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DOI: 10.1055/a-1178-5158
Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential
Supported by: Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorSupported by: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Supported by: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Supported by: INOVA FIOCRUZ program
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Abstract
Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.
Publication History
Received: 13 September 2019
Accepted after revision: 13 May 2020
Article published online:
14 July 2020
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References
- 1 Griza FT. Análise do Perfil fitoquímico e Avaliação de Efeitos biológicos de Solidago chilensis Meyen [Dissertation]. Canoas: Universidade Luterana do Brasil; 2007
- 2 Heiden G, Iganci JRV, Macias L. Baccharis sect. Caulopterae (Asteraceae, Astereae) no Rio Grande do Sul, Brasil. Rodriguésia 2009; 60: 943-983
- 3 Funk VA, Susanna A, Stuessy TF, Bayer RJ. Systematics, Evolution, and Biogeography of Compositae. Vienna, Austria: International Association for Plant Taxonomy; 2009: 3-34
- 4 Roque N, Bautista H. Asteraceae: Caracterização e Morfologia floral. Salvador, BA: Editora da Universidade Federal da Bahia; 2008: 11-13
- 5 Nikolić M, Stevović S. Family Asteraceae as sustainable planning tool in phytoremediation and its relevance in urban areas. Urban For Urban Gree 2015; 14: 782-789
- 6 Del Vitto LA, Petenatti EM. Asteráceas de importancia económica y ambiental segunda parte: otras plantas útiles y nocivas. Multequina 2015; 24: 47-74
- 7 Simões CMO, Schenkel EP, Gosmann G, de Mello JCP, Mentz LA, Petrovick PR. Farmacognosia: da Planta ao Medicamento, 6th edition. Porto Alegre: Editora da UFRGS; Florianópolis: Editora da UFSC; 2007: 48-51 529–530
- 8 Brasil. Agência Nacional de Vigilância Sanitária. Memento Fitoterápico da Farmacopeia Brasileira. Brasília: Agência Nacional de Vigilância Sanitária; 2016: 1-115
- 9 Brasil. Agência Nacional de Vigilância Sanitária. Formulário de Fitoterápicos da Farmacopeia Brasileira. Brasília: Agência Nacional de Vigilância Sanitária; 2011: 1-126
- 10 Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária (Anvisa). IN 04 de 18 de junho de 2014. Determina a publicação do Guia de orientação para registro de Medicamento Fitoterápico e registro e notificação de Produto Tradicional Fitoterápico. Brasília: Ministério da Saúde. Agência Nacional de Vigilância Sanitária; 2014: 1-123
- 11 Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária (Anvisa). IN 02 de 13 de maio de 2014. Publica a “Lista de medicamentos fitoterápicos de registro simplificado” e a “Lista de produtos tradicionais fitoterápicos de registro simplificado”. Brasília: Ministério da Saúde. Agência Nacional de Vigilância Sanitária; 2014: 1-32
- 12 Ministério da Saúde. Relação Nacional de Plantas Medicinais de Interesse ao Sistema Único de Saúde. Brasília: Ministério da Saúde; 2009: 1-2
- 13 Valverde SS, Oliveira TB, de Souza SP. Solidago chilensis Meyen (Asteraceae). Rev Fitos 2012; 7: 131-136
- 14 Dutra RC, Campos MM, Santos ARS, Calixto JB. Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives. Pharmacol Res 2016; 112: 4-29
- 15 Carvalho ACB, Lana TN, Perfeito JPS, Silveira D. The Brazilian market of herbal medicinal products and the impacts of the new legislation on traditional medicines. J Ethnopharmacol 2018; 212: 29-35
- 16 Guilhermino JF, Siani AC, Quental C, Bomtempo JV. Desafios e complexidade para inovação a partir da biodiversidade brasileira. Rev Pesq Inov Farm 2012; 04: 18-30
- 17 Araújo RFM, Rolim-Neto PJ, Soares-Sobrinho JL, Amaral FMM, Nunes LCC. Phytomedicines: legislation and market in Brazil. Rev Bras Farm 2013; 94: 331-341
- 18 Chagas-Paula DA, Oliveira TB, Faleiro DPV, Oliveira RB, Da Costa FB. Outstanding anti-inflammatory potential of selected Asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase. Planta Med 2015; 81: 1296-1307
- 19 Tadić V, Arsić I, Zvezdanović J, Zugić A, Cvetković D, Pavkov S. The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflammatory potential in topical application. J Ethnopharmacol 2017; 199: 138-148
- 20 Gutierrez MN. Efecto antiinflamatorio y toxicidad aguda del extracto etanólico de Acmella oleracea (L.) R.K. Jansen (Botoncillo) en ratones albinos [thesis]. Cusco-Perú: Universidad Nacional de San Antonio Abad Del Cusco; 2011
- 21 Zapata-Estrella HE, Sánches-Pardenilla ADM, Garcia-Sosa K, Escalante-Erosa F, de Campos-Buzzi F, Meira-Quintão NL, Cechinel-Filho V, Peña-Rodriguez LM. Bioactive metabolites from Cnidoscolus souzae and Acmella pilosa . Nat Prod Commun 2014; 9: 1319-1321
