverlauf
Eingereicht: 05. Mai 2020
Angenommen: 24. Juni 2020
Artikel online veröffentlicht:
08. Februar 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References/Literatur
- 1 Burghaus S, Hildebrandt T, Fahlbusch C. et al. Standards Used by a Clinical and Scientific Endometriosis Center for the Diagnosis and Therapy of Patients with Endometriosis. Geburtshilfe Frauenheilkd 2019; 79: 487-497
- 2 Vinatier D, Orazi G, Cosson M. et al. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol 2001; 96: 21-34
- 3 Giudice LC. Endometriosis. N Engl J Med 2010; 362: 2389-2398
- 4 Donnez J, Squifflet J, Casanas-Roux F. et al. Typical and subtle atypical presentations of endometriosis. Obstet Gynecol Clin North Am 2003; 30: 83-93
- 5 Schweppe K-W. Endometriose: Ist eine Prophylaxe möglich?. Gynäkologe 2018; 59: 754-758
- 6 Czyzyk A, Podfigurna A, Szeliga A. et al. Update on endometriosis pathogenesis. Minerva Ginecol 2017; 69: 447-461
- 7 Missmer SA, Chavarro JE, Malspeis S. et al. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod Oxf Engl 2010; 25: 1528-1535
- 8 Bulletti C, Coccia ME, Battistoni S. et al. Endometriosis and infertility. J Assist Reprod Genet 2010; 27: 441-447
- 9 Jurkiewicz-Przondziono J, Lemm M, Kwiatkowska-Pamuła A. et al. Influence of diet on the risk of developing endometriosis. Ginekol Pol 2017; 88: 96-102
- 10 Dyson MT, Bulun SE. Cutting SRC-1 down to size in endometriosis. Nat Med 2012; 18: 1016-1018
- 11 Ulrich U. et al. Leitlinie für die Diagnostik und Therapie der Endometriose. Online (last access: 07.11.2019): https://www.endometriose-vereinigung.de/files/endometriose/reiter endometriose/Leitlinie_Diagnostik_Therapie_Endometriose.pdf
- 12 Hudelist G, Fritzer N, Thomas A. et al. Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod Oxf Engl 2012; 27: 3412-3416
- 13 Simoens S, Dunselman G, Dirksen C. et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod Oxf Engl 2012; 27: 1292-1299
- 14 Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 2009; 280: 529-538
- 15 Taniguchi F. New knowledge and insights about the malignant transformation of endometriosis. J Obstet Gynaecol Res 2017; 43: 1093-1100 doi:10.1111/jog.13372
- 16 Darling AM, Chavarro JE, Malspeis S. et al. A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis. J Endometr 2013; 5: 17-26
- 17 Kaiser B, Korell M. Endometriose und Ernährung. Müller & Steinicke KG Verlag; 2017
- 18 McCabe DC, Caudill MA. DNA methylation, genomic silencing, and links to nutrition and cancer. Nutr Rev 2005; 63: 183-195
- 19 Kunisue T, Chen Z, Buck Louis GM. et al. Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. Environ Sci Technol 2012; 46: 4624-4632
- 20 Parazzini F, Chiaffarino F, Surace M. et al. Selected food intake and risk of endometriosis. Hum Reprod Oxf Engl 2004; 19: 1755-1759
- 21 Trabert B, Peters U, De Roos AJ. et al. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr 2011; 105: 459-467
- 22 Harris HR, Eke AC, Chavarro JE. et al. Fruit and vegetable consumption and risk of endometriosis. Hum Reprod Oxf Engl 2018; 33: 715-727
- 23 Parazzini F, Viganò P, Candiani M. et al. Diet and endometriosis risk: a literature review. Reprod Biomed Online 2013; 26: 323-336
- 24 Britton JA, Westhoff C, Howe G. et al. Diet and benign ovarian tumors (United States). Cancer Causes Control 2000; 11: 389-401
- 25 Savaris AL, do Amaral VF. Nutrient intake, anthropometric data and correlations with the systemic antioxidant capacity of women with pelvic endometriosis. Eur J Obstet Gynecol Reprod Biol 2011; 158: 314-318
- 26 Deutsche Gesellschaft für Ernährung e. V.. 10 Regeln der DGE. Online (last access: 07.11.2019): https://www.dge.de/fileadmin/public/doc/fm/10-Regeln-der-DGE.pdf
- 27 Heilier J-F, Donnez J, Nackers F. et al. Environmental and host-associated risk factors in endometriosis and deep endometriotic nodules: a matched case-control study. Environ Res 2007; 103: 121-129
- 28 Yamamoto A, Harris HR, Vitonis AF. et al. A prospective cohort study of meat and fish consumption and endometriosis risk. Am J Obstet Gynecol 2018; 219: 178.e1-178.e10
- 29 Capobianco A, Monno A, Cottone L. et al. Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol 2011; 179: 2651-2659
- 30 Owen RW, Giacosa A, Hull WE. et al. The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer Oxf Engl 1990 2000; 36: 1235-1247
- 31 Psaltopoulou T, Kosti RI, Haidopoulos D. et al. Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies. Lipids Health Dis 2011; 10: 127
- 32 Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 2003; 38: 343-352
- 33 Gazvani MR, Smith L, Haggarty P. et al. High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis. Fertil Steril 2001; 76: 717-722
- 34 Hopeman MM, Riley JK, Frolova AI. et al. Serum Polyunsaturated Fatty Acids and Endometriosis. Reprod Sci 2015; 22: 1083-1087
