Pneumologie 2020; 74(03): 137-148
DOI: 10.1055/a-1065-6385
Serie: Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Differenzialtherapie nicht-invasive Beatmung – nasale High-Flow-Therapie

Differential Therapy NIV – NHF
J. Bräunlich
1   Medizinische Klinik, Klinikum Emden gGmbH, Emden
,
H. Wirtz
2   Abt. Pneumologie, Universitätsklinikum Leipzig AöR, Leipzig
› Institutsangaben

Verantwortlicher Herausgeber dieser Rubrik: S. Kluge
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
09. Januar 2020 (online)

Zusammenfassung

Der nasale High-Flow führt zu einer stabilen Sauerstoffzufuhr bei der akuten hypoxämischen respiratorischen Insuffizienz, reduziert die Atmungsarbeit und vermindert die Hyperkapnie. Damit geht der NHF über ein reines Oxygenierungssystem hinaus und zeigt Charakteristika einer Atmungsunterstützung. Verschiedene Untersuchungen unterstützen diese These. Dieser Artikel soll daher diskutieren, ob der NHF in ähnlichen Situationen oder Erkrankungen wie die NIV eingesetzt werden kann.

Abstract

Nasal high-flow provides a stable oxygenation in acute hypoxemic respiratory failure, modifies breathing patterns, reduces work of breathing and can decrease hypercapnia. Thereby NHF provides more features than low-flow oxygen and acts as a ventilatory support device. Different studies show benefits of NHF compared to NIV. For these reasons we will discuss the capabilities of NHF and NIV in selected settings.