- 22 Romero-Cerecero O, Zamilpa A, González-Cortazar M, Alonso-Cortés D, Jiménez-Ferrer E, Nicasio-Torres P, Aguilar-Santamaría L, Tortoriello J. Pharmacological and chemical study to identify wound-healing active compounds in Ageratina pichinchensis . Planta Med 2013; 79: 622-627
- 23 Avelar-Freitas BA, Almeida VG, Santos MG, Santos JAT, Barroso PR, Grael CFF, Gregório LE, Rocha-Vieira E, Brito-Melo GEA. Essential oil from Ageratum fastigiatum reduces expression of the pro-inflammatory cytokine tumor necrosis factor-alpha in peripheral blood leukocytes subjected to in vitro stimulation with phorbol myristate acetate. Rev Bras Farmacogn 2015; 25: 129-133
- 24 Zahara K, Tabassum S, Sabir S, Arshad M, Qureshi R, Amjad MS, Chaudhari SK. A review of therapeutic potential of Saussurea lappa – an endangered plant from Himalaya. Asian Pac J Trop Med 2014; 7: S60-S69
- 25 De Almeida ABA, Sánchez-Hidalgo M, Martín AR, Luiz-Ferreira A, Trigo JR, Vilegas W, dos Santos LC, Souza-Brito ARM, de la Lastra CA. Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. J Ethnopharmacol 2013; 146: 300-310
- 26 Erdemoglu N, Turan NN, Akkol EK, Sener B, Abacioglu N. Estimation of anti-inflammatory, antinociceptive and antioxidant activities on Arctium minus (Hill) Bernh. ssp minus . J Ethnopharmacol 2009; 121: 318-323
- 27 Gaspar A, Craciunescu O, Trif M, Moisei M, Moldovan L. Antioxidant and anti-inflammatory properties of active compounds from Arnica montana L. Rom. Biotechnol Lett 2014; 19: 9353-9365
- 28 Jäger C, Hrenn A, Zwingmann J, Suter A, Merfort I. Phytomedicines prepared from Arnica flowers inhibit the transcription factors AP-1 and NF-κB and modulate the activity of MMP1 and MMP13 in human and bovine chondrocytes. Planta Med 2009; 75: 1319-1325
- 29 Jaleel GARA, Abdallah HMI, Gomaa NELS. Pharmacological effects of ethanol extract of egyptian Artemisia herba-alba in rats and mice. Asian Pac J Trop Biomed 2016; 6: 44-49
- 30 Abu-Darwish MS, Cabral C, Gonçalves MJ, Cavaleiro C, Cruz MT, Zulfiqar A, Khan IA, Efferth T, Salgueiro L. Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan. J Ethnopharmacol 2016; 191: 161-168
- 31 Honmore V, Kandhare A, Zanwar AA, Rojatkar S, Bodhankar S, Natu A. Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers. Pharm Biol 2015; 53: 571-581
- 32 Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med 2014; 7: 421-428
- 33 Alberto MR, Zampini IC, Isla MI. Inhibition of cyclooxygenase activity by standardized hydroalcoholic extracts of four Asteraceae species from the Argentine Puna. Braz J Med Biol Res 2009; 42: 787-790
- 34 Zalewski CA, Passero LFD, Melo ASRB, Corbett CEP, Laurenti MD, Toyama MH, Toyama DO, Romoff P, Fávero OA, Lago JHG. Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella . Pharm Biol 2011; 49: 602-607
- 35 Nogueira NPA, Reis PA, Laranja GAT, Pinto AC, Aiub CAF, Felzenszwalb I, Paes MC, Bastos FF, Bastos VLFC, Sabino KCC, Coelho MGP. In vitro and in vivo toxicological evaluation of extract and fractions from Baccharis trimera with anti-inflammatory activity. J Ethnopharmacol 2011; 138: 513-522
- 36 Shikov AN, Pozharitskaya ON, Makarov VG, Wagner H, Verpoorte R, Heinrich M. Medicinal plants of the russian pharmacopoeia: their history and applications. J Ethnopharmacol 2014; 154: 481-536
- 37 De Ávila PHM, de Ávila RI, dos Santos Filho EX, Bastos CCC, Batista AC, Mendonça EF, Serpa RC, Marreto RN, da Cruz AF, Lima EM, Valadares MC. Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice. Toxicol Rep 2015; 2: 563-573
- 38 Dos Santos Filho EX, da Silva ACG, de Ávila RI, Batista AC, Marreto RN, Lima EM, de Oliveira CMA, Mendonça EF, Valadares MC. Chemopreventive effects of FITOPROT against 5-fluorouracil-induced toxicity in HaCaT cells. Life Sci 2018; 193: 300-308
- 39 Muley BP, Khadabadi SS, Banarase NB. Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): a review. Trop J Pharm Res 2009; 8: 455-465
- 40 Tu Y, Xue Y, Guo D, Sun L, Guo M. Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications. Rev Bras Farmacogn 2015; 25: 553-566
- 41 Koca U, Toker G, Akkol EK. Assessment of the extracts of Centaurea tchihatcheffii Fischer for anti-inflammatory and analgesic activities in animal models. Trop J Pharm Res 2009; 8: 193-200
- 42 Saliba NA, Dakdouki S, Homeidan FR, Kogan J, Bouhadir K, Talhouk S, Talhouk R. Bio-guided identification of an anti-inflammatory guaianolide from Centaurea ainetensis . Pharm Biol 2009; 47: 701-707
- 43 Bahamonde SMA, Flores ML, Córdoba OL. Antinociceptive and anti-inflammatory activities of an aqueous extract of Chiliotrichum diffusum . Rev Bras Farmacogn 2013; 23: 699-705
- 44 Hanh TTH, Hang DTT, Minh CV, Dat NT. Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata . Asian Pac J Trop Med 2011; 4: 760-763
- 45 Tran TVA, Malainer C, Schwaiger S, Hung T, Atanasov AG, Heiss EH, Dirsch VM, Stuppner H. Screening of vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum . J Ethnopharmacol 2015; 159: 36-42
