Subscribe to RSS
DOI: 10.1055/a-1197-4475
Listeriose beim Chinchilla als Bestandsproblem – ein Fallbericht
Listeriosis in a chinchilla herd – a case report![](https://www.thieme-connect.de/media/10.1055-s-00034911/202004/lookinside/thumbnails/10-1055-a-1197-4475-1.jpg)
Zusammenfassung
Ein 6 Jahre altes, weibliches Chinchilla aus einer kleinen Kolonie in Wohnungshaltung wurde wegen Lethargie und Anorexie vorgestellt. Neben einer durch Harnanalyse diagnostizierten Ketoazidose bestand Verdacht auf Sepsis. Die symptomatische Therapie erbrachte keine Besserung und das Tier wurde euthanasiert. Anhand von histopathologischen, immunhistologischen und bakteriologischen Untersuchungen wurde eine Infektion mit Listeria monocytogenes diagnostiziert. Der Erreger war auch im Kot von 2 weiteren Tieren im Bestand nachweisbar, von denen eines starb und das andere überlebte. Der Bestand wurde antibiotisch nach Resistenztest behandelt. Am Ende der 2-monatigen Beobachtungszeit lebten noch 3 von 7 Chinchillas. Der Fallbericht beschreibt den Nachweis der Listeriose bei als Heimtier gehaltenen Chinchillas in reiner Wohnungshaltung, die Pathogenese der Erkrankung, die Möglichkeiten der Diagnostik sowie die Therapie.
Abstract
A 6-year-old female chinchilla from a small colony in residential housing was presented due to lethargy and anorexia. Besides a ketoacidosis diagnosed by urinalysis, sepsis was suspected. Symptomatic treatment did not lead to any improvement, in consequence the animal was euthanized. On the basis of histopathological, immunohistological, and bacteriological examinations an infection with Listeria monocytogenes was diagnosed. The pathogen was also detectable in the feces of 2 other animals of the herd, one of which died and the other survived. The herd was treated with antibiotics following microbiologic sensitivity testing. At the end of the 2-month observation period, 3 out of 7 chinchillas were still alive. The presented case report describes the detection of listeriosis in pet chinchillas, the pathogenesis of the disease, as well as the diagnostic options and therapy.
Publication History
Received: 18 December 2019
Accepted: 06 April 2020
Article published online:
21 August 2020
© Georg Thieme Verlag KG
Stuttgart · New York
-
Literatur
- 1 CLSI. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals; Informational Supplement; CLSI document M31-S1. Wayne, Pa, USA: Clinical and Laboratory Standards Institute; 2002
- 2 CLSI. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals: Approved Standard; CLSI document M31-A2. 2nd ed.. Wayne, Pa, USA: Clinical and Laboratory Standards Institute; 2004
- 3 Wikler MA. Performance standards for antimicrobial susceptibility testing fourteenth informational supplement. Wayne, Pa: NCCLS; 2004
- 4 Selbitz H-J, Truyen U, Valentin-Weigand P. Hrsg. Tiermedizinische Mikrobiologie, Infektions- und Seuchenlehre. 10. Aufl.. Stuttgart: Enke; 2015
- 5 Kimpe A, Decostere A, Hermans K. et al. Isolation of Listeria ivanovii from a septicaemic chinchilla (Chinchilla lanigera). Vet Rec 2004; 154: 791-792 DOI: doi:10.1136/vr.154.25.791.
- 6 Laureyns J, Moyaert H, Werbrouck H. et al. Pustular dermatitis by Listeria monocytogenes after the assisted delivery of a dead calf. Vlaams Diergeneesk Tijdschr 2008; 77: 29-34
- 7 OIE – World Organisation for Animal Health. Manual of diagnostic tests and vaccines for terrestrial animals. 7th ed.. Paris: OIE; 2012 https://www.oie.int/doc/ged/D12009.PDF Stand: 01.03.2020
- 8 Gray M, Killinger A. Listeria monocytogenes and Listeric Infections. Bacteriol Rev 1966; 30 (02) 309-382
- 9 Buchanan RL, Gorris LGM, Hayman MM. et al. A review of Listeria monocytogenes: An update on outbreaks, virulence, dose-response, ecology, and risk assessments. Food Control 2017; 75: 1-13 DOI: doi:10.1016/j.foodcont.2016.12.016.