 
  • Literatur

  • 1 Brochard L, Isabey D, Piquet J. et al. Reversal of acute exacerbations of chronic obstructive lung disease by inspiratory assistance with a face mask. N Engl J Med 1990; 323: 1523-1530
  • 2 Plant PK, Owen JL, Elliott MW. Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: long term survival and predictors of in-hospital outcome. Thorax 2001; 56: 708-712
  • 3 Antonelli M, Conti G, Rocco M. et al. A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure. N Engl J Med 1998; 339: 429-435
  • 4 Kollef MH. Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med 2004; 32: 1396-1405
  • 5 Rochwerg B, Brochard L, Elliott MW. et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J 2017; 50: 1602426
  • 6 Girou E. Association of Noninvasive Ventilation With Nosocomial Infections and Survival in Critically Ill Patients. JAMA 2000; 284: 2361-2367
  • 7 Osadnik CR, Tee VS, Carson-Chahhoud KV. et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2017; 7: CD004104
  • 8 Hartl S, Lopez-Campos JL, Pozo-Rodriguez F. et al. Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit. Eur Respir J 2016; 47: 113-121
  • 9 Roberts CM, Stone RA, Buckingham RJ. et al. Acidosis, non-invasive ventilation and mortality in hospitalised COPD exacerbations. Thorax 2010; 66: 43-48
  • 10 Gray A, Goodacre S, Newby DE. et al. Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 2008; 359: 142-151
  • 11 Köhnlein T, Windisch W, Köhler D. et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med 2014; 2: 698-705
  • 12 Murphy PB, Rehal S, Arbane G. et al. Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial. JAMA 2017; 317 (21) 2177-2186
  • 13 Struik FM, Sprooten RTM, Kerstjens HAM. et al. Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study. Thorax 2014; 69: 826-834
  • 14 Windisch W, Dreher M, Geiseler J. et al. S2k-Leitlinie: Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen Insuffizienz – Revision 2017. Pneumologie 2017; 71: 722-795
  • 15 Leger P, Bedicam JM, Cornette A. et al. Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency. Chest 1994; 105: 100-105
  • 16 Simonds AK, Elliott MW. Outcome of domiciliary nasal intermittent positive pressure ventilation in restrictive and obstructive disorders. Thorax 1995; 50: 604-609
  • 17 Tissot A, Jaffre S, Gagnadoux F. et al. Staffieri F, ed. Home Non-Invasive Ventilation Fails to Improve Quality of Life in the Elderly: Results from a Multicenter Cohort Study. PLoS ONE 2015; 10: e0141156
  • 18 Manley BJ, Manley BJ, Owen LS. et al. High-flow nasal cannulae in very preterm infants after extubation. N Engl J Med 2013; 369: 1425-1433
  • 19 Parke R, McGuinness S, Eccleston M. Nasal high-flow therapy delivers low level positive airway pressure. Br J Anaesth 2009; 103: 886-890
  • 20 Bräunlich J, Köhler M, Wirtz H. Nasal highflow improves ventilation in patients with COPD. COPD 2016; 11: 1077-1085
  • 21 Mauri T, Eronia N, Turrini C. et al. Bedside assessment of the effects of positive end-expiratory pressure on lung inflation and recruitment by the helium dilution technique and electrical impedance tomography. Intensive Care Med 2016; 42: 1576-1587
  • 22 Mauri T, Alban L, Turrini C. et al. Optimum support by high-flow nasal cannula in acute hypoxemic respiratory failure: effects of increasing flow rates. Intensive Care Med 2017; 43: 1453-1463
  • 23 Pisani L, Fasano L, Corcione N. et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax 2017; 72: 373-375
  • 24 Delorme M, Bouchard P-A, Simon M. et al. Effects of High-Flow Nasal Cannula on the Work of Breathing in Patients Recovering From Acute Respiratory Failure. Crit Care Med 2017; 45: 1981-1988
  • 25 Frizzola M, Miller TL, Rodriguez ME. et al. High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol 2011; 46: 67-74
  • 26 Möller W, Feng S, Domanski U. et al. Nasal high flow reduces dead space. J Appl Physiol 2017; 122: 191-197
  • 27 Bräunlich J, Mauersberger F, Wirtz H. Effectiveness of nasal highflow in hypercapnic COPD patients is flow and leakage dependent. BMC Pulm Med 2018; 18: 14
  • 28 Biselli P, Fricke K, Grote L. et al. Reductions in dead space ventilation with nasal high flow depend on physiological dead space volume: metabolic hood measurements during sleep in patients with COPD and controls. Eur Respir J 2018; 51 DOI: 10.1183/13993003.02251-2017.
  • 29 Katz JA, Marks JD. Inspiratory work with and without continuous positive airway pressure in patients with acute respiratory failure. Anesthesiology 1985; 63: 598-607
  • 30 Chikata Y, Onodera M, Oto J. et al. FIO2 in an Adult Model Simulating High-Flow Nasal Cannula Therapy. Respir Care 2016; 62: 193-198
  • 31 Wagstaff TAJ, Soni N. Performance of six types of oxygen delivery devices at varying respiratory rates. Anaesthesia 2007; 62: 492-503
  • 32 Lenglet H, Sztrymf B, Leroy C. et al. Humidified high flow nasal oxygen during respiratory failure in the emergency department: feasibility and efficacy. Respir Care 2012; 57: 1873-1878
  • 33 Sztrymf B, Messika J, Mayot T. et al. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care 2012; 27: 324.e9-e13
  • 34 Corley A, Caruana LR, Barnett AG. et al. Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth 2011; 107: 998-1004
  • 35 Parke RL, McGuinness SP, Eccleston ML. A preliminary randomized controlled trial to assess effectiveness of nasal high-flow oxygen in intensive care patients. Respir Care 2011; 56: 265-270
  • 36 Parke R, McGuinness S, Dixon R. et al. Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients. Br J Anaesth 2013; 111: 925-931
  • 37 Corley A, Bull T, Spooner AJ. et al. Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI ≥ 30: a randomised controlled trial. Intensive Care Med 2015; 41: 887-894
  • 38 Riera J, Pérez P, Cortés J. et al. Effect of high-flow nasal cannula and body position on end-expiratory lung volume: a cohort study using electrical impedance tomography. Respir Care 2013; 58: 589-596