- 46 Da Silva MG, Oliveira FS, Diniz MFFM, Takemura OS. Atividade antiinflamatória do extrato etanólico de Conocliniopsis prasiifolia R. M. King & H. Robinson na resposta celular de neutrófilos. Rev Bras Farmacogn 2008; 18: 569-572
- 47 Lee CL, Yen MH, Hwang TL, Yang JC, Peng CY, Chen CJ, Chang WY, Wu YC. Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia . Phytochem Lett 2015; 12: 237-242
- 48 Nyalambisa M, Oyemitan IA, Matewu R, Oyedeji OO, Oluwafemi OS, Songca SP, Nkeh-Chungag BN, Oyedeji AO. Volatile constituents and biological activities of the leaf and root of Echinacea species from South Africa. Saudi Pharm J 2017; 25: 381-386
- 49 Bouzabata A, Mahomoodally F, Tuberoso C. Ethnopharmacognosy of Echinops spinosus L. in North Africa: a mini review. J Complement Med Res 2018; 8: 40-52
- 50 Morel LJF, de Azevedo BC, Carmona F, Contini SHT, Teles AM, Ramalho FS, Bertoni BW, França SC, Borges MC, Pereira AMS. A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. J Ethnopharmacol 2017; 198: 226-234
- 51 Arunachalam G, Subramanian N, Pazhani GP, Ravichandran V. Anti-inflammatory activity of methanolic extract of Eclipta prostrata L. (Astearaceae). Afr J Pharm Pharmaco 2009; 3: 97-100
- 52 Araújo AAS, Bonjardim LR, Mota ÉM, Albuquerque-Júnior RLC, Estevam CS, Cordeiro L, Seixas SRS, Batista JS, Quintans-Júnior LJ. Antinociceptive activity and toxicological study of aqueous extract of Egletes viscosa Less (Asteraceae). Braz J Pharm Sci 2008; 44: 707-715
- 53 Nworu CS, Akah PA, Okoye FBC, Esimone CO. Inhibition of pro-inflammatory cytokines and inducible nitric oxide by extract of Emilia sonchifolia L. aerial parts. Immunopharm Immunot 2012; 34: 925-931
- 54 Silvério MS, Sousa OV, Del-Vechio-Vieira G, Miranda MA, Matheus FC, Kaplan MAC. Propriedades farmacológicas do extrato etanólico de Eremanthus erythropappus (DC.) McLeisch (Asteraceae). Rev Bras Farmacogn 2008; 18: 430-435
- 55 Jo MJ, Lee JR, Cho IJ, Kim YW, Kim SC. Roots of Erigeron annuus attenuate acute inflammation as mediated with the inhibition of NF-κB-associated nitric oxide and prostaglandin E2 production. Evid-Based Compl Alt 2013; 2013: 1-10
- 56 Maas M, Deters AM, Hensel A. Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines. J Ethnopharmacol 2011; 137: 371-381
- 57 Ashafa AOT, Yakubu MT, Grierson DS, Afolayan AJ. Evaluation of aqueous extract of Felicia muricata leaves for anti-inflammatory, antinociceptive, and antipyretic activities. Pharm Biol 2010; 48: 994-1001
- 58 Ali S, Zameer S, Yagoob M. Ethnobotanical, phytochemical and pharmacological properties of Galinsoga parviflora (Asteraceae): a review. Trop J Pharm Res 2017; 16: 3023-3033
- 59 Piornedo RR, de Souza P, Stefanello MÉA, Strapasson RLB, Zampronio AR, Kassuya CAL. Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. J Ethnopharmacol 2011; 133: 1077-1084
- 60 Lucarini R, Tozatti MG, Silva MLA, Gimenez VMM, Pauletti PM, Groppo M, Turatti ICC, Cunha WR, Martins CHG. Antibacterial and anti-inflammatory activities of an extract, fractions, and compounds isolated from Gochnatia pulchra aerial parts. Braz J Med Biol Res 2015; 48: 822-830
- 61 Tan HL, Chan KG, Pusparajah P, Lee LH, Goh BH. Gynura procumbens: an overview of the biological activities. Front Pharmacol 2016; 7: 1-14
- 62 Süntar I, Akkol EK, Keles H, Yesilada E, Sarker SD. Exploration of the wound healing potential of Helichrysum graveolens (Bieb.) Sweet: isolation of apigenin as an active component. J Ethnopharmacol 2013; 149: 103-110
- 63 Rigano D, Formisano C, Pagano E, Senatore F, Piacente S, Masullo M, Capasso R, Isso AA, Borrelli F. A new acetophenone derivative from flowers of Helichrysum italicum (Roth) Don ssp · italicum . Fitoterapia 2014; 99: 198-203
- 64 Kothavade PS, Nagmoti DM, Bulani VD, Juvekar AR. Arzanol, a potent mPGES-1 inhibitor: novel anti-inflammatory agent. The Scientific World Jo 2013; 1-9
- 65 Escobedo-Martínez C, Guzmán-Gutiérrez SL, Hernández-Méndez MM, Cassani J, Trujillo-Valdivia A, Orozco-Castellanos LM, Enríquez RG. Heliopsis longipes: anti-arthritic activity evaluated in a Freundʼs adjuvant-induced model in rodents. Rev Bras Farmacogn 2017; 27: 214-219
- 66 Hernández I, Lemus Y, Prieto S, Molina-Torres J, Garrido G. Anti-inflammatory effect of an ethanolic root extract of Heliopsis longipes in vitro . B Latinoam Caribe Pl 2009; 8: 160-164
- 67 Gorzalczany S, Rosella MA, Spegazzini ED, Acevedo C, Debenedetti SL. Anti-inflammatory activity of Heterotheca subaxillaris var. latifolia (Buckley) Gandhi & R.D. Thomas, Asteraceae. Rev Bras Farmacogn 2009; 19: 876-879
- 68 Paliwal SK, Sati B, Faujdar S, Sharma S. Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C. B Clarke. J Tradit Complement Med 2017; 7: 532-537
