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Drug Res (Stuttg) 2019; 69(11): 612-620
DOI: 10.1055/a-0958-1987
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

Fatemeh Ahmadi
1   Arak University of Medical Sciences, Arak, Iran
,
Saeed Hajihashemi
2   Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
,
Ali Rahbari
3   Department of Pathology, Arak University of Medical Sciences, Arak, Iran
,
Fatemeh Ghanbari
4   Department of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran
› Author Affiliations
Further Information

Publication History

received 13 April 2019

accepted 11 June 2019

Publication Date:
17 July 2019 (online)

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Abstract

Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats.

Methodology Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion.

Results NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation.

Conclusions The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.

Key words

nitroglycerine - renal ischemia-reperfusion injury - rat
 

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