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Horm Metab Res 2020; 52(02): 109-116
DOI: 10.1055/a-1082-1080
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Decreased Circulating MANF in Women with PCOS is Elevated by Metformin Therapy and is Inversely Correlated with Insulin Resistance and Hyperandrogenism

Jie Wei    *
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Cong Wang   *
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Gangyi Yang
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Yanjun Jia
2   Laboratory of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Yang Li
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Wenzhen Deng
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Min Long
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Chengpan Wang
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Dongfang Liu
1   Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
3   Chongqing Clinical Research Center for Geriatrics and Gerontology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
› Author Affiliations Funding Information Medical Scientific Research Project of Chongqing Health Planning Committee; Grant Nos: 2016MSXM030 and 2016ZDXM011. National Natural Science Foundation of China; Grant Nos: 81370467 and 81501199. Natural Science Foundation Project of Chongqing cstc; Grant Nos: cstc2017jcyjAX0016 and cstc2017shmsA130069.
Further Information

Publication History

received 22 July 2019

Publication Date:
13 February 2020 (online)

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Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel neurotrophic factor. Although recent studies have suggested that MANF appeared to be associated with insulin resistance, the results have been inconsistent. The aim of our study was to determine the serum MANF levels in women with PCOS and controls, to investigate their relationship to insulin resistance, and to evaluate circulating MANF changes with metformin intervention in PCOS women. We conducted a series of cross-sectional and interventional studies in 90 newly diagnosed patients with PCOS and 60 age- and gender-matched controls. Oral glucose tolerance test and euglycemic-hyperinsulinemic clamps were performed to assess the glucose tolerance and insulin sensitivity. Forty-three women with PCOS were randomly assigned to six months of oral metformin therapy. Serum MANF levels were significantly lower in women with PCOS than in controls. Serum MANF levels were positively correlated with M-value and negatively correlated with body mass index (BMI), body fat percentage (FAT), homeostatic model assessment of insulin resistance (HOMA-IR), and free androgen index (FAI). Multivariate stepwise regression demonstrated that serum MANF levels were independently associated with M-value and FAI. After six months of metformin treatment, there was a significant increase in serum MANF levels in PCOS women. Serum MANF levels are decreased in women with PCOS, and are reversely related to insulin resistance and hyperandrogenism. Metformin treatment elevates serum MANF levels and alleviates insulin resistance and hyperandrogenism in PCOS women.

Key words

mesencephalic astrocyte-derived neurotrophic factor - polycystic ovary syndrome - insulin resistance - hyperandrogenism - metformin

* Jie Wei and Cong Wang should be considered as joint first authors.


Supplementary Material

 

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