- 69 Liu L, Hua Y, Wang D, Shan L, Zhang Y, Zhu J, Jin H, Li H, Hu Z, Zhang W. A sesquiterpene lactone from a medicinal herb inhibits proinflammatory activity of TNF-α by inhibiting ubiquitin-conjugating enzyme UbcH5. Chem Biol 2014; 21: 1341-1350
- 70 Valero MS, Berzosa C, Langa E, Gómez-Rincón C, López V. Jasonia glutinosa D. C (“Rock tea”): botanical, phytochemical and pharmacological aspects. B Latinoam Caribe Pl 2013; 12: 543-557
- 71 Nader M, Vicente G, da Rosa JS, Lima TC, Barbosa AM, Santos ADC, Barison A, Dalmarco EM, Biavatti MW, Fröde TS. Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy. Inflammopharmacol 2014; 22: 351-365
- 72 Capelari-Oliveira P, Paula CA, Rezende SA, Campos FT, Grabe-Guimarães A, Lombardi JA, Saúde-Guimarães DA. Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian “Arnica”). J Ethnopharmacol 2011; 135: 393-398
- 73 Ugoline BCA, de Souza J, Ferrari FC, Ferraz-Filha ZS, Coelho GB, Saúde-Guimarães DA. The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica). J Ethnopharmacol 2017; 198: 444-450
- 74 Hebeda CB, Bolonheis SM, Nakasato A, Belinati K, Souza PDC, Gouvea DR, Lopes NP, Farsky SHP. Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus. J Ethnopharmacol 2011; 135: 261-269
- 75 De Souza MR, de Paula CA, de Resende MLP, Grabe-Guimarães A, de Souza Filho JD, Saúde-Guimarães DA. Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. J Ethnopharmacol 2012; 142: 845-850
- 76 Ortiz MI, Fernández-Martínez E, Soria-Jasso LE, Lucas-Gómez I, Villagómez-Ibarra R, González-García MP, Castañeda-Hernández G, Salinas-Caballero M. Isolation, identification and molecular docking as cyclooxygenase (COX) inhibitors of the main constituents of Matricaria chamomilla L. extract and its synergistic interaction with diclofenac on nociception and gastric damage in rats. Biomed Pharmacother 2016; 78: 248-256
- 77 Siddiqui SA, Rahman A, Rahman MO, Akbar MA, Ali MA, Al-Hemaid FMA, Elshikh MS, Farah MA. A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi J Biol Sci 2018; DOI: 10.1016/j.sjbs.2018.03.002.
- 78 Siddiqui SA, Rahman A, Rahman MO, Akbar MA, Rouf ASS, Ali MA, Al-Hemaid FMA, Farah MA. Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) Robinson in experimental animal model. Saudi J Biol Sci 2018; DOI: 10.1016/j.sjbs.2018.01.009.
- 79 Mourão VB, Giraldil GM, Neves LMG, de Gaspi FOG, Rodrigues RAF, Alves AA, Esquisatto MAM, Mazzi MV, Mendonça FAS, dos Santos GMT. Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats. Acta Cir Bras 2014; 29: 30-37
- 80 Vanderlinde FA, Rocha FF, Malvar DC, Ferreira RT, Costa EA, Florentino IF, Guilhon GMSP, de Lima TCM. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Rev Bras Farmacogn 2012; 22: 150-156
- 81 Pérez-Amador MC, Ocotero VM, Balcazar RI, Jiménez FG. Phytochemical and pharmacological studies on Mikania micrantha H.B.K. (Asteraceae). Rev Int Bot Exp 2010; 79: 77-80
- 82 Gutiérrez-Rebolledo GA, Pérez-González MZ, Zamilpa A, Jiménez-Arellanes MA. Anti-inflammatory evaluation and acute toxicity of three food supplements tha contain Moussonia deppeana . Asian Pac J Trop Med 2017; 10: 141-147
- 83 Almeida VG, Avelar-Freiras BA, Santos MG, Costa LA, Silva TJ, Pereira WF, Amorim MLL, Grael CFF, Gregório LE, Rocha-Vieira E, Brito-Melo GEA. Inhibitory effect of the Pseudobrickellia brasiliensis (Spreng) R. M. King & H. Rob. aqueous extract on human lymphocyte proliferation and IFN-γ and TNF-α production in vitro . Braz J Med Biol Res 2017; 50: 1-8
- 84 Tundis R, Loizzo MR. A review of the traditional uses, phytochemistry and biological activities of the genus Santolina . Planta Med 2018; 84: 627-637
- 85 Saklani A, Hegde B, Mishra P, Singh R, Mendon M, Chakrabarty D, Kamath DV, Lobo A, Mishra PD, Dagia NM, Padigaru M, Kulkarni-Almeida AA. NF-κB dependent anti-inflammatory activity of chlorojanerin isolated from Saussurea heteromalla . Phytomedicine 2012; 19: 988-997
- 86 Akkol EK, Acikara OB, Süntar I, Citoğlu GS, Keleş H, Ergene B. Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method. J Ethnopharmacol 2011; 137: 1018-1027
- 87 De Souza RR, Bretanha LC, Dalmarco EM, Pizzolatti MG, Fröde TS. Modulatory effect of Senecio brasiliensis (Spreng) Less. in a murine model of inflammation induced by carrageenan into the pleural cavity. J Ethnopharmacol 2015; 168: 373-379
- 88 Oliveira RB, Chagas-Paula DA, Secatto A, Gasparoto TH, Faccioli LH, Campanelli AP, da Costa FB. Topical anti-inflammatory activity of yacon leaf extracts. Rev Bras Farmacogn 2013; 23: 497-505
- 89 Goulart S, Moritz MIG, Lang KL, Liz R, Schenkel EP, Fröde TS. Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. J Ethnopharmacol 2007; 113: 346-353