  • 39 Szkulmowski Z, Belkhouja K, Le Q-H. et al. Bilevel positive airway pressure ventilation: factors influencing carbon dioxide rebreathing. Intensive Care Med 2010; 36: 688-691
  • 40 Schettino GPP, Chatmongkolchart S, Hess DR. et al. Position of exhalation port and mask design affect CO2 rebreathing during noninvasive positive pressure ventilation*. Crit Care Med 2003; 31: 2178-2182
  • 41 Ferguson GT, Gilmartin M. CO2 rebreathing during BiPAP ventilatory assistance. Am J Respir Crit Care Med 1995; 151: 1126-1135
  • 42 Racca F, Appendini L, Gregoretti C. et al. Helmet ventilation and carbon dioxide rebreathing: effects of adding a leak at the helmet ports. Intensive Care Med 2008; 34: 1461-1468
  • 43 Taccone P, Hess D, Caironi P. et al. Continuous positive airway pressure delivered with a “helmet”: Effects on carbon dioxide rebreathing*. Crit Care Med 2004; 32: 2090-2096
  • 44 Biselli PJC, Kirkness JP, Grote L. et al. Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study. J Appl Physiol 2017; 122: 82-88
  • 45 Zhan Q, Sun B, Liang L. et al. Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med 2012; 40: 455-460
  • 46 Ferguson ND, Fan E, Camporota L. et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 2012; 38: 1573-1582
  • 47 Jolliet P, Abajo B, Pasquina P. et al. Non-invasive pressure support ventilation in severe community-acquired pneumonia. Intensive Care Med 2001; 27: 812-821
  • 48 Ferrer M, Esquinas A, Leon M. et al. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med 2003; 168: 1438-1444
  • 49 Brochard L, Lefebvre J-C, Cordioli RL. et al. Noninvasive ventilation for patients with hypoxemic acute respiratory failure. Semin Respir Crit Care Med 2014; 35: 492-500
  • 50 Keenan SP, Sinuff T, Burns KEA. et al. Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ 2011; 183: E195-E214
  • 51 Mascheroni D, Kolobow T, Fumagalli R. et al. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med 1988; 15: 8-14
  • 52 Bellani G, Laffey JG, Pham T. et al. Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study. Am J Respir Crit Care Med 2017; 195: 67-77
  • 53 Antonelli M, Conti G, Moro ML. et al. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 2001; 27: 1718-1728
  • 54 Rochwerg B, Granton D, Wang DX. et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019; 45: 563-572
  • 55 Frat J-P, Thille AW, Mercat A. et al. Supplementary Appendix: High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372: 2185-2196
  • 56 Rittayamai N, Tscheikuna J, Rujiwit P. High-flow nasal cannula versus conventional oxygen therapy after endotracheal extubation: a randomized crossover physiologic study. Respir Care 2014; 59: 485-490
  • 57 Lin S-M, Liu K-X, Lin Z-H. et al. Does high-flow nasal cannula oxygen improve outcome in acute hypoxemic respiratory failure? A systematic review and meta-analysis. Respir Med 2017; 131: 58-64
  • 58 Maitra S, Som A, Bhattacharjee S. et al. Comparison of high-flow nasal oxygen therapy with conventional oxygen therapy and noninvasive ventilation in adult patients with acute hypoxemic respiratory failure: A meta-analysis and systematic review. J Crit Care 2016; 35: 138-144
  • 59 Leeies M, Flynn E, Turgeon AF. et al. High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis. Syst Rev 2017; 6: 202-210
  • 60 Roca O, Caralt B, Messika J. et al. An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy. Am J Respir Crit Care Med 2019; 199: 1368-1376
  • 61 Antonelli M, Conti G, Bufi M. et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 2000; 283: 235-241
  • 62 Elliott MW, Steven MH, Phillips GD. et al. Non-invasive mechanical ventilation for acute respiratory failure. BMJ 1990; 300: 358-360
  • 63 Adda M, Coquet I, Darmon M. et al. Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failure. Crit Care Med 2008; 36: 2766-2772
  • 64 Lemiale V, Mokart D, Resche-Rigon M. et al. Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure. JAMA 2015; 314: 1711-1719
  • 65 Frat J-P, Ragot S, Girault C. et al. Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial. Lancet Respir Med 2016; 4: 646-652
  • 66 Azoulay E, Pickkers P, Soares M. et al. Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study. Intensive Care Med 2017; 43: 1808-1819
  • 67 Azoulay E, Lemiale V, Mokart D. et al. Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial. JAMA 2018; 320: 2099-2107
  • 68 Hernández G, Vaquero C, Colinas L. et al. Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial. JAMA 2016; 316: 1565-1574
  • 69 Hernández G, Vaquero C, González P. et al. Supplementary Online content 2: Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial. JAMA 2016; 315: 1354-1361
  • 70 Stéphan F, Barrucand B, Petit P. et al. High-Flow Nasal Oxygen vs Noninvasive Positive Airway Pressure in Hypoxemic Patients After Cardiothoracic Surgery. JAMA 2015; 313: 2331-2339
  • 71 Bräunlich J, Wirtz H. Nasal high-flow in acute hypercapnic exacerbation of COPD. COPD 2018; 13: 3895-3897
  • 72 Bräunlich J, Beyer D, Mai D. et al. Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients. Respiration 2013; 85: 319-325
  • 73 Fraser JF, Spooner AJ, Dunster KR. et al. Nasal high flow oxygen therapy in patients with COPD reduces respiratory rate and tissue carbon dioxide while increasing tidal and end-expiratory lung volumes: a randomised crossover trial. Thorax 2016; 71: 759-761
  • 74 Bräunlich J, Dellweg D, Bastian A. et al. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD. COPD 2019; 14: 1411-1421
  • 75 Storgaard LH, Hockey H-U, Laursen BS. et al. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. COPD 2018; 13: 1195-1205
  • 76 Rea H, McAuley S, Jayaram L. et al. The clinical utility of long-term humidification therapy in chronic airway disease. Respir Med 2010; 104: 525-533
  • 77 Jaber S, Monnin M, Girard M. et al. Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial. Intensive Care Med 2016; 42: 1877-1887
  • 78 Frat J-P, Ricard J-D, Quenot J-P. et al. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial. Lancet Respir Med 2019; 7: 303-312