- 10 Finley GG, Long JR. An epizootic of listeriosis in chinchillas. Can Vet J 1977; 18: 164-167
- 11 Wilkerson MJ, Melendy A, Stauber E. An outbreak of listeriosis in a breeding colony of chinchillas. J Vet Diagn Invest 1997; 9: 320-323 doi:10.1177/104063879700900318
- 12 Kirinus J, Krewer C, Zeni D. et al. Outbreak of systemic listeriosis in chinchillas. Ciência Rural 2010; 40: 686-689
- 13 Sabocanec R, Culjak K, Ramadan K. et al. Incidence of listeriosis in farm chinchillas (Chinchilla laniger) in Croatia. Vet Arhiv 2000; 70: 159-167
- 14 Furowicz A, Broda D, Czernomysy-Furowicz D. Therapeutic value of immunostimulation with Propionibacterium acnes in the treatment of Listeriosis in chinchilla. Medycyna Weterynaryjna 1989; 45 (05) 289-291
- 15 [Anonym]. Listeria monocytogenes, Chinchilla. In: Proceedings of the Veterinary Pathology Service 2008–2009. Department of Defense, Veterinary Pathology Residency. 93-95 https://www.askjpc.org/wsco/wsc/wsc08/WSCProceedings2008–2009.pdf Stand: 01.03.2020
- 16 [Anonym]. Listeria monocytogenes, Chinchilla. In: Proceedings of the Veterinary Pathology Service 2016–2017. Department of Defense, Veterinary Pathology Residency. 38-42 https://www.askjpc.org/wsco/wsc/wsc16/WSCProceedings2016–2017.pdf Stand: 01.03.2020
- 17 Ataseven L, Yardımcı H. Listeria monocytogenes isolation from a chinchilla (Chinchilla laniger). In: AVKAE Derg 2012; 2: 22-25
- 18 Leader RW, Holte RJ. Studies on three outbreaks of listeriosis in chinchillas. Cornell Vet 1955; 45: 78-84
- 19 MacDonald DW, Wilton GS, Howell J. et al. Listeria monocytogenes isolations in Alberta 1951–1970. Can Vet J 1972; 13: 69-71
- 20 Turner PV, Brash ML, Smith DA. Pathology of Small Mammal Pets. Hoboken, NJ, USA: John Wiley & Sons; 2017. http://doi.wiley.com/10.1002/9781118969601 Stand: 14.09.2019
- 21 Hoelzer K, Pouillot R, Dennis S. Animal models of listeriosis: a comparative review of the current state of the art and lessons learned. Vet Res 2012; 43: 18 doi:10.1186/1297–9716–43–18
- 22 Pritchard JC, Jacob ME, Ward TJ. et al. Listeria monocytogenes septicemia in an immunocompromised dog. Vet Clin Pathol 2016; 45: 254-259 DOI: 10.1111/vcp.12363.
- 23 Hof H, Nichterlein T, Kretschmar M. Management of listeriosis. Clin Microbiol Rev 1997; 10: 345-357
- 24 Melton-Witt JA, Rafelski SM, Portnoy DA. et al. Oral Infection with Signature-Tagged Listeria monocytogenes Reveals Organ-Specific Growth and Dissemination Routes in Guinea Pigs. Infect Immun 2012; 80: 720-732 DOI: 10.1128/IAI.05958–11.
- 25 Hein J. Urinuntersuchung beim Kleinsäuger – so einfach und doch so aussagekräftig. kleintier konkret 2015; 18: 30-35 doi:10.1055/s-0035–1547402
- 26 Lemoy M-JMF, Lopes DA, Reader JR. et al. Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta). Comp Med 2012; 62: 443-447
- 27 Hof H. Chemotherapy of Listeria infections. GMS Infectious Diseases. 1:Doc06; ISSN 2195–8831 2013. Im Internet: http://www.egms.de/en/journals/id/2013–1/id000006.shtml Stand: 14.09.2019
- 28 Hein J. Durchfallerkrankungen bei Kleinsäugern: Ursache, Diagnostik, Therapie. Hannover: Schlütersche; 2017
- 29 Hansen S. Untersuchungen zum Ca-Stoffwechsel sowie zur Zahnlängenentwicklung und -zusammensetzung von Chinchillas bei Variation der Ca-Zufuhr und des Angebots von Nagematerial. 2012 https://d-nb.info/1024434818/34 Stand: 13.10.2019
- 30 CliniPharm Clinitox, Chloramphenicol – Pharmakologie. https://www.vetpharm.uzh.ch/wir/00000005/6757_02.htm Stand: 13.10.2019
- 31 Plumb DC. Plumb’s Veterinary Drug Handbook. 9th ed.. Stockholm, Wisconsin: Pharma Vet Inc; 2018
- 32 Pallo-Zimmerman LM, Byron JK, Graves TK. Fluoroquinolones: then and now. Compend Contin Educ Vet 2010; 32: E1-9 quiz E9
- 33 López-Cadenas C, Sierra-Vega M, García-Vieitez JJ. et al. Enrofloxacin: pharmacokinetics and metabolism in domestic animal species. Curr Drug Metab 2013; 14: 1042-1058
- 34 Crespo R, Garner MM, Hopkins SG. et al. Outbreak of Listeria monocytogenes in an urban poultry flock. BMC Vet Res 2013; 9: 204 DOI: 10.1186/1746–6148–9-204.
- 35 Prieto M, Martínez C, Aguerre L. et al. Antibiotic susceptibility of Listeria monocytogenes in Argentina. Enferm Infecc Microbiol Clin 2016; 34: 91-95 DOI: 10.1016/j.eimc.2015.03.007.
- 36 Blanot S, Boumaila C, Berche P. Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis. J Antimicrob Chemother 1999; 44: 565-568 doi:10.1093/jac/44.4.565
- 37 Becattini S, Littmann ER, Carter RA. et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J Exp Med 2017; 214: 1973-1989 DOI: 10.1084/jem.20170495.
- 38 Lauvau G. Priming of Memory But Not Effector CD8 T Cells by a Killed Bacterial Vaccine. Science 2001; 294: 1735-1739 doi:10.1126/science.1064571
- 39 Kiderlen AF, Kaufmann SH, Lohmann-Matthes ML. Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon. Eur J Immunol 1984; 14: 964-967 doi:10.1002/eji.1830141019
- 40 Nomoto K, Miake S, Hashimoto S. et al. Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei. J Clin Lab Immunol 1985; 17: 91-97