- 90 Liz R, Vigil SVG, Goulart S, Moritz MIG, Schenkel EP, Fröde TS. The anti-inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch. J Pharm Pharmacol 2008; 60: 515-521
- 91 Tamura EK, Jimenez RS, Waismam K, Gobbo-Neto L, Lopes NP, Malpezzi-Marinho EAL, Marinho EAV, Farsky SHP. Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation. J Ethnopharmacol 2009; 122: 478-485
- 92 Gastaldo BC. Ação de constituintes de Solidago chilensis Meyen (arnica brasileira) nos mecanismos de cicatrização de feridas em ratos [dissertation]. São Paulo: Universidade de São Paulo; 2013
- 93 Assini FL, Fabrício EJ, Lang KL. Efeitos farmacológicos do extrato aquoso de Solidago chilensis Meyen em camundongos. Rev Bras Pl Med Botucatu 2013; 15: 130-134
- 94 da Silva AG, Machado ER, de Almeida LM, Nunes RMM, Giesbrecht PCP, Costa RM, Costa HB, Romão W, Kuster RM. A clinical trial with brazilian arnica (Solidago chilensis Meyen) glycolic extract in the treatment of tendonitis of flexor and extensor tendons of wrist and hand. Phytother Res. 2015; 29: 864-869
- 95 Brito TM, Amendoeira FC, Garcia EB, Fontenelle FM, Doro LH, Chaves AS, Félix NM, Valverde SS, Ferraris FK. Avaliação in vivo e in vitro da atividade anti-inflamatória de diferentes frações de Solidago chilensis. XI Simpósio Brasileiro de Farmacognosia/XVI Simposio Latinoaméricano de Farmacobotanica. Curitiba, PR: Sociedade Brasileira de Farmacognosia; 2017
- 96 Ulrich-Merzenich G, Hartbrod F, Kelber O, Müller J, Koptina A, Zeitler H. Salicylate-based phytopharmaceuticals induce adaptive cytokine and chemokine network responses in human fibroblast cultures. Phytomedicine 2017; 34: 202-211
- 97 Motaal AA, Ezzat SM, Tadros MG, El-Askary HI. In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaurea in rats. Pharm Biol 2016; 54: 2864-2870
- 98 Vilela FC, Bitencourt AD, Cabral LDM, Franqui LS, Soncini R, Giusti-Paiva A. Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats. J Ethnopharmacol 2010; 127: 737-741
- 99 Fucina G, Rocha LW, da Silva GF, Hoepers SM, Ferreira FP, Guaratini T, Cechinel Filho V, Lucinda-Silva RM, Quintão NLM, Bresolin TMB. Topical anti-inflammatory phytomedicine based on Sphagneticola trilobata dried extracts. Pharm Biol 2016; 54: 2465-2474
- 100 De Carli RBG, Siqueira PRA, Kaiser ML, Freitas RA, de Souza MM, Cechinel-Filho V, Lucinda-Silva RM. Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in mice. Lat Am J Pharm 2009; 28: 594-598
- 101 Vaid M, Katiyar SK. Molecular mechanisms of inhibition of photocarcinogenesis by silymarin, a phytochemical from milk thistle (Silybum marianum L. Gaertn). Int J Oncol 2010; 36: 1053-1060
- 102 Samanta R, Pattnaik AK, Pradhan KK, Mehta BK, Pattanayak SP, Banerjee S. Wound healing activity of silibinin in mice. Pharmacogn Res 2016; 8: 298-302
- 103 Karimian P, Kavoosi G, Amirghofran Z. Anti-oxidative and anti-inflammatory effects of Tagetes minuta essential oil in activated macrophages. Asian Pac J Trop Biomed 2014; 4: 219-227
- 104 Shinde NV, Kanase KG, Shilimkar VC, Undale VR, Bhosale AV. Antinociceptive and anti-inflammatory effects of solvent extracts of Tagetes erectus Linn (Asteraceae). Trop J Pharm Res 2009; 8: 325-329
- 105 Albayrak G, Nalbantsoy A, Baykan Ş. In vitro cytotoxic and anti-inflammatory activities of Tanacetum argenteum (Lam.) Willd. subsp. argenteum extract. Turk J Pharm Sci 2017; 14: 231-236
- 106 Gomes BS, Neto BPS, Lopes EM, Cunha FVM, Araújo AR, Wanderley CWS, Wong DVT, Júnior RCPL, Ribeiro RA, Souza DP, Medeiros JVR, Oliveira RCM, Oliveira FA. Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress. Chem Biol Interact 2017; 273: 73-81
- 107 Özbilgin S, Akkol EK, Öz BE, Ilhan M, Saltan G, Acıkara ÖB, Tekin M, Keleş H, Süntar I. In vivo activity assessment of some Tanacetum species used as traditional wound healer along with identification of the phytochemical profile by a new validated HPLC method. Iran J Basic Med Sci 2018; 21: 145-152
- 108 Martinez M, Poirrier P, Chamy R, Prüfer D, Schulze-Gronover C, Jorquera L, Ruiz G. Taraxacum officinale and related species – an ethnopharmacological review and its potential as a commercial medicinal plant. J Ethnopharmacol 2015; 169: 244-262
- 109 Chagas-Paula DA, de Oliveira RB, da Silva VC, Gobbo-Neto L, Gasparoto TH, Campanelli AP, Faccioli LH, da Costa FB. Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. J Ethnopharmacol 2011; 136: 355-362
- 110 Abe AE, de Oliveira CE, Dalboni TM, Chagas-Paula DA, Rocha BA, de Oliveira RB, Gasparoto TH, da Costa FB, Campanelli AP. Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils. Rev Bras Farmacogn 2015; 25: 111-116
- 111 Heidari M, Bahramsoltani R, Abdolghaffari AH, Rahimi R, Esfandyari M, Baeeri M, Hassanzadeh G, Abdollahi M, Farzaei MH. Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds. J Tradit Complement Med 2018; DOI: 10.1016/j.jtcme.2018.02.002.
