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Exp Clin Endocrinol Diabetes 2021; 129(02): 112-117
DOI: 10.1055/a-0956-1919
Article

Adherence, Attitudes and Beliefs of Growth Hormone Deficient Patients – A Questionnaire-based Cohort Study

Felix Amereller
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Katharina Schilbach
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Jochen Schopohl
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
,
Sylvère Störmann
1   Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
› Author Affiliations Funding: JS has received lecture fees honoraria and grants from Novartis, Ipsen and Pfizer and grants from Chiasma and OPKO Health. He is also a consultant for Ipsen and Novartis. SS has received lecture fees honoraria and grants from Novartis, Ipsen and Pfizer.
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Abstract

Introduction GHD is a chronic and systemic disease requiring daily replacement of growth hormone (GHRT). Adherence and attitudes of adult GHD patients are not well known. We sought to assess patients’ knowledge of growth hormone deficiency (GHD) in association with treatment adherence and attitudes regarding available and upcoming treatment options.

Methods We performed a cross-sectional survey with a custom-made questionnaire at a single centre assessing data on demographics, knowledge of GHD, adherence and attitudes towards GHRT.

Results Of 106 eligible patients actively followed for GHD 70 returned the completed survey (return-rate 66%, 34 m/36 f; age 56±14 years). 46 patients were actively treated, but almost one third (n=24) refused GHRT. 12 patients had participated in clinical trials with LAGH (long-acting growth hormone). Overall, patients with GHRT showed good adherence. Patients refusing GHRT mostly feared side effects and/or had a lack of information/perceived effect. Disease knowledge and level of education were higher in treated than untreated patients (p=0.023/0.017). Only 36% of respondents would initiate treatment with LAGH. Patients with prior LAGH experience and patients with childhood-onset GHD were more likely to adopt LAGH (p=0.048/0.031).

Discussion Most often, misinformation causes patients to refuse GHRT. Possibly the understanding of their condition and consequences of non-treatment is limited. To improve adherence more focused educational and behavioural strategies may be needed. Willingness to begin a therapy with LAGH was lower than expected (36%). The reasons for reluctance against LAGH need to be elucidated.

Key words

treatment adherence - growth hormone deficiency - growth hormone therapy - recombinant growth hormone - health knowledge

Supplementary Material



Publication History

Received: 28 January 2019
Received: 29 May 2019

Accepted: 11 June 2019

Article published online:
02 July 2019

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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