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Horm Metab Res 2019; 51(12): 765-769
DOI: 10.1055/a-1057-9469
Review

Thyroid Peroxidase Revisited – Whatʼs New?

Marlena Godlewska 
1   Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland
1   Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland
,
Damian Gawel 
2   Department of Immunohematology, Centre of Postgraduate Medical Education, Warsaw, Poland
2   Department of Immunohematology, Centre of Postgraduate Medical Education, Warsaw, Poland
,
Ashley M. Buckle 
2   Department of Immunohematology, Centre of Postgraduate Medical Education, Warsaw, Poland
1   Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland
,
J. Paul Banga
4   Kingʼs College London (Emeritus), London, UK
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Abstract

Thyroid peroxidase (TPO) is an enzyme that participates in thyroid hormone biosynthesis. TPO is also a major autoantigen in autoimmune thyroid diseases (AITD). In this review, we summarize the latest developments in the field of TPO research. We present the current understanding of immunodominant serologic determinants, frequency of TPO-specific autoantibodies in the population, as well as genetic and environmental factors contributing to their development. Moreover, we report recent progress in the clinical utilities of TPO autoantibody testing, including thyroid dysfunctions and extra-thyroidal disorders.

Key words

antibodies to thyroperoxidase - autoantibodies - autoimmunity - autoimmune thyroiditis - Gravesʼ disease - Hashimoto’s disease


Publication History

Received: 18 August 2019

Accepted: 05 November 2019

Article published online:
11 December 2019

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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