- 112 Erdoğan TF, Akkol EK, Süntar I, Gönenç TM, Kıvçak B. Fatty acid compositions and anti-inflammatory activities of Tripleurospermum parviflorum (Willd.) Pobed. and Tripleurospermum tenuifolium (Kit.). Rec Nat Prod 2015; 9: 394-403
- 113 Vogl S, Picker P, Mihaly-Bison J, Fakhrudin N, Atanasov AG, Heiss EH, Wawrosch C, Reznicek G, Dirsch VM, Saukel J, Kopp B. Ethnopharmacological in vitro studies on Austriaʼs folk medicine – an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs. J Ethnopharmacol 2013; 149: 750-771
- 114 Da Silva JB, Mendes RF, Tomasco V, Pinto NCC, de Oliveira LG, Rodrigues MN, Aragão DMO, de Aguiar JAK, Alves MS, Castañon MCNM, Ribeiro A, Scio E. New aspects on the hepatoprotective potential associated with the antioxidant, hypocholesterolemic and anti-inflammatory activities of Vernonia condensata Baker. J Ethnopharmacol 2017; 198: 399-406
- 115 Minateli MM, Del-Vechio-Vieira G, Yamamoto CH, Araújo ALS, Rodarte MP, Alves MS, Souza OV. Phytochemical contents and biological properties of Vernonia polyanthes Less. Int J Pharm Sci Res 2017; 8: 1427-1436
- 116 Rauh LK, Horinouchi CDS, Loddi AMV, Pietrovski EF, Neris R, Souza-Fonseca-Guimarães F, Buchi DF, Biavatti MW, Otuki MF, Cabrini DA. Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes. J Ethnopharmacol 2011; 138: 390-397
- 117 Bader A, Giner RM, Martini F, Schinella GR, Ríos JL, Braca A, Prieto JM. Modulation of COX, LOX and NF-κB activities by Xanthium spinosum L. root extract and ziniolide. Fitoterapia 2013; 91: 284-289
- 118 Hossen MJ, Cho JY, Kim D. PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities. J Ethnopharmacol 2016; 190: 251-260
- 119 Applequist WL, Moermann DE. Yarrow (Achillea millefolium L.): a neglected panacea? A review of ethnobotany, bioactivity, and biomedicam research. Econ Bot 2011; 65: 209-225
- 120 Brasil. Agência Nacional de Vigilância Sanitária. Formulário de Fitoterápicos Farmacopeia Brasileira–Primeiro Suplemento. Brasília: Agência Nacional de Vigilância Sanitária; 2018: 1-160
- 121 Bessada SMF, Barreira JCM, Oliveira MBPP. Asteraceae species with most prominent bioactivity and their potential applications: a review. Ind Crop Prod 2015; 76: 604-615
- 122 Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SMY, Leung GPH, Yu PHF, Chan SW. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology 2010; DOI: 10.1007/s10787-010-0062-4.
- 123 Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária (Anvisa). RDC N°26 de 13 de maio de 2014. Dispõe sobre o registro de medicamentos fitoterápicos e o registro e a notificação de produtos tradicionais fitoterápicos. Brasília: Ministério da Saúde. Agência Nacional de Vigilância Sanitária; 2014: 1-34
- 124 Fragoso TP. Análise do uso medicinal do gênero Artemisia no Brasil com base em fatores tradicionais, científicos, políticos e patentários para subsidiar o Programa Nacional de Plantas Medicinais e Fitoterápicos [Monography]. Rio de Janeiro: Farmanguinhos, Fiocruz; 2014
- 125 Borges CC, Matos TF, Moreira J, Rossato AE, Zanette VC, Amaral PA. Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil. Rev Bras Pl Med Botucatu 2013; 15: 34-40
- 126 Ministério da Saúde. Anvisa. Monografia da espécie Bidens pilosa (Picão – preto) Brasília. Brasília: Ministério da Saúde. Agência Nacional de Vigilância Sanitária; 2015: 1-85
- 127 Ferrari FC, Grabe-Guimarães A, Carneiro CM, de Souza MR, Ferreira LC, de Oliveira TT, Saúde-Guimarães DA. Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica. Rev Bras Farmacogn 2012; 22: 1104-1110
- 128 De Liz R. Estudo do efeito antiinflamatório da Solidago chilensis Meyen em modelo de inflamação induzida pela carragenina, em camundongos [Dissertation]. Florianópolis: Universidade Federal de Santa Catarina; 2007
- 129 Vechia CAD, Morais B, Schonell AP, Diel KAP, Faust C, Menin C, Gomes DB, Roman Junior WA. Isolamento químico e validação analítica por cromatografia líquida de alta eficiência de quercitrina em Solidago chilensis Meyen (Asteraceae). Rev Bras Pl Med 2016; 18: 288-296
- 130 Valverde-Soares SS, Azevedo-Silva RC, Tomassini TCB. Utilização de CLAE, como paradigma na obtenção e controle do diterpeno solidagenona a partir de inflorescências de Solidago chilensis Meyen (arnica brasileira). Rev Bras Farm 2009; 90: 196-199
- 131 Russo A, Garbarino J. Solidago chilensis Meyen and Kageneckia oblonga Ruiz & Pav.: a minireview on their antioxidant profile. Phytotherapie 2008; 6: 333-341
- 132 Universidade Federal de Lavras-MG. Departamento de Medicina Veterinária. Métodos de avaliação laboratorial da atividade antinociceptiva e anti-inflamatória de produtos naturais. Boletim Técnico nº. 97. Available at (Accessed September 15, 2018): http://www.editora.ufla.br/index.php/component/phocadownload/category/10-boletins?download=1009:boletins
- 133 Algressi E, Ben-Lulu O. Treatment of wounds by providing core active ingredients comprising Calendula infused in oil, Achillea millefolium tincture in alcohol, Syzygium aromaticum floral water extract, Helichrysum essential oil and honeybee product e.g. raw honey. EP Patent 3331541-A4, 2018