- 35 Khanaki K, Nouri M, Ardekani AM. et al. Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids. Iran Biomed J 2012; 16: 38-43
- 36 Correale J, Ysrraelit MC, Gaitán MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain J Neurol 2009; 132: 1146-1160
- 37 Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010; 39: 365-379
- 38 Chambers ES, Hawrylowicz CM. The impact of vitamin D on regulatory T cells. Curr Allergy Asthma Rep 2011; 11: 29-36
- 39 Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease?: a systematic review. Semin Arthritis Rheum 2011; 40: 512-531.e8
- 40 Harris HR, Chavarro JE, Malspeis S. et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177: 420-430
- 41 Altura BT, Altura BM. Endothelium-dependent relaxation in coronary arteries requires magnesium ions. Br J Pharmacol 1987; 91: 449-451
- 42 DʼAngelo EK, Singer HA, Rembold CM. Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+ without changing intracellular Mg2+. J Clin Invest 1992; 89: 1988-1994
- 43 Nagamani M, Stuart CA. Specific binding and growth-promoting activity of insulin in endometrial cancer cells in culture. Am J Obstet Gynecol 1998; 179: 6-12
- 44 Kazer RR. Insulin resistance, insulin-like growth factor I and breast cancer: A hypothesis. Int J Cancer 1995; 62: 403-406
- 45 Friberg E, Wallin A, Wolk A. Sucrose, high-sugar foods, and risk of endometrial cancer–a population-based cohort study. Cancer Epidemiol Biomarkers Prev 2011; 20: 1831-1837
- 46 Andres S, Abraham K, Appel KE. et al. Risks and benefits of dietary isoflavones for cancer. Crit Rev Toxicol 2011; 41: 463-506
- 47 Tsuchiya M, Miura T, Hanaoka T. et al. Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism. Epidemiol Camb Mass 2007; 18: 402-408
- 48 Yavuz E, Oktem M, Esinler I. et al. Genistein causes regression of endometriotic implants in the rat model. Fertil Steril 2007; 88: 1129-1134
- 49 Chen Y, Chen C, Shi S. et al. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. Reprod Sci Thousand Oaks Calif 2011; 18: 886-891
- 50 Lucero J, Harlow BL, Barbieri RL. et al. Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril 2001; 76: 723-729
- 51 Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996; 144: 642-644
- 52 Homan GF, Davies M, Norman R. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update 2007; 13: 209-223
- 53 Chiaffarino F, Bravi F, Cipriani S. et al. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur J Nutr 2014; 53: 1573-1579
- 54 Seitz HK, Pelucchi C, Bagnardi V. et al. Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012. Alcohol Alcohol 2012; 47: 204-212
- 55 Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 2001; 286: 2143-2151
- 56 Secretan B, Straif K, Baan R. et al. WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens–Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009; 10: 1033-1034
- 57 Fernandez SV. Estrogen, alcohol consumption, and breast cancer. Alcohol Clin Exp Res 2011; 35: 389-391
- 58 Di Giuseppe D, Alfredsson L, Bottai M. et al. Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study. BMJ 2012; 345: e4230
- 59 Cassano N, Vestita M, Apruzzi D. et al. Alcohol, psoriasis, liver disease, and anti-psoriasis drugs. Int J Dermatol 2011; 50: 1323-1331
- 60 Parazzini F, Cipriani S, Bravi F. et al. A metaanalysis on alcohol consumption and risk of endometriosis. Am J Obstet Gynecol 2013; 209: 106.e1-106.e10
- 61 Liu YK. Effects of alcohol on granulocytes and lymphocytes. Semin Hematol 1980; 17: 130-136
- 62 Imperia PS, Chikkappa G, Phillips PG. Mechanism of inhibition of granulopoiesis by ethanol. Proc Soc Exp Biol Med 1984; 175: 219-225
- 63 Ockenfels HM, Keim-Maas C, Funk R. et al. Ethanol enhances the IFN-gamma, TGF-alpha and IL-6 secretion in psoriatic co-cultures. Br J Dermatol 1996; 135: 746-751
- 64 Crews FT, Bechara R, Brown LA. et al. Cytokines and alcohol. Alcohol Clin Exp Res 2006; 30: 720-730
- 65 Serwin AB, Sokolowska M, Chodynicka B. Tumour necrosis factor alpha (TNF-alpha)-converting enzyme (TACE) and soluble TNF-alpha receptor type 1 in psoriasis patients treated with narrowband ultraviolet B. Photodermatol Photoimmunol Photomed 2007; 23: 130-134
- 66 Sepulcri R de P, do Amaral VF. Depressive symptoms, anxiety, and quality of life in women with pelvic endometriosis. Eur J Obstet Gynecol Reprod Biol 2009; 142: 53-56
- 67 Davis L, Uezato A, Newell JM. et al. Major depression and comorbid substance use disorders. Curr Opin Psychiatry 2008; 21: 14-18
- 68 Hansen SO, Knudsen UB. Endometriosis, dysmenorrhoea and diet. Eur J Obstet Gynecol Reprod Biol 2013; 169: 162-171
- 69 Deutch B. Menstrual pain in Danish women correlated with low n-3 polyunsaturated fatty acid intake. Eur J Clin Nutr 1995; 49: 508-516
- 70 Sesti F, Pietropolli A, Capozzolo T. et al. Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III–IV. A randomized comparative trial. Fertil Steril 2007; 88: 1541-1547