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DOI: 10.1055/a-1148-2546
Moderators of the Association Between Serum Parathyroid Hormone and Metabolic Syndrome in Participants with Elevated Parathyroid Hormone: NHANES 2003–2006
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Abstract
This cross-sectional study extracted data of 392 NHANES participants with elevated serum parathyroid hormone (PTH) concentrations from 2 cycles of the US National Health and Nutrition Examination Survey (NHANES) 2003–2006 and evaluated the association between serum (PTH) concentration and metabolic syndrome (MetS) to identify dietary and lifestyle factors that may modify that association. The primary outcome was MetS severity scores. Results of univariate linear regression analyses revealed that serum PTH concentrations correlated positively and significantly with MetS severity scores (β=0.399, p=0.030). After adjusting for gender, age, race, and alcohol consumption, results of multivariate analysis revealed that increased serum PTH concentration correlated significantly with higher MetS severity scores (β=0.413, p=0.045) in participants with moderate physical activity over the past 30 days. Serum PTH concentration also correlated significantly with higher MetS severity scores in participants with serum 25-hydroxyvitamin D deficiency (β=0.456 and p=0.014), those without vitamin D supplementation (β=0.524, p=0.028) and with higher protein intake (β=0.586 and p=0.030). In conclusion, increased serum PTH concentration is associated with higher MetS severity scores in participants with elevated serum PTH at baseline. The association between PTH concentration and MetS severity is moderated by participants’ physical activity levels, status of serum vitamin D, vitamin D supplementation, and daily protein intake.
Key words
parathyroid hormone - hyperparathyroidism - dietary and lifestyle factors - metabolic syndrome - National Health and Nutritional Examination SurveyPublikationsverlauf
Eingereicht: 05. August 2019
Angenommen: 18. März 2020
Artikel online veröffentlicht:
23. April 2020
© Georg Thieme Verlag KG
Stuttgart · New York
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References
- 1 Fu S, Yao Y, Luan F. et al. Prevalence of metabolic syndrome risk factors and their relationships with renal function in Chinese centenarians. Sci Rep 2018; 8: 9863
- 2 Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: A meta-analysis. Am J Med 2006; 119: 812-819
- 3 Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep 2018; 20: 12-16
- 4 Reis JP, von Muhlen D, Kritz-Silverstein D. et al. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care 2007; 30: 1549-1555
- 5 Reis JP, von Muhlen D, Miller ER. Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol 2008; 159: 41-48
- 6 Silverberg SJ, Walker MD, Bilezikian JP. Asymptomatic primary hyperparathyroidism. J Clin Densitom 2013; 16: 14-21
- 7 Kayaniyil S, Vieth R, Harris SB. et al. Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocrinol Metab 2011; 96: 168-175
- 8 Paik JM, Farwell WR, Taylor EN. Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey. Osteoporos Int 2012; 23: 1727-1736
- 9 Aloia JF, Feuerman M, Yeh JK. Reference range for serum parathyroid hormone. Endocr Pract 2006; 12: 137-144
- 10 Vilarrasa N, Vendrell J, Maravall J. et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?. Endocrine 2010; 38: 235-242
- 11 Raposo L, Martins S, Ferreira D. et al. Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study. BMC Endocr Disord 2017; 17: 71
- 12 Kim J. Association between serum vitamin D, parathyroid hormone and metabolic syndrome in middle-aged and older Korean adults. Eur J Clin Nutr 2015; 69: 425-430
- 13 Sotunde OF, Kruger HS, Wright HH. et al. Association of 25-hydroxyvitamin D and parathyroid hormone with the metabolic syndrome in black South African women. Appl Physiol Nutr Metab 2017; 42: 413-419
- 14 Yin X, Sun Q, Zhang X. et al. Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population. Nutr J 2012; 11: 68
- 15 Ford ES, Zhao G, Li C, Pearson WS. Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States. J Diabetes 2009; 1: 296-303
- 16 (CDC) CfDCaP. NHANES 2005–2006. Available at http://wwwcdcgov/nchs/about/major/nhanes/nhanes2005-2006/nhanes05_06htm
- 17 DeBoer MD, Gurka MJ. Clinical utility of metabolic syndrome severity scores: Considerations for practitioners. Diabetes Metab Syndr Obes 2017; 10: 65-72
- 18 Munns CF. Global Consensus Recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab 2016; 101: 394-415
- 19 Tsai J, Ford ES, Li C.. et al. Past and current alcohol consumption patterns and elevations in serum hepatic enzymes among US adults. Addict Behav 2012; 37: 78-84
- 20 Scholl TO, Chen X, Stein TP. Vitamin D, secondary hyperparathyroidism, and preeclampsia. Am J Clin Nutr 2013; 98: 787-793
- 21 Zalesin KC, Miller WM, Nori Janosz KE. et al. Controversies in vitamin D: Deficiency and supplementation after Roux-en-Y-gastric bypass surgery. Therapy 2007; 4: 561-574
- 22 Saab G, Whaley-Connell A, Bombeck A. et al. The Association between parathyroid hormone levels and the cardiorenal metabolic syndrome in non-diabetic chronic kidney disease. Cardiorenal Med 2011; 1: 123-130
- 23 George JA, Norris SA, van Deventer HE. et al. The association of 25 hydroxyvitamin D and parathyroid hormone with metabolic syndrome in 2 ethnic groups in South Africa. PLoS One 2013; 8: e61282
- 24 Bouassida A, Latiri I, Bouassida S. et al. Parathyroid hormone and physical exercise: A brief review. J Sports Sci Med 2006; 5: 367-374
- 25 Lorenzo V, Martin M, Rufino M. et al. Protein intake, control of serum phosphorus, and relatively low levels of parathyroid hormone in elderly hemodialysis patients. Am J Kidney Dis 2001; 37: 1260-1266
- 26 Richter M, Baerlocher K, Bauer JM. et al. German Nutrition Society (DGE). Revised reference values for the intake of protein. Protein.Ann Nutr Metab 2019; 74: 242-250