- 134 Attenot N, Claisse N, Ricochon G. Extract of leaves of lettuce e.g. lettuces of Asteraceae family, used e.g. as antiinflammatory, soothing and/or smoothing agent and in non-therapeutic treatment of skin to prevent photo-aging, comprises polyphenolic compounds. EP Patent 3042662-A1, 2016
- 135 Bernard P, Humbert F, Do Quoc T. Processing herbaceous plant belongs to Asteraceae, by subjecting plant to extraction process, extracting oil from plants, and separating oil and solid cake. FR Patent 3019041-B1, 2016
- 136 Campos FR, Jasinski VCG, Beltrame FL, Minozzo BR. Extract used for treating ulcer of human and veterinary, comprises cladodes, leaves and flowers of Baccharis glaziovii Baker belonging to Asteraceae family, in juice, tincture, infusion, extraction, mass, dust and fraction forms. BR Patent 102015024304-A2, 2015
- 137 Canigueral FS, Risco RE, Sciotto S, Vila CR, Folcara S, Casanovas R, Rodriguez E. Preparing aqueous extracts of plants useful in e.g. cosmetic or pharmaceutical topical composition for treating inflammatory skin condition or disease, by suspending plant in water, macerating suspension, and separating liquid. EP Patent 3052112-A1, 2016
- 138 Ennamany R. Composition used as e.g. topical cosmetic composition and anti-aging composition, comprises plant cells dedifferentiated and elicited in in vitro culture, or ground material of the dedifferentiated plant cells containing phytoalexin. EP Patent 3250295-A2, 2017
- 139 Engstad RE, Johansen FE, Sandvik A, Johansen F. Use of glucan derived from yeast having beta-(1,3)-backbone with beta-(1,3)-side chains linked to it, or meal/protein derived from Asteraceae, for treatment/prevention of e.g. ulcerative colitis constipation, Crohnʼs disease and diarrhea. AU Patent 2008322737-A1, 2009
- 140 Galindo GJH. Pharmaceutical composition used as cosmetic for treating e.g. seborrhea and acne vulgaris, comprises Matricaria recutita extract, where salicylic acid, resorcinol, lactic acid, ascorbic acid, Comperlan and Texapon are present in extract. MX Patent 2009001657-A1, 2009
- 141 Hui KG, Hyeok LJ, Jeong CE, Suk PH. Composition useful for preventing inflammation, obesity and cancer, comprises extract of Asteraceae plant including e.g. Aster spathulifolius, Chrysanthemum boreale, Chrysanthemum morifolium, Chrysanthemum indicum, and Coreopsis drummondii . KR Patent 2014088504-A, 2014
- 142 Jean D, Cariel L. Treating post-traumatic edema, especially for rapid elimination of post-operative hematomas, by topical administration of sesquiterpene lactone, e.g. helenalin or cnicin. FR Patent 2807319-A1, 2001
- 143 Jia Q, Burnett B, Qi J, Bruce B. Use of a composition (containing free-B-ring flavonoid and flavan) for the treatment or prevention of cyclooxygenase and lipoxygenase mediated diseases and conditions of the skin. EP Patent 1631304-A4, 2007
- 144 Kaneko A. Immunoglobulin E and interleukin-4 production suppression composition used in food-drinks for reducing allergy, respiratory constriction, edema and nasal discharge, comprises organic-solvent extract of Silybum marianum of Asteraceae. JP Patent 2012158528-A, 2012
- 145 Kato A, Ishikawa F. Ceramidase activation inhibitor used for treating atopic and asteatosis dermatitis, comprises extract of malvaceae, rubiaceae, gramineae, parmeliaceae, styracaceae, asteraceae, lauraceae, verbenaceae and papaveraceae plant. JP Patent 2017124984-A, 2017
- 146 Kim IS, Paek JS, Jin YW, Lee EK, Hong SM. New stem cell derived from cambium layer of Asteraceae plant e. g. Chrysanthemum morifolium, useful in pharmaceutical composition or functional food for preventing and/or treating inflammation. EP Patent 2436757-A2, 2012
- 147 Kim GH, Je HL, Eun JC, Hee SP. Composition used for providing antioxidant effect and preventing and treating inflammation, cancer and obesity, comprises extract of Asteraceae plant e.g. Aster spathulifolius and Chrysanthemum morifolium . KR Patent 1537847-B1, 2015
- 148 Koganov M. Cosmetic ingredient used in cosmetic industry comprises membrane fraction derived from cell juice extracted from fresh plant biomass, and stabilizing agent. AU Patent 2003239875-A1, 2003
- 149 Koganov M, Dueva-Koganov O. Bioactive botanical cosmetic composition useful for, e.g. inhibiting antiinflammatory activity in skin tissue of mammal, comprises membrane fraction derived from cell juice extracted from fresh plant biomass, and stabilizing agent. US Patent 7442391-B2, 2008
- 150 Koganov M. Bioactive botanical cosmetic composition for preparing cosmetic formulation for inhibiting antiinflammatory activity in skin tissue of mammal, comprises membrane fraction derived from cell juice from fresh plant biomass, and stabilizer. US Patent 8101212-B2, 2012
- 151 Koganov M. Cosmetic composition useful for e.g. inhibition of proliferation of cells comprises a membrane fraction derived from cell juice extracted from fresh plant biomass and having a cell growth inhibition activity; and a stabilizing agent. US Patent 8663712-B2, 2014
- 152 Koganov M. Bioactive botanical cosmetic composition, useful e.g. for normalization of cell disorders in skin tissue of a mammal, comprises a membrane fraction derived from cell juice extracted from a fresh plant biomass and a stabilizing agent. US Patent 8734861-B2, 2012
