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Horm Metab Res 2019; 51(10): 639-648
DOI: 10.1055/a-0975-9207
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Relationship of Biological Markers of Body Fat Distribution and Corticosteroidogenic Enzyme Activities in Women with Polycystic Ovary Syndrome

Sebastião Freitas de Medeiros
1   Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Mato Grosso, Brazil
2   Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Matheus Antonio Souto de Medeiros
2   Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Bruna Barcelo Barbosa
2   Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
,
Márcia Marly Winck Yamamoto
2   Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil
› Author Affiliations
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Publication History

received 25 February 2019

accepted 11 July 2019

Publication Date:
02 October 2019 (online)

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Abstract

The aim of the study is to determine the impact of different anthropometric measurements of fat distribution on baseline sex-steroid concentrations and corticosteroidogenic enzyme activity in women with polycystic ovary syndrome compared to those with regular menstrual cycles. The current cross-sectional study included 106 normal cycling controls and 268 polycystic ovary syndrome patients. Patients with polycystic ovary syndrome, diagnosed by Rotterdam criteria, were divided in normoandrogenemic (n=91) and hyperandrogenemic (n=177). Anthropometric, biochemical, and hormone parameters were assessed and correlated with corticosteroidogenic enzyme activities in all three groups. Corticosteroidogenic enzyme activities were calculated using product-to-precursor ratios. Regarding sex-steroids individually, anthropometric parameters correlated with the concentrations of several androgens in polycystic ovary syndrome patients, most of them in patients with biochemical hyperandrogenism. The androgen precursors androstenedione, 17-hydroxyprogesterone, and dehydroepiandrosterone were less correlated with anthropometric parameters. The 17,20 lyase activity, in both Δ4 and Δ5 pathways, correlated with several anthropometric measurements in normo- and hyperandrogenemic polycystic ovary syndrome patients. The 17,20 lyase enzyme activity (Δ4 pathway) also correlated with conicity index, visceral adiposity index, and lipid accumulation product in the control group. 17-Hydroxylase activity positively correlated with waist-height ratio in both polycystic ovary syndrome groups. In contrast, 17-hydroxilase negatively correlated with the conicity index. Anthropometric markers of adiposity are associated with androgen levels and their precursors in blood. Body fat distribution correlates with the activities of some steroidogenic enzyme in both normo-and hyperandrogenemic polycystic ovary syndrome phenotypes. The molecular mechanisms involved in these associations are largely unclear and more investigations are required.

Key words

sex steroids - hyperandrogenism - steroidogenesis
 

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