- 153 Koganov M. Bioactive botanical cosmetic composition, useful for inhibiting antiinflammatory activity in skin tissue of mammal, comprises membrane fraction derived from cell juice extracted from fresh plant biomass and stabilizing agent. US Patent 2014295004-A1, 2014
- 154 Koganov M, Zhang L, Duev A. Composition, preferably personal care product with reduced inflammation properties towards biological skin useful for reducing inflammation of biological tissue, comprises surfactant and plant fraction e.g. cytoplasm fraction. AU Patent 2014231030-B2, 2018
- 155 Kondo C, Yokoyama K. Skin external preparation useful for e.g. whitening skin and preventing pigmentation caused by UV exposure or abnormal pigmentation, comprises aromatic compound and its pharmaceutically acceptable salt, and anti-inflammatory components. JP Patent 6246993-B2, 2017
- 156 Mackova A. Physiological active medicinal herbs mixture useful for providing anti-inflammatory effect and analgesic effect, comprises medicinal herb extracts and/or oils e.g. Hamamelis species of Hamamelidaceae and Glycyrrhiza species of Fabaceae. DE Patent 102017002005-A1, 2018
- 157 Obukowicz MG, Hummert SL. Composition useful in the treatment of e.g. cyclooxygenase mediated inflammation, comprises an organic extract of an edible plant. AU Patent 2002230985-A8, 2005
- 158 Obukowicz MG, Hummert SL. Use of an organic extract of an edible plant for inhibition of cyclooxygenase-2 in the treatment of e.g. inflammation, arthritis, pain, fever, cancer, or a central nervous system disorder. US Patent 2004185122-A1, 2004
- 159 Okubo T. Agent useful for improving skin function, preventing and/or treating inflammation e.g. dermatitis, and scleroderma, and masking wrinkles, comprises extract of plant belonging to family Asteraceae (Compositae), preferably Matricaria . JP Patent 2014129253-A, 2014
- 160 Omer HA. Method to counteract the weight loss and nutritional deficiency of cancer patients and to treat e.g. rheumatic diseases, lupus, colitis, immunoglobulin A-nephropathy and human cancers with herbal preparation having Artemisia . US Patent 20080311230-A1, 2008
- 161 Ramirez SC. Product used as analgesic, antiinflammatory and antipyretic, comprises salicylate (acetyl salicylic acid or its analog) with Asteraceae plant crude extract in liquid or solid form to produce synergistic activity. MX Patent 2013004050-A, 2013
- 162 Sato T, Tsubata A, Kitamura S, Takagaki K. Agent useful e.g. as intestinal regulator, antiallergic agent, immunostimulant, and lactic acid bacteria intestinal adhesion improver, comprises extract of flower chosen from family Lythraceae, Asteraceae, Fabaceae, Rosaceae or Iridaceae. JP Patent 2018062468-A, 2018
- 163 Shimanuki T. Skin external preparation useful as cosmetics and quasi-drug for preventing pigmentation, skin senility, wrinkles and acne, comprises formamide containing compound. JP Patent 6255154-B2, 2017
- 164 Shen H. Protective liquid useful for e.g. treating eczema of infants, contains water, hyaluronic acid, dipotassium glycyrrhizinate, disodium EDTA, allantoin, trehalose, raffinose, methyl propylene glycol, p-hydroxyacetophenone and coceth-7. CN Patent 107753666-A, 2017
- 165 Skabelund RE. Composition for treating urogenital/urological disorder, e.g. interstitial cystitis or benign prostatic hypertrophy, comprises at least part of plant in the family Asteraceae. US Patent 6749871-B2, 2004
- 166 Wilmanowicz R. Immunologically active phytomixture used in composition for preventing and treating e.g. eczema, comprises plant extract chosen from Bidens from Asteraceae, Stachytarpheta from Verbenaceae and/or Bursera from Burseraceae. CN Patent 107889461-A, 2018
- 167 Bozinis MCV, Lima EM, Batista AC, Marreto RN, de Mendonça EF. Soluble, stable, anti-inflammatory, proliferative, protective and mucoadhesive pharmaceutical compositions; use thereof for treating mucositis conditions and method for producing same; base pharmaceutical composition for preparing the pharmaceutical compositions and method for producing same. WO Patent 2016065442-A1, 2016
- 168 Lima EM, Bozinis MCV, Batista AC, Marreto RN, de Mendonça EF. Composições farmacêuticas antiinflamatórias, proliferativas, protetoras e mucoadesivas, solúveis e estáveis; seu uso no tratamento dos quadros de mucosite e processo de obtenção. BR Patent 10 2013 003316 2- A2, 2015
- 169 Agência Nacional de Vigilância Sanitária. Consultas. Available at (Accessed October 30, 2018): https://consultas.anvisa.gov.br/%23/medicamentos/
- 170 Secretaria Municipal de Saúde e Defesa Civil. Prefeitura da Cidade do Rio de Janeiro. Programa de Plantas Medicinais e Fitoterapia. Manual Terapêutico de Fitoterápicos. Rio de Janeiro: Secretaria Municipal de Saúde e Defesa Civil; 2010: 1-15
- 171 Brasil. Ministério da Saúde. Política Nacional de Práticas Integrativas e Complementares do SUS: Atitude de ampliação de acesso. Brasília: Ministério da Saúde; 2006: 1-92
- 172 Brasil. Ministério da Saúde. Programa Nacional de Plantas Medicinais e Fitoterápicos. Brasília: Ministério da Saúde; 2009: 1-140